A wireless multi-functional sensor badge for epidemiological studies

用于流行病学研究的无线多功能传感器徽章

• 批准号: 8520309
• 负责人: NONGJIAN TAO
• 金额: $ 35.28万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520309
• 关键词: Address; Air; Air Pollution; Algorithms; Biological Clocks; Breathing; Calibration; California; Carbon Monoxide; Cellular Phone; Certification; Chemicals; Child; Child health care; Chronic Disease; Collaborations; Communication; Computer software; Computers; Data; Data Collection; Data Display; Detection; Development; Devices; Disease; Elements; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Evaluation; Exposure to; Face; Formaldehyde; Frequencies; Furniture; Future; Gases; Genetic Predisposition to Disease; Goals; Health; Hour; Individual; Indoor Air Pollution; Industry; Location; Measurement; Measures; Methods; Monitor; National Children' s Study; Noise; Ozone; Particulate Matter; Performance; Physical activity; Pilot Projects; Population; Population Study; Process; Production; Quality Control; Research Personnel; Resources; Running; Safety; Sampling; Signal Transduction; Source; Study Subject; Study models; System; Technology; Testing; Time; Toxic Environmental Substances; Training; Validation; Variant; Weight; Wireless Technology; Wood material; Work; air sampling; cohort; computerized data processing; cost; cost effective; data acquisition; detector; disorder prevention; flexibility; graphical user interface; innovation; miniaturize; operation; sensor; tool; toxicant; transmission process; usability; user-friendly

DESCRIPTION (provided by applicant): Understanding environmental factors in many chronic diseases is a critical and necessary step towards the prevention of these diseases. Reaching the goal requires new tools that can accurately measure various environmental toxicants. Due to large variations in the individuals' genetic susceptibility and environmental exposure, an ideal tool must be wearable so that it can measure the toxicants in real time and within each individual's breathing zone. Several wearable devices have been developed to detect certain chemicals, or particulate matter, and they are expected to contribute to epidemiological studies. However, most epidemiological studies require a capability of assessing multiple analytes in real-time in order to accurately pin down the source of toxicants and efficiently determine if a particular analyte or a group of analytes are responsible for a disease. Pilot studies by others and us revealed that asking a subject, especially a child, to wear multiple different devices for an extended period of time faces several challenges. First, it will take substantial training resources for each child to correctly operate and for each researcher to efficiently maintain multiple devices. Second, the total weight, size and noise of multiple devices will be an unwelcome burden for a child. Third, even though each device could be inexpensive, the total cost of multiple devices can make large-scale population studies cost prohibitive. Finally, different devices have different sampling rates, internal clocks, and data collection frequencies and formats; correct interpretation and synchronization of data from these devices may be prohibitively complicated, especially when deploying them in large cohort settings. In the present project, an integrated multifunctional sensor will be developed using several innovations recently developed in the PIs' labs for real-time measurement of personal exposures. The sensor can simultaneously detect multiple important analytes, including nitric dioxide, ozone, carbon monoxide, formaldehyde, and particulate matter. These analytes are selected because they are important for studying health effects of both outdoor and indoor air pollution. In addition to the capability of detecting multiple analytes, the sensor has an embedded wireless chip that can communicate with cell phones and uses GPS and accelerometer to provide additional location and physical activity information. Finally the sensor will be miniaturized to a wearable badge size. The team will collaborate with industry to ensure quality and low cost production. The sensor development group and the epidemiologists will work together to test and validate the device.

描述（由申请人提供）：了解许多慢性疾病的环境因素是朝着预防这些疾病的关键而必要的一步。达到目标需要可以准确测量各种环境有毒物质的新工具。由于个体的遗传敏感性和环境暴露的差异很大，因此理想的工具必须可穿戴，以便它可以实时和每个人的呼吸区内测量毒物。已经开发了几种可穿戴设备来检测某些化学物质或颗粒物，并有望为流行病学研究做出贡献。但是，大多数流行病学研究都需要实时评估多个分析物，以便准确地固定有毒物质的来源，并有效地确定特定的分析物或一组分析物是否负责疾病。他人和美国的试点研究表明，要求一个受试者，尤其是一个孩子，在很长一段时间内佩戴多种不同的设备面临几个挑战。首先，将需要大量的培训资源才能使每个孩子正确操作，并使每个研究人员有效地维护多个设备。其次，多个设备的总重量，大小和噪音对于孩子来说将是不受欢迎的负担。第三，即使每种设备的价格便宜，多个设备的总成本也可能使大规模的人口研究成本高昂。最后，不同的设备具有不同的采样率，内部时钟以及数据收集频率和格式。从这些设备的数据正确解释和同步可能会非常复杂，尤其是在大型队列设置中部署它们时。 在本项目中，将使用最近在PIS实验室中开发的几项创新来开发一个集成的多功能传感器，以实时测量个人暴露。传感器可以同时检测多个重要分析物，包括一二氧化氮，臭氧，一氧化碳，甲醛和颗粒物。之所以选择这些分析物，是因为它们对于研究室外和室内空气污染的健康影响很重要。除了检测多个分析物的能力外，该传感器还具有嵌入式无线芯片，该芯片可以与手机通信，并使用GPS和加速度计提供其他位置和身体活动信息。最后，将传感器小型化至可穿戴徽章尺寸。该团队将与行业合作，以确保质量和低成本生产。传感器开发小组和流行病学家将共同努力测试和验证设备。