32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim Instrument

3T Magnetom Trio A Tim Instrument 的 32 通道头部线圈和硬件升级

• 批准号: 8640687
• 负责人: WILLIAM D ROONEY
• 金额: $ 11.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640687
• 关键词: Animals; Brain; Communities; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Head; Human; Image; Impaired cognition; Institution; Magnetic Resonance; Magnetic Resonance Imaging; Nerve Degeneration; Neurosciences; Neurosciences Research; Noise; Oregon; Phase; Physiology; Primates; Principal Investigator; RF coil; Research; Science; Signal Transduction; Spin Labels; Substance abuse problem; System; United States National Institutes of Health; design; flexibility; improved; instrument; neuro-oncology; neuroinflammation; operation; spectroscopic imaging

DESCRIPTION (provided by applicant): The OHSU Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU community. The Center now supports four high-end research-dedicated MRI instruments that include two whole-body 3 Tesla (T) Siemens TIM Trios, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.75T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). The subject of this application is to request funds for a 32-channel phased array receiver coil designed for human brain studies on our Marquam Hill 3T MRI instrument. This MRI instrument has been in operation since 2006 and was originally outfitted with a 12-channel head receiver coil. The 3T MRI instrument has provided support to more than 40 principal investigators with projects funded primarily through federal agencies. Neuroscience is particularly strong at OHSU and the institution consistently ranks within the top 1% nationally in terms of NIH support for neuroscience research. Approximately 70% of the research performed on the 3T involves brain studies and utilizes the 12-channel RF coil. This MRI system is heavily subscribed for studies in neuro-oncology, neuroinflammation, neurodegeneration, substance abuse, and cognitive impairment. This instrument is routinely used for technically demanding applications that probe physiology and function and includes dynamic contrast MRI, arterial spin labeling, diffusion tensor imaging, functional MRI, and spectroscopic imaging. The proposed upgrade to a 32-channel receiver coil and associated hardware with substantially benefit on-going studies by providing marked increases in signal to noise and greatly increased acquisition flexibility offered by improved parallel acquisition strategies.

描述（由申请人提供）： OHSU 高级成像研究中心 (AIRC) 成立于 2003 年，旨在为 OHSU 社区提供最先进的磁共振科学仪器和专家技术支持。中心现支持四台高端研究专用磁共振仪器，包括两台全身3特斯拉（T）西门子TIM Trios、一台大口径（90厘米）7T西门子Magnetom和一台31厘米口径11.75T布鲁克小动物仪器。其中三台仪器位于位于 Marquam Hill 的 OHSU 主校区，俯瞰波特兰市中心，其中一台 3T MRI 仪器位于俄勒冈国家灵长类动物研究中心 (ONPRC) 校园内的卫星 AIRC 设施。本申请的主题是为 32 通道相控阵接收器线圈申请资金，该线圈专为在我们的 Marquam Hill 3T MRI 仪器上进行人脑研究而设计。该 MRI 仪器自 2006 年以来一直在运行，最初配备了 12 通道头部接收器线圈。 3T MRI 仪器已为 40 多名主要研究人员提供了支持，其项目主要由联邦机构资助。 OHSU 的神经科学尤其强大，在 NIH 对神经科学研究的支持方面，该机构始终名列全国前 1%。在 3T 上进行的大约 70% 的研究涉及大脑研究并利用 12 通道射频线圈。该 MRI 系统广泛用于神经肿瘤学、神经炎症、神经退行性变、药物滥用和认知障碍的研究。该仪器通常用于探测生理学和功能的技术要求较高的应用，包括动态对比 MRI、动脉自旋标记、扩散张量成像、功能 MRI 和光谱成像。所提议的 32 通道接收器线圈和相关硬件的升级通过显着提高信噪比以及通过改进的并行采集策略大大提高采集灵活性，极大地有益于正在进行的研究。