A Bruker Console Upgrade for the OHSU Advanced Imaging Research Center 11.7T MRI

OHSU 高级成像研究中心 11.7T MRI 的布鲁克控制台升级

• 批准号: 10430872
• 负责人: WILLIAM D ROONEY
• 金额: $ 158万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430872
• 关键词: 16 year old; Animal Disease Models; Animals; Area; Clinical Research; Communities; Data; Development; Disease; Early Diagnosis; Early Intervention; Environment; Faculty; Funding; Health Sciences; Image; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Methods; Oregon; Performance; Plant Roots; Play; Prevention; Primates; Research; Research Personnel; Role; Scanning; Science; Speed; Universities; Work; data access; data acquisition; human disease; image reconstruction; improved; instrument; operation; prisma; temporal measurement

Project Summary/Abstract The Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU research community. The Center now supports four high-end research-dedicated MRI instruments that includes two whole-body 3 Tesla(T) Siemens Prisma scanners, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.7T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). Each of these instruments has substantial capability to generate large amounts of data, allows investigators to work seamlessly between small/large animal models of disease and clinical studies and, in doing so, advance our understanding of the root causes of human disease. Ultimately, we expect the magnetic resonance data generated by the OHSU community to play a pivotal role in the development of new methods of prevention, early diagnosis and intervention for many disease states. However, the image quality, temporal resolution, scanning environment, and maintenance concerns necessary to remain productive in this area requires that our 16 year old 11.7T small animal MRI instrument be upgraded. The subject of this application is to request funds for an upgrade of our current Bruker AVANCE II to a Bruker a Bruker AVANCE NEO console. Our current instrument has been in operation since 2006 and supports more than 20 investigators, many junior faculty with projects funded through federal agencies, and plans for a large number of new studies as we move forward. The proposed upgrade will provide much needed improvements in gradient performance, data acquisition speed, temporal stability, improved workflow, and post-processing capabilities (data access, image reconstruction, calculation) and reduced downtime; capabilities that will substantially benefit on-going and newly proposed studies.

项目摘要/摘要 建立了俄勒冈健康与科学大学（OHSU）高级成像研究中心（AIRC） 2003年，为获得磁共振的最新工具和专家技术支持提供访问 OHSU研究社区的科学。该中心现在支持四个高端研究专用MRI 包括两个全身3特斯拉（t）西门子Prisma扫描仪的仪器，一个大口径（90厘米）7T 西门子的磁极和31厘米的孔11.7T布鲁克小动物仪器。其中三个乐器是 位于Marquam Hill的主要OHSU校园，俯瞰波特兰市中心，其中之一 3T MRI仪器位于俄勒冈国家灵长类动物校园的卫星AIRC设施 研究中心（ONPRC）。这些仪器中的每一个都有很大的能力产生大量 数据，允许研究人员在疾病的小型/大动物模型和临床上无缝工作 研究并这样做，可以提高我们对人类疾病根本原因的理解。最终，我们 期望OHSU社区产生的磁共振数据在 开发许多疾病状态的新预防方法，早期诊断和干预方法。 但是，必要的图像质量，时间分辨率，扫描环境和维护问题 要在这一领域保持生产力，要求我们升级我们16岁的11.7吨小动物MRI仪器。 本申请的主题是要求将我们当前的布鲁克·阿瓦斯ii升级到布鲁克的升级a请求资金 Bruker Avance Neo Console。我们目前的工具自2006年以来一直在运行，并支持更多 比20名调查人员，许多初级教师，由联邦机构资助，并计划大型计划 随着我们的前进，新研究的数量。拟议的升级将提供急需的改进 在梯度性能，数据采集速度，时间稳定性，改进工作流程和后处理 功能（数据访问，图像重建，计算）和减少停机时间；将会的功能 实质上有益于正在进行的研究和新提出的研究。