MIT Center for Integrative Synthetic Biology

麻省理工学院综合合成生物学中心

基本信息

批准号：
8901199
负责人：
RON WEISS
金额：
$ 205.97万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-25 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8901199
关键词：
Address Antibiotic Resistance Antibiotics Area Autoimmune Process Bacteria Bacteriophages Behavior Biochemical Biochemical Pathway Biological Biology Biotechnology Breathing Cancerous Cells Chemicals Collaborations Communicable Diseases Communities DNA DNA biosynthesis Data Development Devices Diabetes Mellitus Differential Equation Discipline Disease Drug Targeting Electronics Engineering Equation Frequencies Future Gene Expression Profile Genes Genome engineering Health Homeostasis Human Insulin Intervention Islet Cell Knowledge Libraries Malignant Neoplasms Maps Methods Microbial Biofilms Molecular Nucleic Acids Population Proteins Pseudomonas aeruginosa RNA RNA Interference Registries Research Research Personnel Science Signal Transduction Specificity System Systems Analysis Systems Biology Techniques Therapeutic Therapeutic Uses Tissues Transcriptional Regulation Translating Virus Yeasts base biological systems biophysical model cancer cell computer framework computerized tools design frontier fundamental research human disease killings novel novel therapeutics pathogen promoter prototype simulation stem cell differentiation synthetic biology theories tool

项目摘要

The MIT Center for Integrative Synthetic Biology will create the therapeutics of the future by integrating systems biology and synthetic biology. Systems biology, synthetic biology, and fundamental research in health-related applications are three major disciplines that have thrived in the last decade. These fields have pushed the frontiers of biomedical science with the development of high-throughput platforms for generating and analyzing systems-level data, unprecedented abilities to engineer biological systems, and significant advances in our understanding of the molecular mechanisms underlying human disease. However, due to the diverse expertise required in each discipline, these efforts have been largely independent from each other. Therefore there is a significant opportunity for the integration of systems biology, synthetic biology, and health-related applications in a single research center. Our core group of researchers at MIT is poised to spearhead efforts to overcome these challenges with the MIT Center for Integrative Synthetic Biology. A key feature of the proposed Center is our focus on interdisciplinary and collaborative research into next-generation therapeutics. Our major disease-related targets revolve around Cancer, Diabetes, and Infectious Diseases. Together systems biology and synthetic biology will contribute to significant advances in health-related applications. By integrating top-down systems views of disease with bottom-up synthetic construction of novel treatments, this community will create new disease therapies with the ability to integrate multiple inputs and deliver specific interventions. Numerous synergies in synthetic biology, systems biology, and health-related applications will be generated by the MIT Center for Integrated Synthetic Biology which would be difficult to achieve via solely independent investigator-led research efforts.

MIT综合合成生物学中心将通过整合系统生物学和合成生物学来创造未来的疗法。与健康相关应用的系统生物学，合成生物学和基础研究是过去十年中繁荣发展的三个主要学科。这些领域通过开发高通量平台来推动生物医学科学的前沿，以生成和分析系统级别的数据，前所未有的能力来设计生物系统，并在我们对人类疾病潜在的分子机制的理解方面取得了重大进展。但是，由于每个学科所需的多种专业知识，这些努力在很大程度上彼此独立。因此，在单个研究中心将系统生物学，合成生物学和与健康相关的应用集成有很大的机会。我们在麻省理工学院的核心研究人员组成的核心研究人员有望通过MIT综合合成生物学中心来克服这些挑战，以克服这些挑战。拟议中心的一个关键特征是我们专注于对下一代治疗剂的跨学科和协作研究。我们与疾病相关的主要靶标围绕癌症，糖尿病和传染病。系统生物学和合成生物学共同有助于与健康相关的应用方面的重大进展。通过将自上而下的疾病系统视图与自下而上的新疗法合成结构相结合，该社区将创建新的疾病疗法，能够整合多个输入并提供特定的干预措施。 MIT综合生物学中心将产生合成生物学，系统生物学和与健康相关应用的许多协同作用，这将很难通过独立的独立研究者主导的研究工作来实现。