Research and Mentoring in the Clinical Epidemiology of Type 2 Diabetes

2 型糖尿病临床流行病学研究和指导

基本信息

批准号：
8945373
负责人：
Elizabeth Selvin
金额：
$ 13.18万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8945373
关键词：
Acute Acute Renal Failure with Renal Papillary Necrosis Address Age Ancillary Study Area Atherosclerosis Award Awareness Biological Biological Markers Blood Blood Glucose Self-Monitoring Blood Pressure Budgets Cardiac Cardiovascular Diseases Cardiovascular system Chronic Clinical Research Clinical Trials Design Clinical assessments Cognitive Collaborations Collection Communities Continuous Positive Airway Pressure Contracts Data Data Collection Diabetes Mellitus Doctor of Philosophy Dyslipidemias Early Intervention Elderly Ensure Equation Event Filtration Fructosamine Funding Future Galectin 3 Glucose Glycosylated hemoglobin A Goals Grant Heart Heart failure Heterogeneity Hyperglycemia Impaired cognition Impairment Incidence Inflammation Injury Intervention Kidney Kidney Diseases Knowledge Laboratories Liver Maryland Measurement Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Morbidity - disease rate NT-proBNP National Heart, Lung, and Blood Institute Neurocognitive Non-Insulin-Dependent Diabetes Mellitus Obstructive Sleep Apnea Outcome Participant Patients Persons Physical Function Prediabetes syndrome Prospective Studies Public Health Randomized Clinical Trials Recording of previous events Recruitment Activity Recurrence Renal function Research Research Methodology Research Personnel Risk Risk Factors Schedule Scientist Self Care Sleep Apnea Syndromes Stratification Subgroup Surveys Telephone Testing Time Training Translational Research United States National Institutes of Health Universities Urine Visit aged base blood glucose regulation burden of illness cardiovascular risk factor career clinical epidemiology comparative experience glycosylated serum albumin high risk improved insight liver function medical schools mortality myocardial damage next generation novel patient oriented prevent primary outcome prognostic value public health relevance response secondary outcome success therapy design treatment adherence

项目摘要

DESCRIPTION (provided by applicant): Type 2 diabetes is a major public health concern, particularly in older adults. There are major gaps in our knowledge about diabetes in the elderly. In older adults, there is controversy regarding the total burden of risk associated with diabetes, optimal treatment targets, and how best to reduce cardiovascular risk and prevent cognitive and physical impairment. Novel biomarkers of diabetes and cardiovascular disease reflect the summation of acute and chronic morbidity and may have utility for informing treatment decisions but they have not been rigorously evaluated in older adults in the community. To address these issues we need junior patient-oriented investigators who will need rigorous training and mentorship in the areas of clinical epidemiology, translational research methods, and the conduct of large clinical studies including randomized clinical trials. The candidate, Elizabeth Selvin, PhD, MPH, has devoted her career to the study of the clinical epidemiology of type 2diabetes and the mentorship of trainees in this field. This midcareer award will protect the time of the candidate for research and mentoring. The goals of the project are to characterize diabetes incidence and progression in older adults, evaluate diabetes awareness and barriers to self-care and treatment adherence, and to examine the prognostic value of novel biomarkers for risk stratification. We will also evaluate the comparative response of traditional and novel cardiometabolic biomarkers to a glucose-lowering intervention in a randomized clinical trial of persons with type 2 diabetes. These projects will provide a rich substrate for training and new research opportunities for mentees. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With support from this K24, Dr. Selvin will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

描述（由申请人提供）：2 型糖尿病是一个主要的公共卫生问题，特别是对于老年人而言，我们对老年人糖尿病的了解存在重大差距，关于与老年人相关的总风险负担存在争议。糖尿病、治疗最佳目标以及如何最好地降低心血管风险并预防认知和身体损害糖尿病和心血管疾病的新型生物标志物反映了急性和慢性发病率的总和，可能有助于指导治疗决策，但尚未经过严格评估。在老年人中为了解决这些问题，我们需要以患者为中心的初级研究人员，他们需要在临床流行病学、转化研究方法以及开展包括随机临床试验在内的大型临床研究方面接受严格的培训和指导。博士、公共卫生硕士，她的职业生涯致力于 2 型糖尿病的临床流行病学研究和该领域学员的指导。该职业生涯中期奖项将保护候选人的研究和指导时间。该项目的目标是。为了描述老年人糖尿病的发病率和进展情况，评估糖尿病患者自我保健和治疗依从性的意识和障碍，并检查新型生物标志物对风险分层的预后价值，我们还将评估传统和新型心脏代谢生物标志物对糖尿病的比较反应。对 2 型糖尿病患者进行的一项随机临床试验的降血糖干预措施将为学员提供丰富的培训基础和新的研究机会。塞尔文博士在该领域和指导青少年方面拥有良好的成功记录。科学家.在支持下从这次 K24 开始，塞尔文博士将能够扩大她的指导活动，加强她的研究组合，并招募和培训该领域的下一代领导者。