Clinical relevance of glucose patterns in older adults

老年人血糖模式的临床相关性

基本信息

批准号：
10361563
负责人：
Elizabeth Selvin
金额：
$ 65.9万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10361563
关键词：
Adult Age Atherosclerosis Risk in Communities Biological Markers Cardiac Cardiovascular Diseases Clinical Data Development Diabetes Mellitus Diagnosis Disease Elderly Frequencies Fructosamine Funding Future Glucose Glycosylated hemoglobin A Goals Grant Guidelines Health Health Status Homeostasis Hyperglycemia Hypoglycemia Impaired cognition Investigation Kidney Laboratories Lead Manuscripts Measurement Measures Methods Motivation Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Pattern Peripheral Nervous System Diseases Persons Physical Function Physiological Population Prediabetes syndrome Quality of life Recommendation Risk Risk Factors Serum Technology Time Uncertainty Variant Visit Vulnerable Populations Work blood glucose regulation clinical practice clinically relevant cognitive function cohort evidence base follow-up frailty glucose monitor glycosylated serum albumin health related quality of life human old age (65+)mortality non-diabetic novel prognostic prospective response success virtual

项目摘要

Abstract Disordered glucose homeostasis and glucose instability are common in older adults. Age is one of the most important risk factors for the development of type 2 diabetes and there is growing evidence that glycemic variability contributes to risk of complications, independent of average glucose or HbA1c. In older adults with diabetes, there is controversy regarding appropriate treatment targets and hypoglycemia is a major concern. Continuous glucose monitoring (CGM) is the recommended approach to the assessment of hypoglycemia and glycemic variability, but this technology has rarely been used in older adults. Very old adults (age 80 years or older) are a particularly vulnerable population but have rarely been included in prior studies. Our overarching objective is to characterize glucose patterns in older adults (>80 years) using state-of-the-art CGM technology. We will characterize “normal” glucose patterns and evaluate the frequency of unrecognized glycemic excursions in adults with and without diabetes (including persons with prediabetes). We will relate glucose patterns including glucose excursions (hypo- and hyperglycemia) to current health status and clinical outcomes during 4 years of follow-up. These results will provide information on the clinical relevance of glucose patterns in an older adult population and generate evidence-based guidance regarding the use and interpretation of CGM in this population.

抽象的血糖稳态紊乱和血糖不稳定在老年人中很常见，年龄是最常见的原因之一。 2 型糖尿病的重要危险因素，越来越多的证据表明血糖在老年人中，变异性会增加并发症的风险，与平均血糖或 HbA1c 无关。糖尿病，关于适当的治疗目标存在争议，低血糖是一个主要问题。连续血糖监测（CGM）是评估低血糖和低血糖的推荐方法血糖变异性，但这项技术很少用于老年人（80 岁或以上）。老年人）是特别脆弱的人群，但很少被纳入先前的研究中。目标是使用最先进的 CGM 技术来表征老年人（> 80 岁）的血糖模式。我们将描述“正常”血糖模式的特征并评估未识别血糖的频率患有和不患有糖尿病的成年人（包括患有糖尿病前期的人）的旅行我们将与血糖相关。模式，包括血糖波动（低血糖和高血糖）到当前健康状况和临床结果在 4 年的随访期间，这些结果将提供有关血糖模式的临床相关性的信息。并就老年人群的使用和解释提供基于证据的指导此人群中的连续血糖监测 (CGM)。