Research and Mentoring in the Clinical Epidemiology of Cardiovascular Disease and Type 2 Diabetes

心血管疾病和 2 型糖尿病的临床流行病学研究和指导

基本信息

批准号：
9977473
负责人：
Elizabeth Selvin
金额：
$ 12.24万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9977473
关键词：
Acute Address Appointment Area Award Biological Markers Biometry Budgets Cardiac Cardiology Cardiovascular Diseases Cardiovascular system Cessation of life Chronic Clinical Clinical Chemistry Clinical Research Cognitive Diabetes Mellitus Discipline of Nursing Doctor of Philosophy Educational Status Elderly Endocrinology Environment Epidemiologic Methods Epidemiology Faculty Funding Genomics Goals Grant Health Health Promotion Hyperglycemia Imaging technology Impairment Internal Medicine Journals K-Series Research Career Programs Knowledge Manuscripts Master&apos s Degree Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Monitor Morbidity - disease rate Neurology Non-Insulin-Dependent Diabetes Mellitus Persons Pilot Projects Prediabetes syndrome Prevention Prevention Research Proteomics Public Health Public Health Schools Publications Publishing Randomized Clinical Trials Research Research Methodology Research Personnel Research Project Grants Risk Role School Nursing Scientific Advances and Accomplishments Scientist Serum Talents Time Training Training Activity Translational Research United States National Institutes of Health cardiometabolism cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular risk factor career career development clinical decision-making clinical epidemiology collaborative environment design disorder prevention epidemiology study evidence base faculty mentor improved medical schools member mortality multidisciplinary next generation novel optimal treatments patient oriented patient oriented research prevent programs recruit screening success tool

项目摘要

Cardiovascular disease and type 2 diabetes are major public health concerns, particularly in older adults. There are major gaps in our knowledge about diabetes and how to prevent its associated microvascular and cardiovascular complications. In older adults, there is controversy regarding the total burden of risk associated with diabetes and prediabetes, optimal treatment targets, and how best to reduce cardiovascular risk and prevent cognitive and physical impairment. Novel cardiac biomarkers reflect the summation of acute and chronic morbidity and may have utility for informing treatment decisions in diabetes and other cardiometabolic conditions, but they have not been rigorously evaluated. To address these issues, we need junior patient- oriented investigators who will need rigorous training and mentorship in the areas of clinical epidemiology, translational research methods, and the conduct of large clinical studies. The candidate, Elizabeth Selvin, PhD, MPH, has devoted her career to the study of the clinical epidemiology of type 2 diabetes and cardiovascular disease and the mentorship of trainees in this field. The continuation of this K24 award will protect the time of the candidate for research and mentoring. The goals during this award are to recruit a team of diverse, multi- disciplinary junior investigators who will receive mentorship in the clinical epidemiology of cardiovascular disease and diabetes; to promote formal training in epidemiology and clinical research methods for beginning clinician investigators; and to mentor trainees to address significant research questions in the field and help launch their independent research careers. Dr. Selvin's large research portfolio (including three R01 grants) will provide a rich substrate for training and new research opportunities for mentees. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With continued support from this K24, she will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

心血管疾病和 2 型糖尿病是主要的公共卫生问题，尤其是老年人。我们对糖尿病以及如何预防其相关的微血管和糖尿病的了解存在重大差距。心血管并发症。对于老年人来说，相关风险的总负担存在争议。糖尿病和糖尿病前期的最佳治疗目标，以及如何最好地降低心血管风险和预防认知和身体障碍。新型心脏生物标志物反映了急性和心脏疾病的总和慢性发病率，可能有助于糖尿病和其他心脏代谢疾病的治疗决策条件，但尚未经过严格评估。为了解决这些问题，我们需要初级患者—— 需要临床流行病学领域严格培训和指导的定向研究人员，转化研究方法，以及进行大型临床研究。候选人伊丽莎白·塞尔文博士， MPH，致力于2型糖尿病和心血管疾病的临床流行病学研究疾病和该领域受训人员的指导。这个K24奖项的延续将保护我们的时间研究和指导的候选人。该奖项的目标是招募一支多元化、多元化的团队将接受心血管临床流行病学指导的学科初级研究者疾病和糖尿病；促进流行病学和临床研究方法的正规培训临床医生调查员；并指导学员解决该领域的重大研究问题并帮助开始他们的独立研究生涯。 Selvin 博士的大量研究成果（包括三项 R01 资助）将为学员提供丰富的培训基础和新的研究机会。塞尔文博士有很强的在该领域和指导初级科学家方面拥有成功的记录。在K24的持续支持下，她将能够扩大她的指导活动，加强她的研究组合，并招募和培训下一个该领域的一代领袖。