Role of BDNF on Risk Behavior Decision Making

BDNF 在风险行为决策中的作用

• 批准号: 8698651
• 负责人: Maria-Jose Miguez
• 金额: $ 43.49万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8698651
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Risk Behavior; Adult; Affect; Affective; African American; Age; Alcohols; Animals; Applications Grants; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain-Derived Neurotrophic Factor; Childhood; Clinical; Cognitive; Coitus; Competence; Complex; County; Data; Decision Making; Development; Dimensions; Discrimination; Disease; Distress; Down-Regulation; Drug usage; Ensure; Environment; Environmental Risk Factor; Epidemic; Evaluation; Family; Florida; Goals; HIV; HIV risk; Health; Heavy Drinking; Hispanic-serving Institution; Hispanics; Human; Impulsivity; Individual; International; Intervention; Investigation; Knowledge; Life; Life Experience; Link; Longitudinal Studies; Measurement; Mediating; Mental Depression; Minority; Modeling; Moods; Nature; Neurobiology; Neuromodulator; New York; Outcome; Participant; Personal Satisfaction; Plasma; Population; Poverty; Prevalence; Primates; Problem behavior; Process; Questionnaires; Recombinants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Role; Seroprevalences; Site; Solutions; Staging; Stress; Subgroup; Surveys; Testing; Therapeutic; Time; United States; Universities; Withdrawal; Work; Youth; addiction; adolescent brain development; base; behavioral study; biological adaptation to stress; cofactor; cognitive function; cognitive process; computerized; condoms; decision-making capacity; design; ethnic minority population; executive function; follow-up; heuristics; high risk; information gathering; inner city; innovation; interdisciplinary collaboration; neglect; neurochemistry; neuromechanism; neuropsychological; neurotrophic factor; novel; pressure; psychologic; psychosocial; resilience; sex risk; social; social anxiety; social separation; statistics; success; theories; therapeutic target; therapy design; transmission process; twelfth grade

This proposed R01 is a 5-year longitudinal bio-psycho-social integrative study of inner-city Hispanic adolescents, designed as a proof-of-concept of the neglected role of the neuromodulator BDNF (brain derived neurotrophic factor) in decision making (DM) and HIV-Transmission Risk Behaviors (TRBs). In addition to promising preliminary research findings, the impetus for this proposal is Hispanic seroprevalence in Florida, which is nearly twice the national rate. Long a primary U.S. epicenter, the latest available data shows that Florida¿s HIV epidemic is unexpectedly grim, ranking 3rd in cumulative AIDS cases, 2nd in cumulative pediatric cases. Because of heightened risk-taking, adolescents are considered among the high-risk HIV subgroups. Moreover, among 34 states in 2007, Florida ranked 2nd (behind New York) in the number of adolescents (13 to 19 years) living with HIV/AIDS, with the highest concentration in S. Florida¿s Miami-Dade and Broward counties, the sites of this proposal. This highlights the urgency for enhancing current understanding of risk and vulnerability factors in these minority subpopulations, particularly neurobiological factors that have been largely neglected in prior work and rarely examined in ethnic minority adolescents. The proposed study tests a theory-grounded- decision making model among Hispanic adolescents, which emphasizes the neuromodulator BDNF, extending its evaluation from alcohol/drug use to sexual risk behavior, in a framework that hypothesizes that disturbances are likely to: a) alter cognitive process; b) link to complex behaviors such as decision making and adaptation; and c) be highly relevant to problems in maintaining psychological well-being, particularly under stressful situations. The study also aims to explore the interaction of family/environment with adolescents¿ neurobiochemical factors in affecting HIV-TRBs given its pivotal role during adolescent brain development, and DM. With the support of local Health Departments, we propose to recruit 500 Hispanic adolescents (13-16 years), with follow-up over two years (3 time points) to examine the inter-relationships of biological and neuropsychological factors, and life experiences on HIV-TRBs, and to capture transition to later developmental stages. The proposed project is a transdisciplinary collaboration that will contribute new bio-behavioral knowledge to target neural mechanisms for which clinical solutions already exist. Treatments are currently available that may ameliorate suboptimal neurochemical levels (e.g., recombinant BDNF). In addition, because BDNF is implicated in both affective and cognitive dimensions of decision making, the proposed study also offers an innovative strategy for the highly sought-ever goal of integrating neurobiology into behavioral interventions among these susceptible populations.

该提出的R01是一项5年的纵向生物心理社会社会综合研究 青少年被设计为神经调节剂BDNF的忽视作用的概念证明（脑 在决策（DM）和HIV传播风险行为（TRB）中衍生的神经营养因素）。在 除了有希望的初步研究结果，该提议的动力是西班牙裔 佛罗里达州的血清价值几乎是全国率的两倍。长期是美国主要的中心，最新的 可用的数据表明，佛罗里达州的艾滋病毒流行意外严峻，在累积艾滋病中排名第三 病例，累积小儿病例。由于冒险的增加，因此考虑了青少年 在高风险的HIV亚组中。此外，在2007年的34个州中，佛罗里达州排名第二（落后于新） 约克）在艾滋病毒/艾滋病的青少年数量（13至19岁）中 S.佛罗里达州迈阿密戴德和布劳沃德县，该提议的地点。这突出了 在这些少数群体亚群中增强对风险和脆弱性因素的当前理解， 特别是在先前工作中很大程度上忽略的神经生物学因素，很少在 少数民族青少年。拟议的研究测试了理论基础的决策模型 强调神经调节剂BDNF的西班牙裔青少年，从 在假设灾难可能会有的框架内，酒精/毒品用于性风险行为： a）改变认知过程； b）与诸如决策和适应之类的复杂行为的联系； c）是 与维持心理健康方面的问题高度相关，尤其是在压力很大的情况下。 该研究还旨在探索家庭/环境与青少年的相互作用。神经化学 鉴于其在青少年大脑发育中的关键作用和DM，影响HIV-TRB的因素。与 我们的支持当地卫生部门，我们建议招募500名西班牙裔青少年（13 - 16年），并与 在两年（3个时间点）的后续行动，以检查生物学和 神经心理学因素和HIV-TRB上的生活经历，并捕获过渡到以后 发展阶段。拟议的项目是跨学科的合作，将为新的贡献 生物行为知识旨在针对已经存在临床解决方案的神经力学。 目前可用的治疗可改善次优神经化学水平（例如，重组 bdnf）。此外，由于BDNF与决策的情感和认知维度有关 拟议的研究还为有史以来的融合目标提供了创新的策略 这些易感人群中的神经生物学对行为干预。