Role of BDNF on Risk Behavior Decision Making

BDNF 在风险行为决策中的作用

• 批准号: 8698651
• 负责人: Maria-Jose Miguez
• 金额: $ 43.49万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8698651
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Risk Behavior; Adult; Affect; Affective; African American; Age; Alcohols; Animals; Applications Grants; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain-Derived Neurotrophic Factor; Childhood; Clinical; Cognitive; Coitus; Competence; Complex; County; Data; Decision Making; Development; Dimensions; Discrimination; Disease; Distress; Down-Regulation; Drug usage; Ensure; Environment; Environmental Risk Factor; Epidemic; Evaluation; Family; Florida; Goals; HIV; HIV risk; Health; Heavy Drinking; Hispanic-serving Institution; Hispanics; Human; Impulsivity; Individual; International; Intervention; Investigation; Knowledge; Life; Life Experience; Link; Longitudinal Studies; Measurement; Mediating; Mental Depression; Minority; Modeling; Moods; Nature; Neurobiology; Neuromodulator; New York; Outcome; Participant; Personal Satisfaction; Plasma; Population; Poverty; Prevalence; Primates; Problem behavior; Process; Questionnaires; Recombinants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Role; Seroprevalences; Site; Solutions; Staging; Stress; Subgroup; Surveys; Testing; Therapeutic; Time; United States; Universities; Withdrawal; Work; Youth; addiction; adolescent brain development; base; behavioral study; biological adaptation to stress; cofactor; cognitive function; cognitive process; computerized; condoms; decision-making capacity; design; ethnic minority population; executive function; follow-up; heuristics; high risk; information gathering; inner city; innovation; interdisciplinary collaboration; neglect; neurochemistry; neuromechanism; neuropsychological; neurotrophic factor; novel; pressure; psychologic; psychosocial; resilience; sex risk; social; social anxiety; social separation; statistics; success; theories; therapeutic target; therapy design; transmission process; twelfth grade

This proposed R01 is a 5-year longitudinal bio-psycho-social integrative study of inner-city Hispanic adolescents, designed as a proof-of-concept of the neglected role of the neuromodulator BDNF (brain derived neurotrophic factor) in decision making (DM) and HIV-Transmission Risk Behaviors (TRBs). In addition to promising preliminary research findings, the impetus for this proposal is Hispanic seroprevalence in Florida, which is nearly twice the national rate. Long a primary U.S. epicenter, the latest available data shows that Florida¿s HIV epidemic is unexpectedly grim, ranking 3rd in cumulative AIDS cases, 2nd in cumulative pediatric cases. Because of heightened risk-taking, adolescents are considered among the high-risk HIV subgroups. Moreover, among 34 states in 2007, Florida ranked 2nd (behind New York) in the number of adolescents (13 to 19 years) living with HIV/AIDS, with the highest concentration in S. Florida¿s Miami-Dade and Broward counties, the sites of this proposal. This highlights the urgency for enhancing current understanding of risk and vulnerability factors in these minority subpopulations, particularly neurobiological factors that have been largely neglected in prior work and rarely examined in ethnic minority adolescents. The proposed study tests a theory-grounded- decision making model among Hispanic adolescents, which emphasizes the neuromodulator BDNF, extending its evaluation from alcohol/drug use to sexual risk behavior, in a framework that hypothesizes that disturbances are likely to: a) alter cognitive process; b) link to complex behaviors such as decision making and adaptation; and c) be highly relevant to problems in maintaining psychological well-being, particularly under stressful situations. The study also aims to explore the interaction of family/environment with adolescents¿ neurobiochemical factors in affecting HIV-TRBs given its pivotal role during adolescent brain development, and DM. With the support of local Health Departments, we propose to recruit 500 Hispanic adolescents (13-16 years), with follow-up over two years (3 time points) to examine the inter-relationships of biological and neuropsychological factors, and life experiences on HIV-TRBs, and to capture transition to later developmental stages. The proposed project is a transdisciplinary collaboration that will contribute new bio-behavioral knowledge to target neural mechanisms for which clinical solutions already exist. Treatments are currently available that may ameliorate suboptimal neurochemical levels (e.g., recombinant BDNF). In addition, because BDNF is implicated in both affective and cognitive dimensions of decision making, the proposed study also offers an innovative strategy for the highly sought-ever goal of integrating neurobiology into behavioral interventions among these susceptible populations.

拟议的 R01 是一项针对市中心西班牙裔的为期 5 年的纵向生物心理社会综合研究 青少年，旨在证明神经调节剂 BDNF（大脑）被忽视的作用 衍生神经营养因子）在决策（DM）和艾滋病毒传播风险行为（TRB）中的作用。 除了有希望的初步研究结果外，该提案的推动力是西班牙裔 佛罗里达州的血清流行率几乎是美国主要疫情中心全国的两倍。 现有数据显示佛罗里达州HIV疫情出人意料的严峻，累计艾​​滋病排名第3 病例数，在累计儿科病例中排名第二，由于饮食冒险，青少年被考虑在内。 此外，在 2007 年 34 个州中，佛罗里达州排名第二（位于新州之后）。 约克）感染艾滋病毒/艾滋病的青少年（13 至 19 岁）人数最多，集中在 南佛罗里达州¿迈阿密戴德县和布劳沃德县是该提案的地点，这凸显了该提案的紧迫性。 加强目前对这些少数群体的风险和脆弱性因素的了解， 特别是神经生物学因素，这些因素在以前的工作中很大程度上被忽视了，并且很少在研究中得到研究。 拟议的研究测试了少数民族青少年的基于理论的决策模型。 西班牙裔青少年，强调神经调节剂 BDNF，将其评估延伸至 酗酒/吸毒对性危险行为的影响，在一个框架内，英雄们可能会： a) 改变认知过程；b) 与决策和适应等复杂行为相关； 与维持心理健康的问题高度相关，特别是在压力情况下。 该研究还旨在探讨家庭/环境与青少年的相互作用。神经生物化学 鉴于 HIV-TRB 在青少年大脑发育和 DM 中的关键作用，影响 HIV-TRB 的因素。 在当地卫生部门的支持下，我们建议招募 500 名西班牙裔青少年（13-16 岁）， 两年（3个时间点）的随访，以检查生物和疾病之间的相互关系 HIV-TRB 的神经心理因素和生活经历，并捕捉到以后的过渡 拟议的项目是一个跨学科的合作，将贡献新的成果。 针对已经存在临床解决方案的神经机制的生物行为知识。 目前可用的治疗方法可以改善次优的神经化学水平（例如重组 此外，BDNF 还与决策的情感和认知维度有关。 使得，拟议的研究还为高度追求的一体化目标提供了创新策略 神经生物学对这些易感人群的行为干预。