Descriptive Studies and Record Linkage

描述性研究和记录链接

基本信息

批准号：
8175392
负责人：
William Anderson
金额：
$ 69.11万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8175392
关键词：
AIDS-Related Burkitt&apos s Lymphoma AIDS/HIV problem Accounting Adenoid Cystic Carcinoma Adult African Age Age-Years Aging-Related Process American Anatomic Sites Area Asians Atlas of Cancer Mortality in the United States B-Cell NonHodgkins Lymphoma Brain Part Breast Burkitt Lymphoma Cancer Etiology Cancer Surveillance Research Carcinoma Caring Catchment Area Cell Aging Cellular Phone Characteristics Childhood Clinical Colon Carcinoma Colorectal Cancer Complement Computer software Contralateral Cutaneous Cutaneous Melanoma Data Data Analyses Data Linkages Databases Development Diagnosis Distal Division of Cancer Epidemiology and Genetics Epidemiology Epithelial ovarian cancer Ethnic group Exposure to Failure Family Female Formalin Functional disorder Funding Gender Gene Expression General Population Growth and Development function Hawaii Histopathology Hodgkin Disease Human Biology Incidence Inflammatory Institutes International Iowa Laboratories Link Maintenance Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of cecum Malignant neoplasm of cerebellum Malignant neoplasm of male breast Malignant neoplasm of testis Maps Measures Medical Medical Surveillance Methods Methylation Military Personnel Mismatch Repair Modeling Molecular Nonseminomatous Northern Europe Occupational Exposure Paraffin Embedding Parietal Lobe Pathologic Pathway interactions Pattern Play Population Proportional Hazards Models Proteins Publishing Race Radiation Radiation therapy Rare Diseases Rectal Cancer Registries Relative (related person)Reporting Research Research Personnel Residual state Risk Role Rosa SEER Program Screening procedure Seminoma Series Site Skin Cancer Specimen Stratification Subgroup Sun Exposure Survivors TP53 gene Testing Time Tissue Microarray Tissues Toxin Ultraviolet Rays United States Update Variant Woman age effect age group aged body system breast cancer diagnosis cancer epidemiology cancer risk cancer type carcinogenesis cohort comparative epidemiologic data experience frontal lobe geographic difference hazard high risk lifestyle factors male malignant breast neoplasm malignant stomach neoplasm meetings melanoma molecular marker mortality multidisciplinary programs racial and ethnic radiofrequency repaired repository sex surveillance data telomere trend tumor tumor registry

AIDS-Related Burkitt&apos s Lymphoma AIDS/HIV problem Accounting Adenoid Cystic Carcinoma Adult African Age Age-Years Aging-Related Process American Anatomic Sites Area Asians Atlas of Cancer Mortality in the United States B-Cell NonHodgkins Lymphoma Brain Part Breast Burkitt Lymphoma Cancer Etiology Cancer Surveillance Research Carcinoma Caring Catchment Area Cell Aging Cellular Phone Characteristics Childhood Clinical Colon Carcinoma Colorectal Cancer Complement Computer software Contralateral Cutaneous Cutaneous Melanoma Data Data Analyses Data Linkages Databases Development Diagnosis Distal Division of Cancer Epidemiology and Genetics Epidemiology Epithelial ovarian cancer Ethnic group Exposure to Failure Family Female Formalin Functional disorder Funding Gender Gene Expression General Population Growth and Development function Hawaii Histopathology Hodgkin Disease Human Biology Incidence Inflammatory Institutes International Iowa Laboratories Link Maintenance Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of cecum Malignant neoplasm of cerebellum Malignant neoplasm of male breast Malignant neoplasm of testis Maps Measures Medical Medical Surveillance Methods Methylation Military Personnel Mismatch Repair Modeling Molecular Nonseminomatous Northern Europe Occupational Exposure Paraffin Embedding Parietal Lobe Pathologic Pathway interactions Pattern Play Population Proportional Hazards Models Proteins Publishing Race Radiation Radiation therapy Rare Diseases Rectal Cancer Registries Relative (related person)Reporting Research Research Personnel Residual state Risk Role Rosa SEER Program Screening procedure Seminoma Series Site Skin Cancer Specimen Stratification Subgroup Sun Exposure Survivors TP53 gene Testing Time Tissue Microarray Tissues Toxin Ultraviolet Rays United States Update Variant Woman age effect age group aged body system breast cancer diagnosis cancer epidemiology cancer risk cancer type carcinogenesis cohort comparative epidemiologic data experience frontal lobe geographic difference hazard high risk lifestyle factors male malignant breast neoplasm malignant stomach neoplasm meetings melanoma molecular marker mortality multidisciplinary programs racial and ethnic radiofrequency repaired repository sex surveillance data telomere trend tumor tumor registry

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项目摘要

General descriptive studies (00350): Melanoma incidence rates are rising among young women, possibly due to increasing ultraviolet radiation to previously protected body sites. We examined melanoma incidence trends by age, gender, and body site. Descriptive methods were complemented with the age-period-cohort parameters, demonstrating that melanomas are rising preferentially on the trunk among young women. Emerging data suggest that cutaneous malignant melanomas (CMM) may arise through divergent cancer pathways that are linked to intermittent versus accumulated sun exposure. However, numerous questions remain regarding the timing and/or age of exposure. We examined the effect of aging on CMM incidence in data from SEER. Gender, histopathology, and anatomic site were age-specific effect modifiers for CMM. Other skin cancer analyses focused on the incidence patterns of the rare cutaneous appendageal carcinomas and cutaneous adenoid cystic carcinomas. Male breast cancer is a rare disease, accounting for less than 1% of all breast cancer diagnoses worldwide. A multidisciplinary international meeting on male breast cancer focused on highlighting differences and similarities between breast cancer in males and females. To further enhance our understanding of male breast cancer, the Breast International Group and North American Breast Cancer Group have joined efforts to develop an International Male Breast Cancer Program and to pool epidemiologic data, clinical information, and tumor specimens. In an analysis of invasive contralateral breast cancer among 5,631 inflammatory breast cancer (IBC) and 447,767 non-IBC first breast cancer cases who survived at least 2 months following diagnosis and were reported to 13 Surveillance, Epidemiology, and End Results (SEER) registries between January 1, 1973 and December 31, 2006, the general population the risk of developing a contralateral breast cancer was greater following a first IBC than non-IBC. International testicular cancer incidence rates remained highest in Northern Europe populations and lowest in Asian and African populations, and rose among most populations, with the trends for seminoma and nonseminoma generally similar. For the last 50 years, age-standardized incidence rates for noncardia gastric cancer have steadily declined in most populations. However, overall rates are summary measures that may obscure important age-specific trends. We analyzed SEER cancer incidence from 1977 through 2006 and found that the rate for noncardia gastric cancer declined among all race and age groups except for whites aged 25 to 39 years, for whom it increased. Our analysis of colorectal cancer incidence by gender, race/ethnic group, anatomic site, and age found that the male-to-female rate ratio rose from about one for cecal cancers to 1.8 for rectal cancers, increased with age most rapidly for distal colon cancers from <1.0 at ages <50 to 1.4-1.9 at older ages, and varied less by racial/ethnic group; these findings may partially reflect differences in screening experiences and access to medical care but also suggest that etiologic factors may be playing a role. There has been concern that the use of cellular telephones, which has grown explosively over the past two decades, may increase the risk of brain cancer. Our analysis of SEER brain cancer incidence found that during 1992-2006 the age-specific trends were downward or flat, except among females aged 20-29 years among whom the rates increased significantly. However, the increases were apparent only for frontal lobe cancers, and no increases were apparent for temporal or parietal lobe cancers, or cancers of the cerebellum, which involve the parts of the brain that would be more highly exposed to radiofrequency radiation from cellular phones. These data do not provide support to the view that cellular phone use causes brain cancer. Burkitt lymphoma (BL) is a unique B-cell non-Hodgkin lymphoma with 3 established clinical-epidemiological variants: endemic, sporadic and AIDS-related BL. Standard cross-sectional age-standardized and age specific incidence rates were stratified by sex and race and supplemented with ageperiodcohort models. Tri/bimodal incidence pattern was present in sensitivity analyses excluding registries with many HIV/AIDS cases and in period-specific, cohort-specific analyses. Young women treated with radiotherapy (RT) for Hodgkin lymphoma (HL) have a high risk of developing breast cancer (BC). To examine whether BC characteristics following HL differ from primary BC in the population remains uncertain. We identified 166 BC cases among 2,645 five-year survivors of HL in the SEER database that were diagnosed prior to age 35 years and treated with RT. Among 15-year survivors, greater increases in risk were seen for ER-negative/PR-negative versus ER-positive/PR-positive BC and higher risks emerged for high-grade versus low-grade tumors. We used thirty years of SEER incidence data to investigate the age-specific patterns for a series of cancers and found that the complicated underlying biology of human growth, development, and carcinogenesis was reflected in the highly disparate patterns across age groups. In childhood, the peak years of an organ systems increase in size correlate with peak years of cancer incidence. Conversely, in most adult-onset cancers, it is exposure to exogenous toxins, the failure of maintenance and repair, and finally, dysfunction(s) in the normal cellular aging process that likely play a role in the development of these malignancies. Special descriptive studies (10348): Ageperiodcohort (APC) analysis is used in cancer epidemiology to model trends in cancer rates. We developed methods for comparative APC analysis of two independent cause-specific hazard rates assuming that an APC model holds for each one. We constructed linear hypothesis tests to determine whether the two hazards are absolutely proportional or proportional after stratification by cohort, period, or age. When a given proportional hazards model appears adequate, we derived simple expressions for the relative hazards using identifiable APC parameters. To demonstrate the utility of these new methods, we analyzed cancer incidence rates in the United States in blacks versus whites for selected cancers. SEER special studies (00316): In 2001, the SEER program supplemented funding for three tumor registries (Iowa, LA, and Hawaii) to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEERs Residual Tissue Repository (RTR) for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs). Our 2nd SEER RTR will build TMAs for nearly 800 ovarian epithelial cancers (OEC). We will: 1) Assess whether tissue expression of certain molecular markers (Ki-67, P16, and P53) modify the effect of tumor grade on incidence and/or survival, and 2) Perform exploratory molecular studies to include protein and gene expression, methylation profiling, mismatch repair analysis, and tissue telomeres. Mortality Rate Generator Software (00390): The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, has been updated to include data through 2004 and is publicly available at (http://parsley.cit.nih.gov/ratecalc). Users can create customized maps according to cancer, age groups, sex, and race. US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382): DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk.

一般描述性研究（00350）：年轻女性的黑色素瘤发病率正在上升，这可能是由于紫外线辐射增加了对先前受保护的身体部位。我们考察了按年龄，性别和身体部位划分的黑色素瘤发病率趋势。描述性方法与年龄 - 周期性 - 霍特参数相辅相成，表明黑色素瘤在年轻女性的树干上优先增加。新兴的数据表明，皮肤恶性黑色素瘤（CMM）可能通过与间歇性与累积的日晒有关的癌症途径而产生。但是，关于暴露的时间和/或年龄仍然存在许多问题。我们检查了SEER数据中衰老对CMM发病率的影响。性别，组织病理学和解剖部位是CMM的年龄特异性效应修饰符。其他皮肤癌分析的重点是罕见的皮肤阑尾癌和皮肤腺样性囊性癌的发病率模式。男性乳腺癌是一种罕见的疾病，占全球所有乳腺癌诊断的1％。关于男性乳腺癌的多学科国际会议的重点是强调男性和女性乳腺癌之间的差异和相似之处。为了进一步增强我们对男性乳腺癌的理解，乳房国际组织和北美乳腺癌集团加入了制定国际男性乳腺癌计划并汇总流行病学数据，临床信息和肿瘤标本的努力。在对5,631例炎性乳腺癌（IBC）和447,767个非IBC的第一个乳腺癌病例中至少在诊断后生存2个月的侵入性对侧乳腺癌的分析，并报告了13个监测，流行病学和最终结果（SEER）（SEER）在1973年1月1日和2006年12月31日的癌症中，比一般癌症（SEER）在2006年1月31日，癌症中均高于2006年的癌症。非IBC。国际睾丸癌的发病率在北欧人群中仍然是最高的，在亚洲和非洲人群中，大多数人群中的发病率最低，静膜瘤和非肿瘤瘤的趋势通常相似。在过去的50年中，大多数人群的非心脏胃癌的年龄标准发病率稳步下降。但是，总比率是汇总措施，可能会掩盖重要年龄特异性趋势。我们分析了从1977年至2006年的SEER癌症发病率，发现除25至39岁的白人外，所有种族和年龄段的非心脏胃癌的发生率下降了。我们分析通过性别，种族/种族，解剖部位的结直肠癌发病率的分析，并且年龄发现，男性与女性的率比率从盲肠癌的大约1.8升至1.8，直肠癌的年龄增长，远端结肠癌的年龄增长最大，年龄在<50至1.4-1.9岁之间，年龄在老年人中<50至1.4-1.9，而越来越多的年龄段，又有种族/杂物，种族/差异;这些发现可能部分反映了筛查经验和获得医疗服务的差异，但也表明病因学因素可能起作用。人们一直担心在过去的二十年中爆炸性增长的细胞电话可能会增加患脑癌的风险。我们对Seer脑癌发病率的分析发现，在1992 - 2006年期间，特定年龄的趋势是向下或平坦的，除了20-29岁的女性中，其发生率显着提高。但是，这些增加仅适用于额叶癌，并且对于颞叶或顶叶癌或小脑的癌症，没有明显的增加，这涉及大脑部分，这些部分将高度暴露于来自细胞手机的射频辐射。这些数据不能支持蜂窝电话使用会导致脑癌的观点。 Burkitt淋巴瘤（BL）是独特的B细胞非霍奇金淋巴瘤，具有3种既定的临床 - 杂种病变异：流行，零星和与AIDS相关的BL。通过性别和种族对标准的横截面年龄标准化和年龄特异性发病率进行了分层，并补充了年龄段的模型。在敏感性分析中存在三/双峰发生率模式，包括许多HIV/AIDS病例的注册表以及特定于周期的同类群体特异性分析。接受放射治疗（RT）治疗霍奇金淋巴瘤（HL）的年轻女性患乳腺癌（BC）的风险很高。为了检查HL之后的BC特征是否与人口中的初级卑诗省有不同。我们在SEER数据库中2,645名HL幸存者中确定了166例公元前病例，这些案件在35岁之前被诊断出并用RT治疗。在15年的幸存者中，ER阴性/PR阴性与ER阳性/PR阳性BC的风险增加更大，高级肿瘤与低级肿瘤的风险更高。我们使用了30年的SEER发病率数据来研究一系列癌症的年龄特异性模式，发现人类生长，发育和致癌作用的复杂潜在生物学反映在整个年龄段的高度分散的模式中。在童年时期，器官系统的高峰年度大小增加与癌症发病率的高峰年相关。相反，在大多数成人发作的癌症中，它是外源毒素的暴露，维护和修复的失败，最后是正常细胞衰老过程中功能障碍，可能在这些恶性肿瘤的发展中起作用。特殊描述性研究（10348）：癌症流行病学中使用了年龄疗法（APC）分析，以模拟癌症率的趋势。我们开发了对两个独立原因特异性危害率进行比较APC分析的方法，假设APC模型适用于每个危害率。我们构建了线性假设检验，以确定两种危害是按队列，周期或年龄分层后绝对比例或成比例的。当给定比例危害模型似乎足够时，我们使用可识别的APC参数得出了相对危害的简单表达式。为了证明这些新方法的实用性，我们分析了美国黑人与白人的癌症发病率的选定癌症。 SEER特殊研究（00316）：2001年，SEER计划补充了三个肿瘤登记机构（爱荷华州，洛杉矶和夏威夷）的资金，以收集从集水区内的病理性实验室中丢弃的福尔马林固定，石蜡包裹的组织块。在示范项目中，我们使用现有的一组乳腺癌组织微阵列（TMA）验证了Seers残留组织存储库（RTR）的效用。我们的第二个先知RTR将为近800个卵巢上皮癌（OEC）建造TMA。我们将：1）评估某些分子标记物的组织表达（KI-67，p16和p53）是否修改了肿瘤等级对发病率和/或生存的影响，以及2）进行探索性分子研究，以包括蛋白质和基因表达，甲基化分析，甲基化谱分析，不匹配修复分析以及组织端粒。死亡率发电机软件（00390）：1950 - 94年发表于1999年的美国癌症死亡率地图集的在线版本已于1999年发布，已更新以纳入2004年的数据，并在（http://parsley.cit.nih.gov/ratecalc）上公开获取。用户可以根据癌症，年龄组，性别和种族创建定制的地图。美国军事癌症研究所（USMCI）/NCI合作研究计划（10382）：DCEG和USMCI研究人员正在分析超过900万活跃和退休的军事人员及其家人的数据，以估计癌症的比率，并研究职业暴露率和生活方式因素对癌症风险的影响。