Descriptive Studies and Record Linkage

描述性研究和记录链接

基本信息

批准号：
7593208
负责人：
William Anderson
金额：
$ 171.41万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7593208
关键词：
Age Age Distribution Alcoholic Liver Diseases Ambulatory Care Facilities Anatomy Area Asians Atlas of Cancer Mortality in the United States Bile Duct Diseases Biological Markers Birth Case-Control Studies Catchment Area Categories Caucasoid Race Censuses Characteristics Childhood Chronic Chronic Lymphocytic Leukemia Chronic Sinusitis Classification Scheme Clinical Colon Colon Carcinoma Computer software Country Data Data Analyses Data Linkages Data Set Databases Denmark Diagnosis Distal District of Columbia Etiology Evaluation Event Family Female Breast Carcinoma Fetal Distress Formalin Gaucher Disease Gender Gene Expression Genus Cola Goals Hemolytic Anemia Herpes zoster disease Heterogeneity Histologic Hospitalization Hospitals Immune Incidence Inflammatory Bowel Diseases Institutes Intrahepatic Cholangiocarcinoma Japan Japanese American Japanese Population Laboratories Life Life Style Link Lymphoma Malignant Bone Neoplasm Malignant Childhood Neoplasm Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of kidney Malignant neoplasm of lung Malignant neoplasm of pancreas Mammary Neoplasms Maps Medical Medical Surveillance Military Personnel Minority Molecular Molecular Profiling Multiple Myeloma Neuroblastoma Non-Hodgkin&apos s Lymphoma Occupational Occupational Exposure Outcome Paraffin Embedding Pathogenesis Pathologic Patients Pattern Perinatal Physical activity Pneumonia Poland Population Population Control Population Registers Prevention Publishing Race Rate Registries Relative Risks Renal carcinoma Reproduction Research Research Personnel Residual state Resources Risk Risk Factors Role SEER Program Sampling Seminoma Serum Site Small-Cell Lymphoma Stomach Carcinoma Subgroup Taxonomy Testicular Seminoma Tissue Microarray Tissues United States Department of Veterans Affairs Woman World Health Organization age group base cancer risk cohort early onset epidemiology study geographic difference malignant breast neoplasm malignant stomach neoplasm melanoma men mortality neoplasm registry outcome forecast parity programs prostatitis repository sarcoma sex socioeconomics soft tissue trend tumor

项目摘要

General descriptive studies (00350) We have used incidence and mortality data from the Surveillance, Epidemiology, and End Results (SEER) program to investigate demographic patterns. An analysis of SEER data for 26,758 cases of soft tissue sarcomas regardless of primary site diagnosed during 1978-2001 found that almost half (47.9%) arose in the soft tissues; rates varied markedly by race, gender, age, and histologic type, suggesting that these tumors may be etiologically distinct. The new WHO classification scheme considers B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) in an aggregate category (CLL/SLL); however, our analysis of the SEER data revealed similarities and dissimilarities in the incidence patterns for the two malignancies. Based on registry data from 41 populations in 14 countries, cohort-specific trends in testicular seminoma and non-seminoma appeared similar, suggesting that subtypes are epidemiologically and etiologically comparable. Additional analyses are assessing the incidence patterns according to anatomic subsite and histopathologic type for several cancers including esophageal cancer, stomach cancer, lung cancer, and kidney cancer. Special descriptive studies (10348) Epidemiology studies have generally viewed breast cancer as a single biologic entity with common etiology and unified pathogenesis. Accumulating data challenge this view, suggesting that breast tumors may be categorized into several groups with distinctive epidemiological features, clinical characteristics, and outcomes. Comparison of female breast carcinoma incidence rates among native Japanese in Osaka, Japanese-Americans, Whites and Blacks in the U.S. revealed age-specific incidence differences among Occidental and Asian breast cancer populations. Age-specific rates among women in the U.S. reflected bimodal early-onset and late-onset breast cancer populations, whereas rates in Japan had mostly early-onset age distributions-at-diagnosis. Using data from a population-based case-control study in Poland, results confirmed etiologic heterogeneity by age-at-onset for certain risk factors such as parity. Parity was protective for late-onset breast cancers, but a risk factor for early-onset tumors. The reversal of relative risks by age at onset is a qualitative (crossover) age interaction, suggesting that breast cancers are fundamentally divisible into at least two main types. The 1st breast cancer is early-onset and influenced by etiologic events, occurring early in reproduction life. The 2nd breast cancer is late-onset and impacted by life long carcinogenic exposures. SEER special studies (00316) Analysis of gene expression profiles in breast cancer have identified intrinsic molecular subtypes, which differ in risk factor profiles and prognosis. These advances in molecular taxonomy, prevention, and treatment create a need for establishing the incidence and prognosis of specific breast cancer subtypes in various populations. However, until recently, there were limited population-based resources for these estimates. In 2001, the SEER program supplemented tumor registries to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEERs Residual Tissue Repository for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs). Mortality Rate Generator Software (00390) The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, is available at http://www.nci.nih.gov/atlasplus. Users can create customized maps according to cancer, age groups, sex, and race. Evaluation of Disparities in District of Columbia (DC) (10301)Newly-emerging data from the population-based DC Cancer Registry provide a unique opportunity to investigate disparities in incidence rates according to demographic, geographic, and socioeconomic characteristics. Total cancer incidence was higher among blacks than whites by 53% among men and 2% among women. Record Linkage StudiesSweden and Denmark linked registries on hospital discharges and subsequent cancers (00560) A Danish case-control study of intrahepatic cholangiocarcinoma (IC) and population controls selected from the Danish Population Register were linked to the DHDR to obtain exposure/hospital data on prior hospitalizations. IC was significantly associated with alcoholic liver disease, chronic inflammatory bowel disease, and bile duct diseases. Swedish CER occupational study (02050) Using Swedish census data from 1960 and 1970, linked to the Swedish Cancer Registry for cancer ascertainment from Jan 1, 1971 to Dec 31, 1989, occupational physical activity was found to be associated with a decreased risk of colon cancer among Swedish men and women, particularly the proximal and middle parts of the colon among women and distal colon among men. Swedish childhood cancers study (00550) A study of childhood bone cancers in the Swedish birth registry dataset found several risk factors implicating complicated delivery and fetal distress. We are also studying perinatal risk factors for neuroblastoma. Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580) A cohort of 1,500 patients with Gaucher disease was found to have 2-3-fold increased risks of non-Hodgkin lymphoma, malignant melanoma and pancreas cancer, but no significant association with multiple myeloma or cancer overall. An analysis of medical risk factors for chronic lymphocytic leukemia (CLL) found increased risk associated with chronic sinusitis, pneumonia, Herpes zoster and simplex, auto-immune hemolytic anemia and prostatitis. US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382) DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk. The wealth of information, including more than 30 million serum samples, will allow valuable studies, including research on rare cancers, cancers common among younger men, and cancers that occur more frequently in minority populations

一般描述性研究（00350） 我们使用了监视，流行病学和最终结果（SEER）计划（SEER）计划的发病率和死亡率数据来研究人口统计学模式。对1978-2001诊断的主要部位的26,758例SECE数据的分析发现，软组织中出现了几乎一半（47.9％）。率因种族，性别，年龄和组织学类型而明显变化，表明这些肿瘤在病因上可能是不同的。新的WHO分类方案考虑了骨料类别（CLL/SLL）中的B细胞慢性淋巴细胞性白血病（CLL）和小淋巴细胞淋巴瘤（SLL）；但是，我们对SEER数据的分析揭示了这两个恶性肿瘤的发病率模式的相似性和差异。基于14个国家中41个人群的注册表数据，睾丸精子瘤和非肌瘤瘤的队列特异性趋势似乎相似，这表明亚型在流行病学和病理上是相当的。其他分析是根据解剖学的亚场和组织病理学类型评估多种癌症的发生率模式。 流行病学研究通常与单个生物学症状有关，并具有普通的eTeigation andity Etii andity antigiative and eTii eTii andity and Intigiative and Intigiative and Intigiation。积累数据挑战这种观点，表明乳腺肿瘤可能被归类为具有独特的流行病学特征，临床特征和结果的几个组。大阪，日裔美国人，白人和黑人的女性乳腺癌发病率的比较揭示了西方和亚洲乳腺癌种群中特定年龄的发病率差异。美国女性的年龄特异性发生了反映的双峰早期发作和晚期发作的乳腺癌种群，而日本的率主要是早期发作的年龄分布 - 诊断。使用来自波兰的基于人群的病例对照研究的数据，结果证实了对某些危险因素（例如平等）的年龄异质性的病因异质性。奇偶校验是对晚期乳腺癌的保护，但是早发肿瘤的危险因素。发病时年龄划分的相对风险逆转是一种定性（交叉）年龄相互作用，这表明乳腺癌从根本上可以分为至少两种主要类型。 1 st 乳腺癌是早期发作的，受病因事件的影响，发生在繁殖寿命的早期。 2 nd 乳腺癌是晚期发作的，并受到寿命长的致癌性暴露的影响。 对乳腺癌中基因表达谱分析的分析已经鉴定出内部分子子型，这些细胞属性差异有所不同，这些子型在风险因素和预后症中有所不同。分子分类，预防和治疗方面的这些进步需要确定各种种群中特定乳腺癌亚型的发生率和预后。但是，直到最近，对于这些估计，基于人群的资源有限。 2001年，SEER计划补充了肿瘤登记局，以从其集水区域内的病理实验室收集被丢弃的福尔马林固定，石蜡包裹的组织块。在一个示范项目中，我们使用现有的乳腺癌组织微阵列（TMA）（TMA）验证了Seers残留组织存储库的效用。 http://www.nci.nih.gov/atlasplus。用户可以根据癌症，年龄段，性别和种族创建定制的地图。 评估哥伦比亚特区（DC）（DC）（10301）（10301）来自基于人群DC癌症登记中心的新出现的数据，为根据人口统计学，地理，地理，地理，社会经济学和社会经济学来调查入射率的独特机会，提供了一个独特的机会。黑人的总癌症的发生率高于白人的53％，男性的总癌症的发病率高于53％，在女性中，癌症的发病率高。 DHDR获得有关先前住院的曝光/医院数据。 IC与酒精性肝病，慢性炎症性肠病和胆管疾病显着相关。 使用1960年和1970年的瑞典人口普查数据使用瑞典的人口普查数据，与1971年1月1日的癌症癌症相关的瑞典癌症与1971年1月1日，1989年的风险相关的瑞典人口普查数据，1989年，涉及到与癌症的风险相关。瑞典男性和女性中的癌症，尤其是女性和男性远端结肠的近端和中部。 瑞典儿童期癌症研究（00550） 对瑞典出生注册表中童年骨癌的研究研究，这些研究集中于几种危险的危险因素，暗感因素造成了多种危险因素。 We are also studying perinatal risk factors for neuroblastoma. Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580) A cohort of 1,500 patients with Gaucher disease was found to have 2-3-fold increased risks of non-Hodgkin lymphoma, malignant melanoma and pancreas cancer, but no significant与总体多发性骨髓瘤或癌症相关。对慢性淋巴细胞性白血病（CLL）的医疗危险因素的分析发现，与慢性鼻窦炎，肺炎，疱疹疱疹和单纯疱疹，自动免疫性溶血性贫血和前列腺炎有关的风险增加。 研究人员正在分析超过900万活跃和退休的军事人员及其家人的数据，以估计癌症率，并研究职业暴露和生活方式因素对癌症风险的影响。包括超过3000万血清样本在内的大量信息将允许有价值的研究，包括对罕见癌症，年轻男性常见的癌症的研究，以及在少数族裔人口中更频繁地发生的癌症