Descriptive Studies and Record Linkage

描述性研究和记录链接

• 批准号: 7733739
• 负责人: William Anderson
• 金额: $ 155.13万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733739
• 关键词: Acquired Immunodeficiency Syndrome; Age; Ambulatory Care Facilities; Anaplastic Lymphoma; Anatomy; Anemia; Apgar Score; Area; Arthritis; Atlas of Cancer Mortality in the United States; Autoimmune Diseases; B-Cell Acute Lymphoblastic Leukemia; Biological; Biological Markers; Biology; Birth; Body of uterus; Breast; Calendar; Cancer Etiology; Catchment Area; Categories; Censuses; Cervix Uteri; Characteristics; Childhood; Childhood Lymphoma; Classification; Clinical; Cohort Effect; Cohort Studies; Colon Carcinoma; Communicable Diseases; Computer software; Cutaneous Lymphoma; Data; Data Analyses; Data Linkages; Data Set; Databases; Denmark; Descriptive Epidemiology; Detection; Disease; Disease susceptibility; District of Columbia; Division of Cancer Epidemiology and Genetics; Epithelial ovarian cancer; Esophageal Adenocarcinoma; Esophagus; Ethnic group; Evaluation; Family; Family history of; Female Breast Carcinoma; Fetal Distress; Formalin; Gender; Geographic Locations; Hawaii; Heterogeneity; Hospitalization; Hospitals; Incidence; India; Inflammatory; Inpatients; Institutes; Iowa; Laboratories; Larynx; Life Style; Link; Liver; Localized; Lung; Lymphoma; Malignant Bone Neoplasm; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of male breast; Malignant neoplasm of ovary; Maps; Medical; Medical Surveillance; Military Personnel; Modeling; Monoclonal gammopathy of uncertain significance; Morphologic artifacts; Multiple Myeloma; National Cancer Institute; Neonatal; Neuroblastoma; Non-Hodgkin' s Lymphoma; Occupational; Occupational Exposure; Oral cavity; Osteoporosis; Outcome; Pancreas; Paraffin Embedding; Pathologic; Patients; Pattern; Personal Satisfaction; Pharyngeal structure; Physical activity; Plasmacytoma; Population; Pregnancy; Prostate; Publishing; Race; Rate; Registries; Renal Cell Carcinoma; Research; Research Personnel; Residual state; Respiratory distress; Risk; Risk Factors; Role; Rosa; SEER Program; Sexually Transmitted Diseases; Singapore; Site; Staging; Stomach; Subgroup; Survival Analysis; Sweden; T-Lymphocyte; Thyroid Gland; Tissue Microarray; Tissues; United Kingdom; United States; United States Department of Veterans Affairs; Update; Variant; Weight; Woman; age group; age related; base; cancer risk; cohort; geographic difference; male; malignant breast neoplasm; melanoma; men; mortality; neoplasm registry; programs; racial and ethnic; repository; sex; size; socioeconomics; trend; tumor; Acquired Immunodeficiency Syndrome; Age; Ambulatory Care Facilities; Anaplastic Lymphoma; Anatomy; Anemia; Apgar Score; Area; Arthritis; Atlas of Cancer Mortality in the United States; Autoimmune Diseases; B-Cell Acute Lymphoblastic Leukemia; Biological; Biological Markers; Biology; Birth; Body of uterus; Breast; Calendar; Cancer Etiology; Catchment Area; Categories; Censuses; Cervix Uteri; Characteristics; Childhood; Childhood Lymphoma; Classification; Clinical; Cohort Effect; Cohort Studies; Colon Carcinoma; Communicable Diseases; Computer software; Cutaneous Lymphoma; Data; Data Analyses; Data Linkages; Data Set; Databases; Denmark; Descriptive Epidemiology; Detection; Disease; Disease susceptibility; District of Columbia; Division of Cancer Epidemiology and Genetics; Epithelial ovarian cancer; Esophageal Adenocarcinoma; Esophagus; Ethnic group; Evaluation; Family; Family history of; Female Breast Carcinoma; Fetal Distress; Formalin; Gender; Geographic Locations; Hawaii; Heterogeneity; Hospitalization; Hospitals; Incidence; India; Inflammatory; Inpatients; Institutes; Iowa; Laboratories; Larynx; Life Style; Link; Liver; Localized; Lung; Lymphoma; Malignant Bone Neoplasm; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of male breast; Malignant neoplasm of ovary; Maps; Medical; Medical Surveillance; Military Personnel; Modeling; Monoclonal gammopathy of uncertain significance; Morphologic artifacts; Multiple Myeloma; National Cancer Institute; Neonatal; Neuroblastoma; Non-Hodgkin' s Lymphoma; Occupational; Occupational Exposure; Oral cavity; Osteoporosis; Outcome; Pancreas; Paraffin Embedding; Pathologic; Patients; Pattern; Personal Satisfaction; Pharyngeal structure; Physical activity; Plasmacytoma; Population; Pregnancy; Prostate; Publishing; Race; Rate; Registries; Renal Cell Carcinoma; Research; Research Personnel; Residual state; Respiratory distress; Risk; Risk Factors; Role; Rosa; SEER Program; Sexually Transmitted Diseases; Singapore; Site; Staging; Stomach; Subgroup; Survival Analysis; Sweden; T-Lymphocyte; Thyroid Gland; Tissue Microarray; Tissues; United Kingdom; United States; United States Department of Veterans Affairs; Update; Variant; Weight; Woman; age group; age related; base; cancer risk; cohort; geographic difference; male; malignant breast neoplasm; melanoma; men; mortality; neoplasm registry; programs; racial and ethnic; repository; sex; size; socioeconomics; trend; tumor

General descriptive studies (00350): Our updated and expanded analysis of esophageal adenocarcinoma incidence trends among U.S. whites found that rates increased 463% among men and 335% among women from 1975-79 to 2000-04; rates rose in all stage and age groups, indicating that these increases are real and not an artifact of surveillance. Renal cell cancer incidence rates continued to rise among all racial/ethnic groups in the United States, across all age groups, and for all tumor sizes, with the most rapid increases for localized stage disease and small tumors. Plasmacytoma incidence rates overall and by site were compared with those for multiple myeloma, and variations in the patterns according to race, gender, and age suggested underlying differences in clinical detection, susceptibility, disease biology and/or etiologic heterogeneity. An analysis of cancer incidence among Indians residing in different geographic regions around the world (India, Singapore, the United Kingdom, and the United States) found that rates for cancers of the colorectum, prostate, thyroid, pancreas, lung, breast and non-Hodgkin lymphoma were lowest in India, whereas rates for cancers of the oral cavity, esophagus, larynx, and cervix uteri were highest in India. Additional analyses are assessing the incidence patterns according to anatomic subsite and histopathologic type for several cancers including the oral cavity and pharynx, stomach, lung, prostate, and thyroid, and cutaneous lymphoma, childhood lymphoma and leukemia, Burkitt lymphoma, malignant melanoma, ovarian cancer, cervical cancer, and multiple myeloma. Special descriptive studies (10348): It is widely recognized that breast cancer incidence rates overall are higher among White than Black women. However, it is not generally appreciated that age-specific incidence rates are higher for Black women aged more than 40 years and higher for White women aged more than 40 years. This so-called Black to White ethnic crossover has been well-described, not fully understood, and sometimes viewed as an artifact. We used data from the National Cancer Institute"s SEER database to assess the validity of the Black to White ethnic crossover in the United States. The Black and White ethnic crossover was a robust feature in the SEER database. Amidst recent declines for female breast cancer, age-adjusted incidence rates may be increasing for male breast cancer in the United States (US) and elsewhere. However, age-adjusted temporal trends reflect an age-specific weighted average, which may be confounded with age-related biological and/or temporal effects (period and/or cohort). We, therefore, supplemented the descriptive epidemiology of male and female breast cancer with age-period-cohort (APC) models, simultaneously adjusted for age, calendar-period, and birth-cohort effects. Results showed that male and female breast cancers demonstrated similar secular trends but different age-related biology; i.e., relatively more late-onset, low grade, and ER positive tumors among men than women. SEER special studies (00316): In 2001, the SEER program supplemented three tumor registries (Iowa, LA, and Hawaii) to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEER"s Residual Tissue Repository for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs). Our 2nd SEER Residual Tissue Project will assess the population-based estimates for ovarian epithelial cancers (OEC). Where the breast project used an existing set of tissue microarrays, we will build the arrays for ovarian cancer, following a systematic pathologic review of all available ovarian cancer cases, i.e., approximately 1600. Mortality Rate Generator Software (00390): The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, is available at http://www.nci.nih.gov/atlasplus. Users can create customized maps according to cancer, age groups, sex, and race. The website is being updated to include data through 2004. Evaluation of Disparities in District of Columbia (DC) (10301): Newly-emerging data from the population-based DC Cancer Registry provide a unique opportunity to investigate disparities in incidence rates according to demographic, geographic, and socioeconomic characteristics. Total cancer incidence was higher among blacks than whites by 53% among men and 2% among women. Record Linkage Studies: Sweden and Denmark linked registries on hospital discharges and subsequent cancers (00560): A Danish cohort study of osteoporosis was selected from the Danish Hospital Discharge Registry (DHDR) to obtain exposure/hospital data and linked to the Danish Cancer Registry for cancer outcomes. Osteoporosis below age 70 was significantly associated with increased risks of cancers of the buccal cavity, esophagus, liver, pancreas and lung. We also analyzed the survival patterns of lymphoma patients with a family history of lymphoma. With the exception of T-cell anaplastic lymphoma, survival patterns for patients with CLL, HL, and NHL with a family history of lymphoma were similar to those for sporadic patients. Swedish CER occupational study (02050): Using Swedish census data from 1960 and 1970, linked to the Swedish Cancer Registry for cancer ascertainment from Jan 1, 1971 to Dec 31, 1989, occupational physical activity was found to be associated with a decreased risk of colon cancer among Swedish men and women. Swedish childhood cancers study (00550): A study of childhood bone cancers in the Swedish birth registry dataset found several risk factors implicating complicated delivery and fetal distress. For neuroblastoma, increased risks were also associated with neonatal respiratory distress, as well as maternal anemia during pregnancy, and low 1-minute APGAR score. Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580): A large study of medical risk factors for multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) in the Veterans Administration (VA) inpatient hospitalization database found increased risk associated with broad categories of autoimmune disorders, infectious diseases and inflammatory disorders. US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382): DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk.

一般描述性研究（00350）：我们对美国白人的食管腺癌发病率趋势的更新和扩展分析发现，从1975 - 79年到2000 - 04年，男性的发生率增加了463％，女性中有335％的速度增加了335％。所有阶段和年龄段的率上升，表明这些增加是真实的，而不是监视的伪像。在美国所有年龄段的所有种族/族裔中，肾细胞癌的发病率持续上升，并且对于所有肿瘤大小，对于局部舞台疾病和小肿瘤的速度最快。将整体浆细胞瘤的发病率与多种骨髓瘤进行比较，以及根据种族，性别和年龄的模式变化所表明的临床检测，易感性，疾病生物学和/或病因学异质性的潜在差异。对居住在世界各地不同地理区域（印度，新加坡，英国和美国）的印第安人之间癌症发病率的分析发现，结直肠，前列腺，甲状腺，胰腺，胰腺，肺，乳房，乳房，乳房和非霍奇金淋巴瘤的癌症的比率是印度的最高率和牛肉群的最低率在印度。其他分析是根据解剖学的近代和组织病理学类型评估多种癌症的发生率模式，包括口腔和咽部，胃，肺，前列腺和甲状腺，以及皮肤淋巴瘤，儿童淋巴瘤和白血病，Burkitt淋巴瘤，伯基特淋巴瘤，恶性糖浆，卵癌，牛var癌，corverical癌，兄弟癌。 特殊描述性研究（10348）：广泛认识到，白人妇女的乳腺癌发病率总体上比黑人女性高。但是，通常不理解的是，年龄超过40岁的黑人妇女的年龄特异性发病率更高，而年龄超过40岁的白人女性则更高。这种所谓的黑色至白色种族跨界已被很好地描述，尚未完全理解，有时被视为人工制品。 We used data from the National Cancer Institute"s SEER database to assess the validity of the Black to White ethnic crossover in the United States. The Black and White ethnic crossover was a robust feature in the SEER database. Amidst recent declines for female breast cancer, age-adjusted incidence rates may be increasing for male breast cancer in the United States (US) and elsewhere. However, age-adjusted temporal trends reflect an age-specific weighted average, which因此，与年龄相关的生物学和/或时间效应（时期和/或同龄人），我们补充了男性和女性乳腺癌的描述性流行病学，同时调整了年龄，日历 - 周期性和生育效果。与女性相比，男性的迟到，低级和ER阳性肿瘤（00316）。在一个演示项目中，我们使用现有的乳腺癌组织微阵列（TMA）（TMA）验证了SEER的残留组织存储库对分子标记的实用性。我们的第二个SEER残留组织项目将评估基于人群的基于人群的估计值，用于卵巢上皮癌（OEC）的现有乳房项目。审查所有可用的卵巢癌病例，即大约1600个。死亡率生成器软件（00390）：1950 - 94年在1999年发布的癌症死亡率的在线版本，可在http://www.nci.nih.nih.gov/atlasplus上使用。包括至2004年的数据。评估哥伦比亚特区（DC）（10301）的差异：基于人群的DC癌症注册表的新出现的数据为根据人口统计学，地理和社会经济特征提供了一个独特的机会来研究发病率的差异。黑人的总癌症发病率高于白人的男性53％，女性的总数高出2％。 创纪录的联系研究：瑞典和丹麦将医院出院的注册表与随后的癌症联系起来（00560）：从丹麦医院出院登记处（DHDR）中选择了丹麦骨质疏松症研究，以获得暴露/医院数据，并与丹麦癌症癌症有关。 70岁以下的骨质疏松症与颊腔，食道，肝脏，胰腺和肺的癌症风险增加显着相关。我们还分析了具有淋巴瘤家族史的淋巴瘤患者的生存模式。除T细胞肿瘤淋巴瘤外，患有淋巴瘤家族史的CLL，HL和NHL患者的存活模式与零星患者的家族史相似。 瑞典CER职业研究（02050）：使用1960年和1970年的瑞典人口普查数据与瑞典癌症登记处有关1971年1月1日至1989年12月31日的癌症癌症注册处，发现职业体育活动与瑞典男性和女性结肠癌的风险降低有关。 瑞典儿童期癌症研究（00550）：瑞典出生登记册中儿童骨癌的研究发现了几种危险因素，涉及复杂的分娩和胎儿痛苦。对于神经母细胞瘤，增加的风险也与新生儿呼吸窘迫以及怀孕期间的孕妇贫血有关，APGAR评分较低。 退伍军人管理医院数据库，患者治疗档案和门诊诊所文件（00580）：对多发性骨髓瘤（MM）和单克隆性伽马病的医疗风险因素的大量研究（MGUS）和单克隆性伽马病（MGU）的智能（MGU）（MGU）在体内施用（VA）的风险增加与内科医院数据相关的风险增加，并在范围内发现了较大的范围，并具有自动疾病的范围，自动疾病的自动疾病疾病与自动疾病相关。疾病。 美国军事癌症研究所（USMCI）/NCI合作研究计划（10382）：DCEG和USMCI研究人员正在分析超过900万活跃和退休的军事人员及其家人的数据，以估算癌症的速度，并研究职业暴露率和生活方式暴露和生活方式因素对癌症风险的影响。