TEM5 Ligand Hunt

TEM5 配体搜寻

• 批准号: 8157315
• 负责人: bradley d st croix
• 金额: $ 25.18万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157315
• 关键词: Endothelium; Gene Expression; Goals; Growth; Ligands; Physiological; Tumor Angiogenesis; tumorigenesis

Tumors are dependent upon new blood vessel formation, or angiogenesis, for expansive growth. Our prior analysis of gene expression in tumor endothelium led to the identification of a G-protein coupled receptor called TEM5. In an attempt to understand the role of TEM5 in angiogenesis and its importance for tumor growth, we previously embarked upon a hunt for its physiological ligand. Through a number of serendipitous events we have purified a factor that we now believe is not the ligand of TEM5 but is a very important biological factor that in our model system promotes tumor growth, tumor angiogenesis, and possibly cachexia. We are currently characterizing this factor and its role in tumorigenesis.

肿瘤的扩张生长依赖于新血管形成或血管生成。我们之前对肿瘤内皮基因表达的分析导致了一种名为 TEM5 的 G 蛋白偶联受体的鉴定。为了了解 TEM5 在血管生成中的作用及其对肿瘤生长的重要性，我们之前开始寻找其生理配体。通过许多偶然的事件，我们纯化了一种因子，我们现在认为它不是 TEM5 的配体，而是一个非常重要的生物因子，在我们的模型系统中促进肿瘤生长、肿瘤血管生成，并可能促进恶病质。我们目前正在表征该因素及其在肿瘤发生中的作用。