TEM5 Ligand Hunt

TEM5 配体搜寻

• 批准号: 8552707
• 负责人: bradley d st croix
• 金额: $ 47.56万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552707
• 关键词: Area; Blood Vessels; Cell surface; Endothelial Cells; Endothelium; Event; G-Protein-Coupled Receptors; Gene Expression; Goals; Growth; Ligands; Physiological; Role; angiogenesis; receptor; tumor; tumor growth; tumorigenesis

Tumors are dependent upon new blood vessel formation, or angiogenesis, for expansive growth. Our prior analysis of gene expression in tumor endothelium led to the identification of a G-protein coupled receptor called TEM5. In an attempt to understand the role of TEM5 in angiogenesis and its importance for tumor growth, we previously embarked upon a hunt for its physiological ligand. Through a number of serendipitous events we have now come across what appears to be a ligand for TEM5. We are currently characterizing this factor and its role in tumorigenesis.

肿瘤的扩张生长依赖于新血管形成或血管生成。 我们之前对肿瘤内皮基因表达的分析导致了一种名为 TEM5 的 G 蛋白偶联受体的鉴定。 为了了解 TEM5 在血管生成中的作用及其对肿瘤生长的重要性，我们之前开始寻找其生理配体。 通过一系列偶然事件，我们现在发现了似乎是 TEM5 配体的物质。 我们目前正在表征该因素及其在肿瘤发生中的作用。