The Cleveland Clinic Innovation Accelerator

克利夫兰诊所创新加速器

• 批准号: 8743250
• 负责人: PAUL E DICORLETO
• 金额: $ 180.92万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8743250
• 关键词: Academic Medical Centers; Address; Architecture; Area; Back; Basic Science; Blood; Build-it; Cardiovascular system; Clinic; Clinical; Collaborations; Complement; Development; Devices; Diagnosis; Diagnostic; Disease; Ensure; Funding; Generations; Goals; Health; Healthcare; Heart; Heart Diseases; Hematological Disease; Human; Institutes; Institution; Laboratories; Lead; Link; London; Lung; Lung diseases; Medical Device; Medical center; Mentors; Mission; National Heart, Lung, and Blood Institute; Occupations; Ohio; Patient Care; Patients; Pediatric Hospitals; Peer Review; Personal Satisfaction; Positioning Attribute; Prevention; Process; Public Health; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Secure; Seeds; Sleep; Sleep Disorders; Solutions; Staging; Technology; Therapeutic; Training; Translating; Translation Process; Trust; United States National Institutes of Health; Universities; Validation; Vision; arm; base; commercialization; experience; improved; innovation; pre-clinical; product development; programs; prototype; success; tool; Academic Medical Centers; Address; Architecture; Area; Back; Basic Science; Blood; Build-it; Cardiovascular system; Clinic; Clinical; Collaborations; Complement; Development; Devices; Diagnosis; Diagnostic; Disease; Ensure; Funding; Generations; Goals; Health; Healthcare; Heart; Heart Diseases; Hematological Disease; Human; Institutes; Institution; Laboratories; Lead; Link; London; Lung; Lung diseases; Medical Device; Medical center; Mentors; Mission; National Heart, Lung, and Blood Institute; Occupations; Ohio; Patient Care; Patients; Pediatric Hospitals; Peer Review; Personal Satisfaction; Positioning Attribute; Prevention; Process; Public Health; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Secure; Seeds; Sleep; Sleep Disorders; Solutions; Staging; Technology; Therapeutic; Training; Translating; Translation Process; Trust; United States National Institutes of Health; Universities; Validation; Vision; arm; base; commercialization; experience; improved; innovation; pre-clinical; product development; programs; prototype; success; tool

Cleveland Clinic (CC) and its partners Case Western Reserve University, Cincinnati Children's Hospital Medical Center, The Ohio State University and University of Cincinnati have a longstanding commitment and documented success in transitioning laboratory and clinical innovations into dramatic improvements in patient care, CC alone, via its commercialization arm CC Innovations (CCI), has generated 53 spin-off companies and $644 million in equity financing in the past decade; however CCI has a focus on more mature programs and does not reach back into the research pipeline. Also, contributing to commercialization success of the applicant institutions has been the establishment of the state-funded Global Cardiovascular Innovation Center (GCIC) that has a mission of advancing late-stage cardiovascular innovations, i.e., "shovel ready" opportunities with rapid job creation potential. The applicant consortium has now come together to address an unmet need by proposing a new Center (Cleveland Clinic Innovation Accelerator, CCIA) with an overall goal of propelling early-stage projects forward and educating researchers to be full partners in transforming their discoveries into high-impact advances in patient care. The proposed Center will enhance and coordinate the existing resources of the five partnering institutions to advance the very strong pipeline of laboratory discoveries and technical innovations generated every year in NHLBI mission areas (over 250 NHLBI-funded projects). This application has three specifics aims: (1) To create the CCIA - a self-sustainable, multi-institutional consortium focused on translating early innovations in NHLBI mission areas into advanced solutions for improving global patient care. CCIA will complement the mission of the GCIC by reaching earlier into the discovery and development pipeline in order to address the gap between discovery research and validation/pre-clinical development. (2) To select through rigorous peer-review commercially-promising NHLBI funded projects that will receive funds and expert project management. Projects shall span the technology range of diagnostics, devices, therapeutics and tools. (3) To create a nationally accessible institute for educating and mentoring researchers, clinicians and developers in biomedical innovation and entrepreneurism. The Center will provide experience-based training to cultivate a growing cadre of commercially successful innovators. Generation of the CCIA will thus create a self-sustainable engine for propelling a large pipeline of NHLBI-related research discoveries into advances in human health.

克利夫兰诊所（CC）及其合作伙伴Case Western Reserve University，辛辛那提儿童医院 俄亥俄州立大学医学中心和辛辛那提大学有长期的承诺， 记录了将实验室和临床创新转变为巨大改善的成功 患者护理，单独通过其商业化臂CC创新（CCI）的患者护理，已经产生了53个衍生 在过去的十年中，公司和6.44亿美元的股权融资；但是CCI专注于更多 成熟的程序，没有回到研究管道。另外，有助于商业化 申请人机构的成功是建立了国家资助的全球心血管 创新中心（GCIC）的使命是前进后期心血管创新，即铲子 现成的“具有快速创造就业潜力的机会。申请人财团现在已经聚在一起 通过提出一个新中心（克利夫兰诊所创新加速器，CCIA）来满足需求 推动早期项目前进并教育研究人员成为正式合作伙伴的总体目标 将他们的发现转变为患者护理方面的高影响力进步。拟议的中心将增强 并协调五个合作机构的现有资源，以促进非常强大的渠道 每年在NHLBI任务领域产生的实验室发现和技术创新（超过250 NHLBI资助的项目）。该应用程序具有三个具体目的：（1）创建CCIA-可自我维持的， 多机构财团致力于翻译NHLBI任务领域的早期创新 进入改善全球患者护理的高级解决方案。 CCIA将补充GCIC的任务 到达发现和开发管道的早期，以解决发现之间的差距 研究与验证/临床前开发。 （2）通过严格的同行评估商业概述 NHLBI资助了将获得资金和专家项目管理的项目。项目应跨越 诊断，设备，治疗和工具的技术范围。 （3）创建一个在全国范围内访问的 教育和指导研究人员，临床医生和开发人员生物医学创新和开发人员 企业家主义。该中心将提供基于经验的培训，以培养越来越多的干部 商业上成功的创新者。因此，CCIA的产生将为 推动大量与NHLBI相关的研究发现人类健康的进步。