Core D: Neurocircuitry and Behavior Core

核心 D：神经回路和行为核心

• 批准号: 10238634
• 负责人: VINCENT A MAGNOTTA
• 金额: $ 23.76万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-16 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10238634
• 关键词: Address; Adult; Age; Animal Model; Animals; Behavior; Behavioral; Behavioral Assay; Bioinformatics; Brain; Brain imaging; Child; Clinic; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Collaborations; Communities; Conceptions; Country; Data; Data Set; Development; Diagnosis; Elderly; Ensure; Equipment; Experimental Designs; Family; Fostering; Funding; Hawks; Human; Image; Image Analysis; Imaging Device; Imaging Techniques; Individual; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; Iowa; Knowledge; Laboratories; Laboratory Finding; Laboratory Personnel; Learning; Longevity; Manuals; Memory; Metabolism; Modality; Monitor; Neurosciences; Physiologic pulse; Prevention; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural Population; Scientist; Services; Sleep; Social Interaction; Specific qualifier value; Structure; System; Technology; Training; Transcranial magnetic stimulation; Translating; Translations; Universities; analysis pipeline; bioimaging; cognitive change; cost effectiveness; data management; design; disability; experimental study; flexibility; human model; laboratory experience; neonate; neural circuit; neuroimaging; novel; programs; quality assurance; research study; rural area; service utilization; tool; translational approach

PROJECT SUMMARY: NEUROCIRCUITRY AND BEHAVIOR CORE (NBC) The primary objective of the Neurocircuitry and Behavior Core (NBC) is to provide state-of-the-art services that foster studies of intellectual and developmental disability (IDD) across the lifespan—from conception to adulthood, tailored to a rural population. The Core will support research projects affiliated with the Hawk- IDDRC that utilize both animals and humans as well as those that cross-fertilize a translational approach to the study of IDD from a lifespan perspective. The Core is made up of two units: 1) Neuroimaging Division (NID) and 2) Neural Circuits and Behavior Division (NCBD). The NID will assist in the development, implementation, and completion of neuroimaging research studies in animal models as well as humans. Neuroimaging modalities will focus on imaging techniques to assess brain structure, function, and metabolism. The resources provided will include expertise in the following aspects of brain imaging: a) development of novel imaging tools, pulse sequences, and equipment; b) implementation of protocols for image acquisition; c) implementation and deployment of standard image analysis pipelines; d) development of novel image analysis strategies; and e) data management, bioinformatics, and statistical support for imaging data. The NCBD will provide expertise in neural circuit function, behavior (e.g. social interaction, sleep), and cognition (e.g. learning and memory) in animal models and humans using tools that are often not available within individual laboratories. For studies using animal models, the NCBD will provide facilities and services to aid investigators performing behavioral assays. For human studies, the NCBD has significant expertise in studying human behavior and cognition across the lifespan and will design and implement cognitive paradigms to study neural circuits, which can be applied to individuals with intellectual and developmental disabilities as well as controls. Finally, the NID and NCBD are able to conduct experiments as requested by investigators, or will provide the necessary training to enable laboratory personnel to perform experiments in the facility. The NBC will integrate and capitalize upon strong existing resources currently available at the University of Iowa including the Iowa Institute for Biomedical Imaging (IIBI) and the Iowa Neuroscience Institute (INI). Tools that are developed as part of the NBC will be shared with IDD investigators across the country. The NBC will support 27 federally funded projects ($11.3 million per year) and will build upon strong existing collaborations between basic scientists who use animal models and clinical scientists engaged in human brain studies. In addition, the NBC will help strengthen the relationship between scientists and the IDD community and their families, many of whom live in rural areas, helping foster collaborations that will enable a better understanding of IDD from a lifespan perspective.

项目摘要：神经回路和行为核心 (NBC) 神经回路和行为核心 (NBC) 的主要目标是提供最先进的服务， 促进对整个生命周期中智力和发育障碍（IDD）的研究——从受孕到 为农村人口量身定制的成年期项目将支持与 Hawk 相关的研究项目。 IDDRC 利用动物和人类以及交叉转化方法来实现 从寿命角度研究 IDD 的核心由两个部门组成： 1) 神经影像部门 (NID) 2) 神经回路和行为部门 (NCBD) 将协助开发， 实施并完成动物模型和人类的神经影像学研究。 神经影像学模式将侧重于评估大脑结构、功能和新陈代谢的成像技术。 提供的资源将包括脑成像以下方面的专业知识： 新颖的成像工具、脉冲序列和设备；b) 图像采集协议的实现； 标准图像分析流程的实施和部署；d) 新颖图像分析的开发； 策略；以及 e) NCBD 将提供数据管理、生物信息学和统计支持。 提供神经回路功能、行为（例如社交、睡眠）和认知（例如学习）方面的专业知识 和记忆）在动物模型和人类中使用个体中通常不可用的工具 对于使用动物模型的研究，NCBD 将提供设施和服务来帮助研究人员。 对于人类研究，NCBD 在研究人类方面拥有丰富的专业知识。 整个生命周期的行为和认知，并将设计和实施认知范式来研究神经 电路，可应用于有智力和发育障碍以及控制能力的个体。 最后，NID 和 NCBD 能够按照调查人员的要求进行实验，或者提供 必要的培训，使实验室人员能够在设施中进行实验。 NBC 将整合并利用大学现有的强大资源 爱荷华州包括爱荷华生物医学成像研究所 (IIBI) 和爱荷华神经科学研究所 (INI)。 作为 NBC 的一部分开发的数据将与全国各地的 IDD 调查人员共享。 支持 27 个联邦资助的项目（每年 1130 万美元）并将以现有的强有力合作为基础 使用动物模型的基础科学家和从事人脑研究的临床科学家之间。 此外，NBC 将帮助加强科学家和 IDD 社区及其他们之间的关系 许多家庭生活在农村地区，帮助促进合作，以便更好地了解 从生命周期的角度来看IDD。