Neurobiological bases of paternal nurturance

父亲养育的神经生物学基础

基本信息

批准号：
8837662
负责人：
JAMES K RILLING
金额：
$ 18.21万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-15 至 2017-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In modern, western societies like ours, being raised without a father is associated with a host of negative developmental outcomes for children, including substance abuse, aggression and conduct disorder, dropping out of school and risky sexual behavior in adolescence. When fathers are present, however, they are not always helpful, and a small minority are even abusive. On the other hand, children raised by sensitive, nurturing fathers have better cognitive, behavioral, social and psychological outcomes. The proposed project will investigate the neurobiology underlying sensitive fathering and determine whether a pharmacological intervention can enhance it. The first aim is to investigate the relationship between fathers' neural responses to infant picture and cry stimuli and actual behavior of fathers in everyday life as assessed by the Electronic Activated Recorder (EAR), a portable digital audio recorder that periodically records brief snippets of ambient sounds and unobtrusively samples acoustic observations of participants' momentary social environments and interactions within the natural flow of their lives. This aim will use previously collected EAR data from 60 fathers of 1-3 year old children to code several measures of paternal behavior. Measures of paternal behavior will then be correlated with previously collected neuroimaging data from the same fathers. Aim 2 will determine if intranasal OT or AVP alter paternal neural responses to own child picture and cry stimuli. Thirty fathers with 1- 3 year old children will be imaged with fMRI as they view pictures of their own and unknown children and as they listen to unknown infant cry stimuli. Fathers will be scanned on two separate occasions; once under the influence of OT (n=15) or AVP (n=15), and once under the influence of a placebo. Order of administration will be counterbalanced across subjects. Ultimately, it is hoped that interventions like these will improve children's mental and physical health by virtue of their effects on the bran physiology and behavior of at-risk fathers (e.g., abusive fathers, fathers with post-partum depression).

描述（由申请人提供）：在像我们这样的现代西方社会中，没有父亲的成长与儿童的许多负面发展结果有关，包括滥用药物，侵略和行为障碍，辍学和青少年的风险性行为。但是，当父亲出现时，他们并不总是有帮助的，而少数人甚至虐待。另一方面，通过敏感，养育父亲抚养的孩子具有更好的认知，行为，社会和心理成果。拟议的项目将研究敏感父亲的神经生物学，并确定药理学干预是否可以增强它。第一个目的是研究父亲对婴儿图片和哭泣刺激的神经反应与父亲在日常生活中的实际行为之间的关系，这是通过电子激活录像机（EAR）评估的，这是一种便携式数字音频录像机，该录音师定期记录了短暂的环境声音的摘要，并毫不客气地示例了参与者在自然的社会互动和自然互动中的自然互动。这个目标将使用先前收集的耳朵来自1-3岁儿童的60名父亲的数据编写了多种父亲行为的措施。然后，父亲行为的度量将与先前收集的同一父亲的神经成像数据相关。 AIM 2将确定鼻内OT或AVP是否改变了对自己的儿童图片和哭泣刺激的父亲神经反应。有1-3岁孩子的三十个父亲将通过fMRI成像，因为他们查看自己和未知的孩子的照片，并听取不知名的婴儿哭泣刺激。父亲将在两个不同的场合扫描。一旦受到OT（n = 15）或AVP（n = 15）的影响，并且在安慰剂的影响下。行政顺序将在主题上平衡。最终，希望这样的干预措施能够通过对高危父亲的麸皮生理学和行为的影响（例如虐待父亲，后果抑郁症的父亲）的影响来改善儿童的身心健康。