CARDIOVASCULAR DISEASE AND MICROVASCULAR DYSFUNCTION IN FAT-FED RHESUS MONKEYS

脂肪喂养恒河猴的心血管疾病和微血管功能障碍

• 批准号: 8173225
• 负责人: KEVIN L GROVE
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173225
• 关键词: Accounting; Blood capillaries; Cardiovascular Diseases; Cardiovascular system; Clinical; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Detection; Diabetes Mellitus; Diabetic Angiopathies; Diet; Disease; Early Diagnosis; Early identification; Fatty acid glycerol esters; Functional disorder; Funding; Grant; Hyperglycemia; Institution; Insulin Resistance; Macaca mulatta; Methods; Morbidity - disease rate; Obesity; Organ; Pathogenesis; Patients; Perfusion; Peripheral; Peripheral Vascular Diseases; Protocols documentation; Quality of life; Research; Research Personnel; Resources; Source; Techniques; Therapeutic Intervention; Tissues; Ultrasonography; United States National Institutes of Health; capillary; feeding; high risk; mortality; nonhuman primate; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular complications account for the vast majority of the mortality and morbidity associated with diabetes (DM). These complications can be broadly categorized as macrovascular and microvascular. Microvascular complications of DM often have devastating effects on the quality of life and survival for patients with diabetes. It is now well recognized that many of microvascular complications are directly related to the degree of hyperglycemia and insulin resistance. However, our understanding of the pathogenesis and appropriate treatment of these disorders is rudimentary. Early detection of microvascular abnormalities will be useful for identifying patients with DM, insulin resistance, or obesity who are at high risk for developing major end-organ complications and who could benefit from therapeutic intervention. A method for routinely assessing microvascular flow reserve could also be useful for early identification of patients with peripheral vascular disease who are candidates for revascularization or other treatments, similar to protocols that are currently employed for the detection of coronary artery disease. Despite the great clinical need, a reliable, non-invasive method capable of assessing perfusion of peripheral tissues at the microvascular or capillary level in patients is currently not available. The overall aim of this proposal is to characterize the microvascular complications are associated with diet induced obesity/insulin resistance in the nonhuman primate (NHP) and that these abnormal responses can be assessed by contrast-enhanced ultrasound (CEU). These studies are using a combination of noninvasive techniques to characterize the level of cardiovascular disease in rhesus macaques chronically consuming a high fat diet.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 心血管并发症占糖尿病（DM）相关死亡率和发病率的绝大多数。这些并发症可大致分为大血管并发症和微血管并发症。糖尿病的微血管并发症常常对糖尿病患者的生活质量和生存造成破坏性影响。现在人们普遍认识到，许多微血管并发症与高血糖和胰岛素抵抗的程度直接相关。然而，我们对这些疾病的发病机制和适当治疗的了解还很初级。 早期检测微血管异常将有助于识别患有糖尿病、胰岛素抵抗或肥胖的患者，这些患者发生主要终末器官并发症的风险较高，并且可以从治疗干预中受益。常规评估微血管血流储备的方法也可用于早期识别患有周围血管疾病的患者，这些患者是血运重建或其他治疗的候选者，类似于目前用于检测冠状动脉疾病的方案。尽管临床需求很大，但目前还没有一种能够评估患者微血管或毛细血管水平外周组织灌注的可靠、非侵入性方法。该提案的总体目标是表征非人类灵长类动物（NHP）中与饮食引起的肥胖/胰岛素抵抗相关的微血管并发症，并且这些异常反应可以通过对比增强超声（CEU）进行评估。这些研究结合使用非侵入性技术来表征长期食用高脂肪饮食的恒河猴的心血管疾病水平。