Neurobiological and Genetic Correlates of Cooperative Behavior

合作行为的神经生物学和遗传相关性

• 批准号: 7713847
• 负责人: JAMES K RILLING
• 金额: $ 36.81万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7713847
• 关键词: AVPR1A gene; Algorithms; Anatomy; Autistic Disorder; Behavior; Biological; Brain; Brain region; Brain scan; Computers; Cooperative Behavior; DNA; DNA analysis; DRD4 gene; Data; Decision Making; Diffusion Magnetic Resonance Imaging; Dopamine Receptor; Double-Blind Method; Economics; Exons; Figs - dietary; Frequencies; Functional Magnetic Resonance Imaging; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Goals; Human; Image; Individual; Intranasal Administration; Investigation; MRI Scans; Measures; Mental disorders; Minisatellite Repeats; Neurobiology; Neuropeptides; Neurotransmitter Receptor; Outcome; Oxytocin; Oxytocin Receptor; Patient Self-Report; Personality Disorders; Placebo Control; Placebos; Play; Population; Prefrontal Cortex; Prisoner' s Dilemma; Randomized; Route; Saliva; Sampling; Scanning; Self-Administered; Sexual Partners; Social Behavior; System; Testing; Trust; Variant; Vasopressin Receptor; Vasopressins; base; computer program; depression; emotional factor; gray matter; interest; morphometry; neural model; placebo controlled study; psychopathic personality; research study; response; serotonin transporter; social; social attachment; social cooperation; white matter

DESCRIPTION (provided by applicant): The overall objective of this project is to explore the biological bases of individual variation in cooperative social behavior among normal subjects, with the goal of developing hypotheses to explain more extreme variation that manifests as mental illness. Cooperative behavior will be measured in an interactive social task known as the Prisoner's Dilemma (PD) Game. There are four specific aims. Aim 1 is to examine the relationship between individual variation in cooperative behavior and individual variation in brain function during the PD game. This will be accomplished by imaging subjects' brains with fMRI as they play an iterated Prisoner's Dilemma Game with each of two assumed human partners. These data will allow us to evaluate an existing model of the neural systems that facilitate and inhibit cooperation. Aim 2 is to examine the relationship between individual variation in cooperative behavior and individual variation in prefrontal cortex anatomy. This aim will involve acquiring a structural MRI scan from each subject to measure morphometric variation, as well as a diffusion tensor imaging (DTI) brain scan to measure white matter integrity. Aim 3 is to investigate the impact of intranasal oxytocin and vasopressin, neuropeptides associated with social bonding, on cooperative behavior and associated brain activity. In this placebo-controlled, double-blind experiment, subjects will be randomized to one of three conditions: intranasal oxytocin administration, intranasal vasopressin administration, or intranasal placebo administration. Functional brain activity and behavior will be compared across treatment groups. Aim 4 is to examine the relationship between individual variation in cooperative behavior and individual genetic variation. Saliva samples will be collected from each subject for analysis of genes hypothesized to have an influence on cooperative social behavior. Ultimately, these data will identify factors that contribute to trust and its reciprocation which are essential components of cooperative social behavior. Trust and its reciprocation are essential components of healthy interpersonal relationships, as evidenced by several psychiatric disorders in which they are lacking, including autism, depression, psychopathic personality disorder and several axis II personality disorders. By identifying factors that influence cooperative behavior in a normal population, this project will generate hypotheses as to the causes of more severe variation associated with mental illness.

描述（由申请人提供）：该项目的总体目的是探索正常受试者之间合作社会行为的个体变异的生物学基础，目的是开发假设，以解释表现为精神疾病的更极端变化。合作行为将以称为囚犯的困境（PD）游戏的互动社会任务来衡量。有四个具体目标。目的1是检查合作行为的个体变异与PD游戏中大脑功能的个体变异之间的关系。这将通过通过fMRI进行成像的大脑来实现，因为他们与两个假定的人类伴侣中的每一个都进行了迭代囚犯的困境游戏。这些数据将使我们能够评估促进和抑制合作的神经系统的现有模型。目的2是检查合作行为的个体变异与前额叶皮质解剖学中个体变异之间的关系。该目标将涉及从每个主题中获取结构性MRI扫描以测量形态计量学变化以及扩散张量成像（DTI）脑扫描以测量白质完整性。 AIM 3是研究鼻内催产素和加压素，与社会粘结相关的神经肽，对合作行为和相关大脑活动的影响。在这个安慰剂对照的双盲实验中，受试者将被随机分为三种条件之一：鼻内催产素的给药，鼻内加压素给药或鼻内安慰剂给药。在治疗组之间将比较功能性的大脑活动和行为。目标4是检查合作行为中个体变异与个体遗传变异之间的关系。将从每个主题中收集唾液样本，以分析假设对合作社会行为有影响的基因。最终，这些数据将确定导致信任及其往复的因素，这是合作社会行为的重要组成部分。信任及其往复是健康的人际关系的重要组成部分，这是由于几种精神疾病所证明的，其中包括自闭症，抑郁症，精神病性人格障碍和几种AXIS II人格障碍。通过确定影响正常人群中合作行为的因素，该项目将对与精神疾病相关的更严重变化的原因产生假设。