Vasopressin Effects on Emotional Social Communication

加压素对情感社交沟通的影响

• 批准号: 7988381
• 负责人: JAMES K RILLING
• 金额: $ 20.23万
• 依托单位: BOWDOIN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7988381
• 关键词: Affect; Anger; Animal Model; Antisocial Personality Disorder; Argipressin; Autistic Disorder; Behavior; Biological Neural Networks; Brain; Clinical; Communication; Disease; Dose; Emotional; Emotional Disturbance; Evolution; Face; Facial Expression; Female; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Gender; Genotype; Homologous Gene; Human; Individual; Individual Differences; Knowledge; Measures; Molecular; Peptides; Personality Disorders; Play; Population; Process; Promoter Regions; Receptor Gene; Regulation; Role; Signal Transduction; Smiling; Social Behavior; Social Environment; Social Interaction; Specificity; Stimulus; Symptoms; System; Techniques; Testing; Translating; Variant; Vasopressins; Vasotocin; Vertebrates; Woman; Work; affiliative behavior; anti social; gene therapy; insight; male; men; neurochemistry; novel; public health relevance; receptor; relating to nervous system; research study; response; sex; social; social communication

DESCRIPTION (provided by applicant): Arginine vasopressin (AVP) and related peptides have profound influences on social behaviors in vertebrates, particularly on emotional aggressive and affiliative interactions between individuals. Although we have recently shown that AVP can promote antisocial responses towards same-sex social stimuli in men and affiliative responses towards same-sex social stimuli in women, we do not yet know if there are sexually dimorphic AVP circuits that promote different social responses in the sexes, or rather if AVP's antisocial and affiliative effects depend on social context, specifically whether the social stimulus is male or female. The first aim of this application is therefore to measure the effects of intranasal AVP on emotional responses to same and other sex faces in men and women to see if AVP produces antisocial effects towards males and affiliative effects towards females, or rather if AVP uniformly promotes antisocial responses in males and affiliative responses in females. This will be done by measuring the effects of AVP on somatic responses associated with anger and threat (contractions of the corrugator supercilii) and with affiliation (contractions of the zygomaticus major, which control smiling) when subjects view the faces of same and other sex individuals, and by measuring the effects of AVP on perceptual responses to those faces, particularly on ratings of friendliness / approachability. We will also determine the dose-responsiveness for these effects, and determine if the magnitude of AVP's antisocial and/or affiliative effects depend on background genotype, particularly on allelic variations in the polymorphic RS3 promoter region of the AVP V1a receptor gene. Finally, we will identify regions in the brain where responses to those social stimuli change as a function of AVP administration. Together, these studies will elucidate the context and gender specificity of AVP's effects on emotional social communication in humans, as well as the molecular and neuroanatomical mechanisms associated with those effects. Ultimately, these studies will not only increase our understanding of the neurochemical mechanisms associated with normal social / emotional regulation in humans, but also our understanding of how dysfunctions within one of those systems may contribute to disorders characterized by social / emotional disturbances. PUBLIC HEALTH RELEVANCE: By determining if arginine vasopressin (AVP) can influence emotional social communication in men and women, particularly if it promotes antisocial and/or affiliative responses to social stimuli in men and women, the studies associated with this application will ultimately help us better understand and treat individuals with disorders that affect emotional social regulation, most notably those with autism and/or antisocial personality disorder. In fact, these studies could ultimately help develop pharmacological and/or genetic therapies that could help alleviate some of the otherwise intractable symptoms associated with these disorders.

描述（由申请人提供）：精氨酸加压素（AVP）和相关肽对脊椎动物的社会行为有深远的影响，尤其是对个体之间的情感侵略性和从属关系。尽管我们最近表明，AVP可以促进男性对同性社会刺激的反社会反应以及对女性同性社会刺激的隶属反应，但我们尚不知道是否存在性别二态AVP循环会促进性别中不同的社交反应，而不是AVP的抗异性和社会刺激，是否依赖于社交或社会刺激。因此，该应用的第一个目的是衡量鼻内AVP对男性和女性对同一和其他性别面孔的情绪反应的影响，以查看AVP是否对男性产生反社会作用，以及对女性的隶属作用，或者是否统一地促进了女性的男性和婚姻反应。这将通过测量AVP对与愤怒和威胁（瓦楞纸王的收缩）相关的躯体反应的影响，并与隶属关系（Zygomaticus Major的收缩，控制微笑的宫缩），当受试者查看相同和其他性别的人的面孔时，以及通过对这些面孔的高度响应的影响，特别是对这些面孔的影响，特别是对这些面孔的影响，特别是对这些面孔的效果。我们还将确定这些作用的剂量反应性，并确定AVP的反社会和/或隶属作用的大小是否取决于背景基因型，尤其是AVP V1A受体基因的多态性RS3启动子区域的等位基因变异。最后，我们将确定大脑中对这些社会刺激的反应随着AVP管理的函数而改变的区域。总之，这些研究将阐明AVP对人类情绪社交交流的影响以及与这些影响相关的分子和神经解剖学机制的影响和性别特异性。最终，这些研究不仅会增加我们对与人类正常社会 /情绪调节相关的神经化学机制的理解，而且我们对其中一个系统中的功能障碍的理解可能导致以社会 /情感障碍为特征的疾病。 公共卫生相关性：通过确定精氨酸加压素（AVP）是否会影响男性和女人的情感社交沟通，特别是如果它促进对男性和女人的社会刺激的反社会和/或会员反应，与此应用相关的研究最终将帮助我们更好地理解和对待情感社交调节的障碍，并以自动和/或自动化的态度对待情感社交监管，以治疗自动和/或或或或抗拒的人。实际上，这些研究最终可能有助于开发药理学和/或基因疗法，以帮助减轻与这些疾病相关的一些原本棘手的症状。