Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder

边缘性人格障碍社交功能障碍的神经行为机制

基本信息

批准号：
10088478
负责人：
Brooks Casas
金额：
$ 64.12万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10088478
关键词：
Address Affect Aggressive behavior Behavior Behavioral Biological Borderline Personality Disorder Characteristics Clinical Computer Models Control Groups Corpus striatum structure Cost of Illness Data Decision Making Diagnostic Disease Etiology Evaluation Feeling suicidal Functional Magnetic Resonance Imaging Functional disorder Goals Grant Human Hypersensitivity Impairment Impulsivity Individual Investigation Lateral Lead Learning Mental Health Modeling Neurosciences Outcome Parietal Lobe Participant Play Prefrontal Cortex Prevalence Process Punishment Rewards Risk Risk Assessment Role Scanning Services Signal Transduction Social Interaction Social outcome Testing Trust Woman Work base behavioral economics design disorder control distrust dyadic interaction emotion dysregulation epidemiologic data expectation experience hemodynamics men neurobehavioral neuroimaging neuromechanism phenomenological models physically handicapped preference psychologic relating to nervous system response social social deficits social expectations social learning social relationships

项目摘要

PROJECT SUMMARY Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).

项目概要边缘性人格障碍（BPD）是一种严重的心理健康状况，会导致严重的心理健康问题。和身体残疾。边缘性人格障碍临床表现的主要特征包括情感失调、冲动和不稳定的关系。虽然这些特征在经典中得到了证实社会关系，BPD 社会决策的神经行为病因学受到的限制尽管人际关系功能障碍在该疾病的表达中发挥着重要作用，但仍进行了调查。为了解决这一差距，该提案的总体目标是详细说明行为、计算和神经 BPD 中社会决策中三种候选人异常的潜在过程：(i) 风险偏差做出有关社会伙伴的决定时进行评估； (ii) 对社会预测错误高度敏感奖惩; (iii) 与攻击相关的社交学习异常。因此，我们结合得很好—— 从决策神经科学到功能磁共振成像的特色互动游戏对人际交往的生物学基础形成敏感而具体的神经机械学理解边缘性 PD 损伤。具体来说，我们在 BPD 中检查：（i）潜在风险的神经机制社会和非社会决策的偏好（目标 1）； (ii) 社会的神经机制奖励/惩罚敏感性（目标 2）； (iii) 导致人际冲动的神经机制攻击性（目标 3）。