Sarcopenia as a Predictor of Hospital-Associated Disability in Older Adults

肌肉减少症是老年人医院相关残疾的预测因素

• 批准号: 10115975
• 负责人: James Andrews
• 金额: $ 26.11万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115975
• 关键词: Activities of Daily Living; Acute; Administrative Supplement; Aging; Alzheimer' s disease related dementia; American; Architecture; Area; Award; Cessation of life; Cohort Studies; Dementia; Development; Dual-Energy X-Ray Absorptiometry; Elderly; Enrollment; Funding; Geriatrics; Goals; Gold; Grant; Hand Strength; Hip region structure; Hospitalization; Hospitals; Independent Living; Individual; Infrastructure; Knee; Measures; Mentored Patient-Oriented Research Career Development Award; Muscle; Outcomes Research; Parents; Participant; Patients; Performance; Physical Performance; Pilot Projects; Prospective cohort; Quality of life; Research; Research Training; Risk; Risk Factors; Sepsis; Shapes; Skeletal Muscle; Testing; Thigh structure; Ultrasonography; Woman; Work; acute care; base; cohort; cost; disability; follow-up; functional decline; functional outcomes; grasp; innovation; men; muscle form; muscle strength; physically handicapped; portability; quadriceps muscle; rectus femoris; reduced muscle mass; reduced muscle strength; sarcopenia; standard measure

PROJECT SUMMARY/ABSTRACT Inability to perform Activities of Daily Living (ADLs) is a primary cause of reduced quality of life for the millions of Americans living with AD/ADRD and is an important barrier to living independently for these older Americans. Older adults with AD/ADRD are at particular risk of functional decline and death following hospitalization. Sarcopenia, or aging-related declines in skeletal muscle mass and strength is likely to be an important risk factor for hospital-associated ADL disability in older adults, and this relationship may be particularly relevant in older adults with AD/ADRD. A key barrier to understanding of the contribution of sarcopenia to the development of hospital-associated ADL disability among those with AD/ADRD, is the need for measures of muscle mass that are feasible in these patients in the acute care setting. Bedside portable ultrasound-based measures of thigh muscle architecture are reliable and practical, correlate well with thigh muscle strength in acutely-ill patients, and are already being successfully applied by my group to assess rectus femoris cross-sectional area (RFCSA) in older adults hospitalized with sepsis. This administrative supplement proposal is an extension of the existing K23 grant (5K23AG058756-01; “Sarcopenia as a Predictor of Hospital Associated Disability in Older Adults”), which was awarded to determine the ability of sarcopenia, operationalized as muscle mass and strength, to predict the development of activity of daily living (ADL) disability among hospitalized older adults. The additional studies proposed herein will expand the current research by adding an AD/ADRD focus that will investigate the use of bedside portable ultrasound measures in AD/ADRD patients with sepsis ((n= 25 men (13 with dementia), 25 women (13 with dementia)) with the overall objective of determining relationships of ultrasound-based measures of thigh muscle architecture with functional outcomes of hospitalization in AD/ADRD patients.

项目概要/摘要 无法进行日常生活活动 (ADL) 是数百万人生活质量下降的主要原因 的美国人患有 AD/ADRD，这是这些老年人独立生活的重要障碍 患有 AD/ADRD 的美国人尤其面临功能衰退和死亡的风险。 住院治疗可能是肌肉减少症或与衰老相关的骨骼肌质量和力量下降。 老年人医院相关 ADL 障碍的重要危险因素，这种关系可能是 对于患有 AD/ADRD 的老年人尤其重要，这是理解 AD/ADRD 的贡献的一个关键障碍。 AD/ADRD 患者中肌少症导致医院相关 ADL 障碍的发展是必要的 对于这些患者在床边便携式的情况下可行的肌肉质量测量。 基于超声波的大腿肌肉结构测量可靠且实用，与大腿密切相关 急症患者的肌肉力量，我的小组已经成功地应用于评估直肌 因脓毒症住院的老年人的股骨横截面积 (RFCSA) 本行政补充。 该提案是现有 K23 拨款的延伸（5K23AG058756-01；“肌肉减少症作为医院住院的预测因子”） 老年人的相关残疾”），该奖项旨在确定肌肉减少症的能力， 转化为肌肉质量和力量，以预测日常生活活动 (ADL) 的发展 本文提出的额外研究将扩大目前住院老年人的残疾情况。 研究增加了 AD/ADRD 重点，该重点将调查床边便携式超声测量在 患有脓毒症的 AD/ADRD 患者（n= 25 名男性（13 名患有痴呆），25 名女性（13 名患有痴呆）） 目的是确定基于超声波的大腿肌肉结构测量与 AD/ADRD 患者住院的功能结局。