Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes

Uro-EDICII：1 型糖尿病泌尿系统并发症的风险和进展

• 批准号: 8125097
• 负责人: ARUNA V SARMA
• 金额: $ 50.02万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125097
• 关键词: Affect; Age Factors; Age-Years; Aging; American; Ancillary Study; Androgens; Biological; Biological Markers; Biology; Bladder; Cardiac; Cardiovascular Diseases; Collection; Complex; Complication; Complications of Diabetes Mellitus; Data; Databases; Decreased Libido; Diabetes Mellitus; Disease; Disease Marker; Education; Elderly; Epidemiology; Erectile dysfunction; Family; Female; Frequencies; Functional disorder; Genetic Predisposition to Disease; Genitourinary system; Glycosylated hemoglobin A; Goals; Growth; Health; Healthcare Systems; High Risk Woman; Hypogonadism; Incidence; Insulin-Dependent Diabetes Mellitus; Intervention; Investigation; Kidney Diseases; Magnetic Resonance Imaging; Maps; Measures; Mental Depression; National Institute of Diabetes and Digestive and Kidney Diseases; Neuropathy; Parents; Participant; Patient Self-Report; Patients; Perceived quality of life; Peripheral Nervous System Diseases; Persons; Phenotype; Policy Maker; Population; Prevalence; Preventive Intervention; Prostate; Prostate-Specific Antigen; Prostatic Diseases; Quality of life; Questionnaires; Randomized Controlled Trials; Recruitment Activity; Regulation; Reporting; Retinal Diseases; Risk; Risk Factors; Sampling; Serum; Severities; Sexual Dysfunction; Specimen; Surveys; Symptoms; Testosterone; Time; Time Study; Urinary Incontinence; Vascular Diseases; Weight; Woman; age related; autonomic neuropathy; burden of illness; catalyst; cohort; cost; diabetes control; diabetes mellitus therapy; diabetic; early onset; experience; follow-up; gene environment interaction; genome wide association study; glycemic control; health related quality of life; insight; instrument; interest; intimal medial thickening; lower urinary tract symptoms; meetings; men; multidisciplinary; novel; prevent; public health relevance; research study; response; urologic

DESCRIPTION (provided by applicant): Urinary incontinence, lower urinary tract symptoms and sexual dysfunction are common health problems that reduce quality of life and markedly increase in prevalence and incidence with advancing age. Earlier onset and increased severity of those conditions among men and women with diabetes result in costly and debilitating symptoms. However, data to define incidence, associated factors and interventions to reduce the risk of developing these complications among men and women with type 1 diabetes (T1D) are limited. We have assembled a multidisciplinary team to implement an ancillary study to the Epidemiology of Diabetes Intervention and Complication (EDIC) study, a major ongoing NIDDK research study. The collection of additional survey information from EDIC participants, combined with existing and new biological specimens, will repurpose this important study to measure the new onset of urological symptoms during an important window of time in which the frequency of urological complications is accelerating. Our hypothesis is that urological complications of diabetes impair quality of life (QOL) and that diabetic and systemic factors can be identified that predict men and women at risk for these complications. Our specific aims are to 1) measure the onset and progression of urinary incontinence (UI), lower urinary tract symptom severity (LUTS), and sexual dysfunction (SDF) in men and women with T1D and determine the influence of glycemic therapy and diabetes severity on these complications; 2) determine the influence of low testosterone levels and prostate growth on the associations between glycemic therapy, diabetes severity and the complications of LUTS and SDF in men and 3) measure the impact of the onset and progression of urologic complication on health related QOL I men and women with T1D. The timing of this study is critical in order to capture the upswing in incidence of urological complications as the EDIC cohort reaches 50 years of age. The completion of these aims will provide comprehensive insight into the association between urologic complication and T1D and the impact of these symptoms on QOL. Predictive and protective factors will be identified that map out strategies for intervention and prevention studies. Findings from this proposal may also reveal important relationships between diabetic factors and ageing, bladder and prostate biology, and provide a data repository for biomarker discovery and genome wide association studies. Public Health Relevance: (adapted from the application) The proposed study is likely to offer an opportunity to complete important investigations on urological complications of type 1diabetes by repurposing the DCCT/EDIC parent study and its established cohorts. The collection of additional survey information from recruited study participants is likely to give a one-time chance to capture incident urological complications and the impact of these conditions on quality of life. The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies.

描述（由申请人提供）： 尿失禁，较低的尿路症状和性功能障碍是常见的健康问题，可降低生活质量，并随着年龄的增长而显着增加患病率和发病率。患有糖尿病的男性和女性中这些状况的发作和严重程度的增加导致症状昂贵且使人衰弱。但是，确定发病率的数据，相关因素和干预措施，以减少1型糖尿病（T1D）男性和女性发展这些并发症的风险。我们已经组建了一个多学科团队，以对糖尿病干预和并发症（EDIC）研究的流行病学实施辅助研究，这是一项正在进行的NIDDK研究研究。从EDIC参与者那里收集了其他调查信息，再加上现有和新的生物学标本，将重新利用这项重要的研究，以测量泌尿外识并发症发生频率加速的重要时间窗口中泌尿外科症状的新发作。我们的假设是，糖尿病的泌尿外识并发症会损害生活质量（QOL），并且可以确定糖尿病和全身因素可以预测男人和女性患有这些并发症的风险。我们的具体目的是1）测量患有T1D的男性和女性的尿失禁（UI），较低的尿路症状严重程度（LUTS）和性功能障碍（SDF），并确定血糖疗法和糖尿病严重性的影响； 2）确定低睾丸激素水平和前列腺生长对血糖治疗，糖尿病严重程度与LUTS和SDF的并发症之间关联的影响，以及3）衡量泌尿科并发症对健康相关QOL I与男性和女性的影响。这项研究的时机至关重要，对于随着EDIC队列达到50岁的泌尿科并发症发生率的增长至关重要。这些目的的完成将为泌尿科并发症与T1D之间的关联以及这些症状对QOL的影响提供全面的见解。将确定预测性和保护性因素，以绘制干预和预防研究的策略。该提案的发现还可能揭示糖尿病因素与衰老，膀胱和前列腺生物学之间的重要关系，并为生物标志物发现和基因组广泛关联研究提供了数据存储库。 公共卫生相关性：（（根据应用程序改编）拟议的研究很可能会提供一个机会，通过重新利用DCCT/EDIC父母研究及其既定同类群体来完成对1Diabetes型泌尿外识并发症的重要研究。从招募的研究参与者那里收集了其他调查信息，可能会提供一次机会捕获事件的泌尿科并发症以及这些条件对生活质量的影响。这项研究的确切数据对于教育患者及其家人，有助于发展泌尿外识并发症的生物标志物并为遗传易感性研究提供精炼的表型至关重要。