EFFECTS OF DOPAMINE AND DOPAMINE RECEPTOR POLYMORPHISMS ON EXPERIENCE-DEPENDENT

多巴胺和多巴胺受体多态性对经验依赖性的影响

• 批准号: 8166936
• 负责人: STEVEN Michael CRAMER
• 金额: $ 3.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166936
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Dopamine; Dopamine Receptor; Eligibility Determination; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Grant; Human; Institution; Learning; Levodopa; Marble; Measures; Motor Skills; Patients; Placebos; Randomized; Research; Research Personnel; Research Project Grants; Resources; Source; Time; Transcranial magnetic stimulation; United States National Institutes of Health; behavior measurement; experience; falls; improved; neurophysiology; skills training

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed research project will focus on three different polymorphisms in dopamine-related genes which alter the amount of available CNS dopamine. Subjects will initially be screened for TMS eligibility, and then for these dopamine-related polymorphisms. Subjects falling into the desired genotype groups will be invited to participate further. These subjects will participate in two randomized conditions, one in which the subject receives levodopa prior to motor skill training and one with a placebo. It is hypothesized that neurophysiological and behavioral measures that improve with experience-dependent activity will further improve when examined in the setting of increased CNS dopamine levels; and that this enhancement will vary in relation to dopamine receptor genotype. Studies with animals, healthy humans and patients provide evidence that these genes and polymorphisms are reasonably associated with the cortical plasticity being studied here, and therefore are good candidates for evaluating genetic influences. Dependent variables will be transcranial magnetic stimulation (TMS) measures of cortical plasticity and behavioral measures of learning, as characterized by time to completion and errors on a marble navigation task.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究项目将重点关注与多巴胺相关基因的三种不同多态性，这些多巴胺相关基因改变了可用的中枢神经系统多巴胺的量。 最初将筛选受试者的TMS资格，然后筛选这些与多巴胺相关的多态性。 属于所需的基因型组的受试者将被邀请进一步参与。 这些受试者将参与两个随机条件，其中一个受试者在运动技能训练之前接受左旋多巴，另一个接受安慰剂。假设，在CNS多巴胺水平升高的情况下检查时，随着经验依赖性活动改善的神经生理和行为度量将进一步改善；并且这种增强与多巴胺受体基因型有关。对动物，健康人和患者的研究提供了证据，表明这些基因和多态性与这里研究的皮质可塑性有合理的关系，因此是评估遗传影响的良好候选者。因变量将是经颅磁刺激（TMS）的皮质可塑性和学习行为度量的测量，其特征是完成大理石导航任务的时间和错误。