CLINICAL TRIAL: SAFETY OF REPETITIVE TMS IN CHRONIC SUBCORTICAL STROKE

临床试验：重复 TMS 在慢性皮质下中风中的安全性

• 批准号: 8166905
• 负责人: STEVEN Michael CRAMER
• 金额: $ 0.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166905
• 关键词: Adverse effects; Chronic; Clinical Trials; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Methods; Patients; Physiologic pulse; Protocols documentation; Research; Research Personnel; Resources; Risk; Safety; Source; Stroke; Techniques; United States National Institutes of Health; cohort; experience; medical schools; repetitive transcranial magnetic stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Main introduction: This study will evaluate repetitive transcranial magnetic stimulation (rTMS), which involves delivering TMS pulses faster than with the single pulse TMS methods currently approved at UCI. The technique has a perfect safety record when used as described below, and can have small risks if used at higher settings not considered herein. The current protocol has Dr. Alvaro Pascual-Leone of Harvard Medical School as the sub-PI, who has extensive experience in rTMS. The point is that all aspects of the current study were devised in collaboration with one of the world experts in the method, which should increase confidence in the accuracy of efforts to insure safety. In part 1 of the study, patients at lowest risk of side effects will receive a single rTMS session. If part 1 is found to be safe, part 2 will begin, which will provide a separate cohort of patients with 10 rTMS sessions over 5 weeks. Healthy controls will be studied only with respect to functional MRI (fMRI) methods. Control subjects in the current study will not receive rTMS.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 主要简介：本研究将评估重复的经颅磁刺激（RTMS），该刺激（RTMS）涉及与当前在UCI批准的单个脉冲TMS方法更快地传递TMS脉冲。 如下所述，该技术在使用时具有完美的安全记录，如果在此处未考虑的较高设置处使用，则可能会有很小的风险。 当前的协议将哈佛医学院的Alvaro Pascual-Leone博士作为Sub-Pi，他在RTMS方面拥有丰富的经验。 关键是，当前研究的所有方面都是与该方法的全球专家合作设计的，这应该提高人们对确保安全努力的准确性的信心。 在研究的第1部分中，副作用风险最低的患者将接受一次RTMS会议。 如果发现第1部分是安全的，则第2部分将开始，这将在5周内提供10个RTMS疗程的患者队列。 仅针对功能性MRI（fMRI）方法研究健康对照。 当前研究中的控制对象将无法接收RTM。