PLASMA FFA ELEVATION ON FOREARM BLOOD FLOW AND CAP RECRUITMENT AFTER INSULIN

胰岛素治疗后前臂血流和帽复张的血浆 FFA 升高

• 批准号: 8167152
• 负责人: EUGENE Joseph BARRETT
• 金额: $ 8.15万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167152
• 关键词: Adult; Blood Vessels; Blood capillaries; Blood flow; Computer Retrieval of Information on Scientific Projects Database; Doppler Ultrasound; Dose; Fat emulsion; Fatty Acids; Forearm; Funding; Glucose; Grant; Heparin; Hour; Hypertension; Infusion procedures; Institution; Insulin; Measures; Metabolic; Microbubbles; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Physiological; Plasma; Research; Research Personnel; Resistance; Resources; Skeletal Muscle; Source; Ultrasonography; United States National Institutes of Health; Vasodilation; capillary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent evidence suggests that an insulin infusion at a physiologic dose induces skeletal muscle vasodilation, including the recruitment of new blood vessels. Resistance to insulin's vascular effects after elevation of plasma fatty acids may contribute to the metabolic derangements seen in Type 2 DM, obesity and hypertension. We will study total blood flow, capillary recruitment in the forearm, and whole body glucose utilization of 22 lean healthy adults at baseline and after a two hour euglycemic insulin clamp on two separate occasions. With one clamp, we will infuse "Intralipid" and heparin creating a fatty acid elevation, and the other clamp will be conducted without the "Intralipid"/heparin infusion, as a control. We will measure the blood flow and capillary recruitment using Doppler Ultrasound and CEU (microbubble contrast-enhanced ultrasound).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 最近的证据表明，生理剂量的胰岛素输注会诱导骨骼肌血管舒张，包括募集新血管。血浆脂肪酸升高后对胰岛素血管作用的耐药性可能导致2型DM，肥胖和高血压中看到的代谢危险。 我们将研究总血流，前臂中的毛细血管募集以及基线时22名健康成年人的全身葡萄糖利用，以及在两次单独的两种情况下进行了两个小时的尤基兰血糖胰岛素夹。 使用一个夹具，我们将注入“脂质内”和肝素产生脂肪酸抬高，而将进行另一个夹具，而无需进行“内脂肪内”/肝素输注作为对照。 我们将使用多普勒超声和CEU（微气泡对比度增强超声）测量血流和毛细管募集。