EXERCISE INTENSITY AND POST-PRANDIAL GLUCOSE DISPOSAL IN OBESE ADULTS

肥胖成人的运动强度和餐后血糖处理

• 批准号: 8167178
• 负责人: EUGENE Joseph BARRETT
• 金额: $ 1.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167178
• 关键词: Adult; Area Under Curve; Atherosclerosis; Biological Assay; Blood; Blood specimen; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Dose; Exercise; Expenditure; Funding; Glucose; Grant; Individual; Institution; Insulin; Insulin Resistance; Measures; Modeling; Myocardial Infarction; Obesity; Output; Peptides; Protocols documentation; Randomized; Research; Research Personnel; Resources; Rest; Risk; Source; Stroke; Testing; Time; United States National Institutes of Health; Woman; glucose disposal; impaired glucose tolerance; insulin sensitivity; men; response; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In individuals with impaired glucose tolerance, exacerbated post-prandial glycemic excursions occur with higher levels of both glucose and insulin in the blood for longer periods of time. Increasing evidence suggests that these exacerbated post-prandial excursions are closely associated with, and may be pre-disposing for, many of the complications associated with diabetes and insulin resistance, including atherosclerosis, myocardial infarction, and stroke. Exercise has been shown to reduce the risks associated with insulin resistance and is an effective means of reducing glycemic excursions and increasing insulin sensitivity. In the present study, we will examine the dose-response relationship between intensity of exercise at equal caloric output and the resultant glycemic effects, with the ultimate aim of identifying the minimum effective exercise intensity for the reduction of post-prandial glycemic excursions. Abdominally obese subjects (BMI > 30, waist circumference > 80 cm for women and > 94 cm for men) will be tested on the GCRC on 5 occasions: (1) - a baseline VO2 Peak / LT protocol to determine exercise intensities and (4) randomly assigned sessions at rest and at 3 differing exercise intensities (low, moderate, intense - exercise duration will vary so that caloric expenditure can be constant for each exercise session at 250 kcal). During tests 2-5, seventy five grams of glucose will be administered 1 h after the onset of exercise. Blood samples will be collected at -30, -20 -10, 0, and at 5-10 minute intervals after the onset of exercise for 240 min and assayed for glucose, insulin and c-peptide. Glucose and insulin rate of change and area under the curve will be calculated. Minimal modeling will be used to assess glucose disposal and insulin sensitivity, and c-peptide minimal model will be used to evaluate -cell function. Repeated measures ANCOVA with covariate SI will be used to examine differences among conditions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在葡萄糖耐量受损的个体中，长时间血液中葡萄糖和胰岛素的较高水平的后，后帕血糖的恶化。越来越多的证据表明，这些加剧的餐后偏移与许多与糖尿病和胰岛素抵抗有关的并发症（包括动脉粥样硬化，心肌梗塞和中风）密切相关，并且可能是预先分配的。运动已被证明可以降低与胰岛素抵抗相关的风险，并且是减少血糖偏移和提高胰岛素敏感性的有效手段。在本研究中，我们将研究均等热量输出的运动强度与由此产生的血糖作用之间的剂量反应关系，最终目的是确定最低有效的运动强度，以减少餐后血糖的偏离。腹部肥胖受试者（BMI> 30，女性的腰围> 80 cm，男性> 94 cm）将在GCRC上进行5次测试：（1） - 一种基线VO2峰 / LT协议，以确定运动强度，以确定运动强度，（4）在静止和锻炼中的静止，持续的练习均为耐心，以至于持续的效率，以至于持续不断的锻炼，以至于均等，以至于持续时间持续效果，以至于持续时间持续时间，以至于持续时间持续效果，以至于持续时间持续时间 - 250 kcal的练习。在2-5测试期间，运动开始后1小时将进行75克葡萄糖。血液样本将在-30，-20 -10、0中收集，并在运动发作后的5-10分钟间隔240分钟，并测定葡萄糖，胰岛素和C肽。将计算葡萄糖和胰岛素的变化速率和曲线下的面积。最小的建模将用于评估葡萄糖处置和胰岛素敏感性，并且C肽最小模型将用于评估细胞功能。与协变量SI的ANCOVA重复测量将用于检查条件之间的差异。