DIFFUSION TENSOR IMAGING IN FIRST EPISODE SCHIZOPHRENIA

首发精神分裂症的弥散张量成像

• 批准号: 8167222
• 负责人: PHILIP R SZESZKO
• 金额: $ 4.2万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167222
• 关键词: Antipsychotic Agents; Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Diffusion Magnetic Resonance Imaging; Funding; Future; Grant; Institution; Measures; National Institute of Mental Health; Patients; Pharmaceutical Preparations; Pilot Projects; Research; Research Personnel; Resources; Role; Schizophrenia; Source; Temporal Lobe; United States National Institutes of Health; experience; first episode schizophrenia; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Little description has been directed at understanding the role of white matter microstructural abnormalities in schizophrenia prior to treatment with antipsychotic agents and the potential effects of these medications on measures of white matter integrity. In this pilot study, we plan to investigate white matter abnormalities, using diffusion tensor imaging (DTI), in patients experiencing a first-episode of schizophrenia at the onset of treatment and then following 12 weeks of standarized treatment. It is hypothesized that patients will demonstrate white matter abnormalities in the frontal and temporal lobes at the baseline and that increases in white matter integrity will occur in these regions following antipsychotic treatment. This data will be used to demonstrate feasibility of collection of longitudinal DTI data for a future grant submission to the NIMH.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在用抗精神病药治疗之前，几乎没有描述白质微结构异常在精神分裂症中的作用，以及这些药物对白质完整性测量的潜在影响。在这项试点研究中，我们计划使用扩散张量成像（DTI）调查白质异常，该患者在治疗开始时经历了精神分裂症的第一集，然后在预定的治疗中进行了12周后。假设患者将在基线处表现出额叶和颞叶的白质异常，并且在抗精神病药物治疗后，这些区域将发生白质完整性的增加。该数据将用于证明收集纵向DTI数据的可行性，以提交给NIMH的未来赠款。