NEUROIMAGING STUDIES OF FRONTAL LOBE PATHOLOGY IN OCD

强迫症额叶病理学的神经影像学研究

• 批准号: 7955798
• 负责人: PHILIP R SZESZKO
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955798
• 关键词: Computer Retrieval of Information on Scientific Projects Database; DSM-IV; Data; Diagnosis; Disease model; Functional disorder; Funding; Grant; Individual; Institution; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measures; Methods; Modeling; Neurobiology; Obsessive-Compulsive Disorder; Pathology; Patients; Prefrontal Cortex; Research; Research Personnel; Resources; Rest; Role; Slice; Source; Structure; Surface; Symptoms; Thick; United States National Institutes of Health; Weight; computational anatomy; density; frontal lobe; gray matter; healthy volunteer; neuroimaging; neuropsychological; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Few magnetic resonance (MR) studies have investigated possible structural alterations of the prefrontal cortex in individuals with obsessive-compulsive disorder (OCD) despite the importance of this region to neurobiologic models of the disorder. Assessment of frontal subregions in OCD is potentially important because it is known that the frontal lobes are both structurally and functionally heterogeneous. In this study we will use methods for cortical surface mapping to investigate the orbital frontal cortex, which has been implicated in the pathophysiology of OCD from functional neuroimaging studies. Twenty-five patients with a DSM-IV diagnosis of OCD and matched healthy volunteers will receive MR imaging scans consisting of 124 contiguous T1-weighted coronal SPGR MR images (slice thickness = 1.5mm). It is hypothesized that compared to healthy volunteers, patients will demonstrate increased grey matter density in the orbital frontal region consistent with functional neuroimaging studies demonstrating hypermetabolism of this region during rest conditions and symptom provocation. Increased grey matter density will be associated with worse neuropsychological functioning on measures of response inhibition. It is expected that these data will yield important information regarding the potential role of frontal cortical abnormalities in the neurobiology of OCD as well as abnormal structure-function relations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尽管该区域对该疾病的神经生物学模型的重要性，但很少很少有磁共振（MR）研究研究了强迫症（OCD）患者的前额叶皮层的可能结构改变。 OCD中额叶区域的评估可能很重要，因为众所周知，额叶在结构和功能上都是异质的。 在这项研究中，我们将使用方法进行皮质表面映射来研究轨道额叶皮层，该皮质与功能性神经成像研究有关OCD的病理生理学。 25例DSM-IV诊断强迫症和匹配的健康志愿者的患者将接受MR成像扫描，包括124个连续的T1加权冠状SPGR MR图像（切片厚度= 1.5mm）。假设与健康的志愿者相比，患者将证明轨道额叶区域的灰质密度增加，这与功能性神经成像研究一致，这些研究表明在休息条件和症状挑衅下该区域的超级实施代谢。 灰质密度的增加将与较差的神经心理学功能有关，在反应抑制度量方面。 预计这些数据将产生有关额叶皮质异常在OCD神经生物学以及异常结构 - 功能关系中的潜在作用的重要信息。