Methyl Mercury Effect on Adolescent Development Renewal

甲基汞对青少年发育更新的影响

基本信息

批准号：
8144850
负责人：
PHILIP W DAVIDSON
金额：
$ 74.1万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8144850
关键词：
21 year old Adolescence Adolescent Development Adult Adverse effects Affect Age-Years Anti-Inflammatory Agents Anti-inflammatory Atherosclerosis Attention Attenuated Behavioral Benefits and Risks Biological Markers Blood Pressure Brain C-reactive protein Cardiac Cardiovascular system Child Development Cognition Cognitive Cohort Studies Complex Consumption Coupled Data Development Diet Discrimination Learning Eating Evaluation Exposure to Fishes Funding Grant Health Heart Homeostasis Hypertension Impaired cognition Impairment Impulsivity Inflammation Ion Channel Lead Life Literature Longevity Mammals Measurement Measures Medial Mercury Modification Morbidity - disease rate Mothers Myocardium National Research Council Neuraxis Neurocognition Neurocognitive Nutrient Nutritional status Organ Outcome Pattern Polychlorinated Biphenyls Polyunsaturated Fatty Acids Population Pregnancy Psychomotor Performance Public Health Regulation Reporting Research Resources Risk Risk Factors Scientist Sea Sentinel Seychelles Social Behavior Staging Study Subject Testing Thick Time Tissues Toxic effect Universities Vascular Endothelium arterial stiffness blood pressure regulation cognitive function cohort emerging adult exposed human population fetal follow-up heart function heart rate variability improved indexing innovation insight lead exposure member model design neurocognitive test postnatal prenatal prenatal exposure prenatal influence programs public health relevance relating to nervous system response stem toxicant young adult

项目摘要

DESCRIPTION (provided by applicant): This application is a competing renewal of Grant 5-R01ES008442 entitled "Methyl Mercury Effects on Adolescent Development." The Seychelles Child development Study (SCDS) has been testing the hypothesis that methyl mercury (MeHg) exposure from consumption of a diet high in fish is associated with adverse health outcomes. Exposure to MeHg from fish consumption is thought to impair cognition and neuro-regulation of the heart. Since 1989, we have been following a cohort of 779 subjects born to mothers who consumed an average of 12 fish-meals per week during pregnancy. The subjects are now approaching 21 years of age. The subjects have been assessed for cognitive and behavioral development. In 2006, the project was expanded with funds from a competing supplement to include measurements of autonomic heart regulation. The subjects themselves habitually consume a diet high in fish. Fish contain both MeHg and nutrients including long-chain polyunsaturated fatty acids (LCPUFA) which are beneficial to brain development and heart function. Preliminary data suggest that prenatal and postnatal exposures to combined MeHg and LCPUFA in fish may be associated with distinct patterns of results. Limited information is available on postnatal exposures however. We will examine the SCDS cohort at approximately 21 and 23 years of age to assess the net cumulative risk of exposure to postnatal MeHg and recent LCPUFA status on cognitive outcomes and cardiovascular parameters. Statistical analyses will employ innovative parametric and non-parametric modeling designed to ascertain the effects on these endpoints of co-exposures to postnatal, adjusted for prenatal MeHg exposure, and/or lifetime cumulative (prenatal and postnatal) exposure to MeHg, and recent exposure to LCPUFA to ascertain the separate risks attendant to these exposures. The Seychelles population has many similarities with that of the US and can therefore serve as a sentinel for the risks and benefits of fish consumption. The low loss to follow-up provides a unique opportunity to continue to study this very well characterized cohort and differentiate prenatal from postnatal MeHg effects as its members move from adolescence to young adult life. The findings from this study will be important as governmental agencies continue to evaluate the scientific data regarding toxic effects and nutrient benefits of a high fish diet. The study should also clarify the risks and benefits of fish consumption in relation to neurocognitive and cardiac morbidity that may not become clinically manifest until later in adulthood. PUBLIC HEALTH RELEVANCE: Human exposure to MeHg is almost exclusively from fish consumption and all fish contain some MeHg. But fish also provide other highly beneficial nutrients, such as long chain polyunsaturated fatty acids (LCPUFA) that are essential for development and function of the central nervous system (CNS) and appear to mitigate some effects of prenatal mercury exposure. Findings during the past funding period demonstrate beneficial effects of prenatal MeHg, but adverse effects of postnatal MeHg on different neurocognitive and behavioral functions, and a beneficial impact on neuro-regulation of the heart, demonstrating differential net risks or benefits for these functions that are time and organ-dependent and which therefore may require different public health risk considerations and revisions of documents, such as the National Research Council Report (2002). The proposed study makes innovative use of our well-characterized cohort to determine for the first time whether LCPUFA, that actually have a continuing influence on the CNS across the life span, interact with lifetime and recent postnatal MeHg exposure to modulate its influence on neurocognition and cardiac functions. The results should have immediate and important public health implications for agencies that advise the public about fish consumption. If LCPUFA do not interact with postnatal MeHg exposure, as they do with prenatal MeHg exposure, our findings will suggest that public health risks associated with the two exposures may be different and would have to be differentially considered.

描述（由申请人提供）：本申请是题为“甲基汞对青少年发育的影响”的 5-R01ES008442 号拨款的竞争性续展。塞舌尔儿童发育研究 (SCDS) 一直在测试这样的假设：食用富含鱼类的饮食而接触甲基汞 (MeHg) 与不良健康结果相关。人们认为，食用鱼类而接触甲基汞会损害认知和心脏的神经调节。自 1989 年以来，我们一直在追踪 779 名受试者，这些受试者的母亲在怀孕期间平均每周食用 12 顿鱼粉。受试者现在已接近 21 岁。对受试者的认知和行为发展进行了评估。 2006 年，该项目得到了来自竞争补充品的资金的扩展，将自主心脏调节的测量纳入其中。受试者本身习惯性地食用富含鱼类的饮食。鱼含有甲基汞和长链多不饱和脂肪酸（LCPUFA）等营养物质，有利于大脑发育和心脏功能。初步数据表明，鱼类产前和产后接触甲基汞和长链不饱和脂肪酸可能与不同的结果模式相关。然而，有关产后暴露的信息有限。我们将检查大约 21 岁和 23 岁的 SCDS 队列，以评估出生后接触 MeHg 的净累积风险以及认知结果和心血管参数的近期 LCPUFA 状态。统计分析将采用创新的参数和非参数模型，旨在确定产后共同暴露对这些终点的影响，并根据产前甲基汞暴露和/或终生累积（产前和产后）甲基汞暴露以及近期接触甲基汞进行调整。 LCPUFA 以确定与这些暴露相关的单独风险。塞舌尔人口与美国人口有许多相似之处，因此可以作为鱼类消费风险和收益的哨兵。低失访率提供了一个独特的机会，可以继续研究这一特征明确的队列，并区分其成员从青春期过渡到成年后的产前和产后甲基汞效应。这项研究的结果非常重要，因为政府机构将继续评估有关高鱼饮食的毒性作用和营养益处的科学数据。该研究还应阐明食用鱼类与神经认知和心脏疾病相关的风险和益处，这些疾病可能要到成年后期才会在临床上显现出来。公共卫生相关性：人类接触甲基汞几乎完全来自鱼类消费，所有鱼类都含有一定程度的甲基汞。但鱼还提供其他非常有益的营养物质，例如长链多不饱和脂肪酸 (LCPUFA)，它对于中枢神经系统 (CNS) 的发育和功能至关重要，并且似乎可以减轻产前汞暴露的一些影响。过去资助期间的研究结果表明，产前甲基汞对不同的神经认知和行为功能有有益影响，但产后甲基汞对不同的神经认知和行为功能产生不利影响，并对心脏的神经调节产生有益影响，表明这些功能的净风险或益处随时间的推移而有所不同。和器官依赖性，因此可能需要不同的公共卫生风险考虑和文件修订，例如国家研究委员会报告（2002）。拟议的研究创新性地利用了我们充分表征的队列，首次确定 LCPUFA（实际上对整个生命周期中的 CNS 有持续影响）是否与一生和最近出生后的 MeHg 暴露相互作用，以调节其对神经认知和神经认知的影响。心脏功能。研究结果对于向公众提供鱼类消费建议的机构来说应该具有直接且重要的公共卫生影响。如果 LCPUFA 不会像与产前甲基汞暴露一样与产后甲基汞暴露相互作用，那么我们的研究结果将表明，与两种暴露相关的公共卫生风险可能不同，必须区别对待。