Methyl Mercury Effect on Adolescent Development Renewal

甲基汞对青少年发育更新的影响

• 批准号: 8144850
• 负责人: PHILIP W DAVIDSON
• 金额: $ 74.1万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8144850
• 关键词: 21 year old; Adolescence; Adolescent Development; Adult; Adverse effects; Affect; Age-Years; Anti-Inflammatory Agents; Anti-inflammatory; Atherosclerosis; Attention; Attenuated; Behavioral; Benefits and Risks; Biological Markers; Blood Pressure; Brain; C-reactive protein; Cardiac; Cardiovascular system; Child Development; Cognition; Cognitive; Cohort Studies; Complex; Consumption; Coupled; Data; Development; Diet; Discrimination Learning; Eating; Evaluation; Exposure to; Fishes; Funding; Grant; Health; Heart; Homeostasis; Hypertension; Impaired cognition; Impairment; Impulsivity; Inflammation; Ion Channel; Lead; Life; Literature; Longevity; Mammals; Measurement; Measures; Medial; Mercury; Modification; Morbidity - disease rate; Mothers; Myocardium; National Research Council; Neuraxis; Neurocognition; Neurocognitive; Nutrient; Nutritional status; Organ; Outcome; Pattern; Polychlorinated Biphenyls; Polyunsaturated Fatty Acids; Population; Pregnancy; Psychomotor Performance; Public Health; Regulation; Reporting; Research; Resources; Risk; Risk Factors; Scientist; Sea; Sentinel; Seychelles; Social Behavior; Staging; Study Subject; Testing; Thick; Time; Tissues; Toxic effect; Universities; Vascular Endothelium; arterial stiffness; blood pressure regulation; cognitive function; cohort; emerging adult; exposed human population; fetal; follow-up; heart function; heart rate variability; improved; indexing; innovation; insight; lead exposure; member; model design; neurocognitive test; postnatal; prenatal; prenatal exposure; prenatal influence; programs; public health relevance; relating to nervous system; response; stem; toxicant; young adult

DESCRIPTION (provided by applicant): This application is a competing renewal of Grant 5-R01ES008442 entitled "Methyl Mercury Effects on Adolescent Development." The Seychelles Child development Study (SCDS) has been testing the hypothesis that methyl mercury (MeHg) exposure from consumption of a diet high in fish is associated with adverse health outcomes. Exposure to MeHg from fish consumption is thought to impair cognition and neuro-regulation of the heart. Since 1989, we have been following a cohort of 779 subjects born to mothers who consumed an average of 12 fish-meals per week during pregnancy. The subjects are now approaching 21 years of age. The subjects have been assessed for cognitive and behavioral development. In 2006, the project was expanded with funds from a competing supplement to include measurements of autonomic heart regulation. The subjects themselves habitually consume a diet high in fish. Fish contain both MeHg and nutrients including long-chain polyunsaturated fatty acids (LCPUFA) which are beneficial to brain development and heart function. Preliminary data suggest that prenatal and postnatal exposures to combined MeHg and LCPUFA in fish may be associated with distinct patterns of results. Limited information is available on postnatal exposures however. We will examine the SCDS cohort at approximately 21 and 23 years of age to assess the net cumulative risk of exposure to postnatal MeHg and recent LCPUFA status on cognitive outcomes and cardiovascular parameters. Statistical analyses will employ innovative parametric and non-parametric modeling designed to ascertain the effects on these endpoints of co-exposures to postnatal, adjusted for prenatal MeHg exposure, and/or lifetime cumulative (prenatal and postnatal) exposure to MeHg, and recent exposure to LCPUFA to ascertain the separate risks attendant to these exposures. The Seychelles population has many similarities with that of the US and can therefore serve as a sentinel for the risks and benefits of fish consumption. The low loss to follow-up provides a unique opportunity to continue to study this very well characterized cohort and differentiate prenatal from postnatal MeHg effects as its members move from adolescence to young adult life. The findings from this study will be important as governmental agencies continue to evaluate the scientific data regarding toxic effects and nutrient benefits of a high fish diet. The study should also clarify the risks and benefits of fish consumption in relation to neurocognitive and cardiac morbidity that may not become clinically manifest until later in adulthood. PUBLIC HEALTH RELEVANCE: Human exposure to MeHg is almost exclusively from fish consumption and all fish contain some MeHg. But fish also provide other highly beneficial nutrients, such as long chain polyunsaturated fatty acids (LCPUFA) that are essential for development and function of the central nervous system (CNS) and appear to mitigate some effects of prenatal mercury exposure. Findings during the past funding period demonstrate beneficial effects of prenatal MeHg, but adverse effects of postnatal MeHg on different neurocognitive and behavioral functions, and a beneficial impact on neuro-regulation of the heart, demonstrating differential net risks or benefits for these functions that are time and organ-dependent and which therefore may require different public health risk considerations and revisions of documents, such as the National Research Council Report (2002). The proposed study makes innovative use of our well-characterized cohort to determine for the first time whether LCPUFA, that actually have a continuing influence on the CNS across the life span, interact with lifetime and recent postnatal MeHg exposure to modulate its influence on neurocognition and cardiac functions. The results should have immediate and important public health implications for agencies that advise the public about fish consumption. If LCPUFA do not interact with postnatal MeHg exposure, as they do with prenatal MeHg exposure, our findings will suggest that public health risks associated with the two exposures may be different and would have to be differentially considered.

描述（由申请人提供）：此申请是授予5-R01ES008442的竞争续约，标题为“甲基汞对青少年发展的影响”。塞舌尔儿童发展研究（SCDS）一直在测试以下假设：甲基汞（MEHG）从饮食中的饮食含量较高，与不良的健康结果有关。人们认为，从鱼类食用中接触MEHG会损害心脏的认知和神经调节。自1989年以来，我们一直在遵循779名母亲所生的779名受试者，他们在怀孕期间平均每周食用12种鱼类麦克。受试者现在正接近21岁。对受试者的认知和行为发展进行了评估。 2006年，该项目通过竞争补充剂的资金扩展，包括对自主心脏调节的测量。受试者本身习惯性地消耗鱼类饮食。 FISH含有MEHG和营养素，包括有益于大脑发育和心脏功能的长链多不饱和脂肪酸（LCPUFA）。初步数据表明，鱼类中对MEHG和LCPUFA组合的产后和产后暴露可能与不同的结果模式有关。但是，有关产后暴露的信息有限。我们将在大约21岁和23岁时检查SCDS队列，以评估承担产后MEHG的净累积风险以及最近在认知结果和心血管参数的LCPUFA状态。统计分析将采用创新的参数和非参数建模，旨在确定对这些共同曝光的终点的影响，以调整了产前MEHG暴露，以及/或终身累积累积（产后和产后和后期）暴露于MEHG，以及最近对LCPUFA的验证危险，以使其与lcpufa的相同风险相同。塞舌尔人的人口与美国的相似之处许多相似之处，因此可以作为哨兵的鱼类消费风险和益处。低损失的后续行动为继续研究这种表征良好的队列并将产前与产后MEHG效应区分开来提供了一个独特的机会，因为其成员从青春期转变为年轻人生活。随着政府机构继续评估有关高鱼类饮食的毒性作用和营养益处的科学数据，这项研究的发现将很重要。这项研究还应阐明与神经认知和心脏发病率有关的鱼类消耗的风险和益处，直到成年后期才可能在临床上显现出来。 公共卫生相关性：人类对MEHG的接触几乎完全来自鱼类食用，所有鱼都含有一些MEHG。但是FISH还提供其他高度有益的营养素，例如对于中枢神经系统（CNS）的发育和功能至关重要的长链多不饱和脂肪酸（LCPUFA），并且似乎减轻了产前汞暴露的某些影响。在过去的资金期间的发现表明了产前MEHG的有益影响，但产后MEHG对不同的神经认知和行为功能的不利影响，以及对心脏神经调节的有益影响，表明对这些功能的差异净风险或益处对这些功能和机器人的依赖于哪些是依赖于时间和机构的，因此需要报告公共健康的委员会，并报告了不同的保健风险考虑，并在2002年的情况下进行了2002年的研究（均为2002年）。拟议的研究使我们的特征良好的队列创新使用，以首次确定LCPUFA是否对整个寿命中的CNS有持续的影响，与寿命相互作用以及最近产后MEHG暴露以调节其对神经认知和心脏功能的影响。结果应该对向公众提供有关鱼类消费的机构有直接而重要的公共卫生影响。如果LCPUFA与产后MEHG的暴露不相互作用，就像与产前MEHG暴露一样，我们的发现将表明，与这两种暴露相关的公共卫生风险可能有所不同，并且必须差异化。