Autism in a Fish Eating Population

吃鱼人群中的自闭症

• 批准号: 7371269
• 负责人: PHILIP W DAVIDSON
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7371269
• 关键词: Address; Adolescent; Adolescent Development; Autacoids; Autistic Disorder; Behavior; Biological Assay; Child; Child Development; Cohort Studies; Consumption; Data; Diagnosis; Diagnostic; Diagnostic Procedure; Diet; Eating; Exposure to; Fishes; Funding; Future; Gold; Grant; Hair; Human Resources; Link; Measures; Mercury; Merthiolate; Methylmercury Compounds; Outcome; Parents; Phenotype; Policy Maker; Population; Pregnancy; Prevalence; Public Health; Publishing; Questionnaires; Rate; Reporting; Research; Rice; Risk; Sampling; Scientist; Score; Screening procedure; Seychelles; Sodium; Staging; Standards of Weights and Measures; Surveys; Symptoms; Testing; Thimerosal; Thinking; Time; United States; Withdrawal; Work; autism spectrum disorder; cohort; cost; design; human study; instrument; methylmercury exposure; postnatal; prenatal; prenatal exposure; social; social communication; social reciprocity; teacher

DESCRIPTION (provided by applicant): This proposal is for a two-year project that expands the Seychelles Child Development Study a longitudinal cohort study following children and adolescents in the Republic of Seychelles who were exposed prenatally to MeHg through maternal consumption of a diet high in fish. It provides a unique opportunity to examine the controversial issue of whether ASD is related to MeHg exposure-an issue that has major public health implications in the United States. Recent pilot data from 445 adolescents participating in the SCDS suggested an adverse association between scores on the Social Reciprocity Scale (a teacher questionnaire used to screen for ASD symptoms) and prenatal MeHg exposure. The expected prevalence of ASD is 1:166, hence a very large cohort would be necessary to compare rates in the Seychelles and elsewhere. There are three adolescent cohorts available for study. The first, called the Main Cohort is being examined currently with funding from Grant 2-R01ES08442-05. The proposed project would expand the assessment of this cohort to include administration of the Social Communication Questionnaire (SCQ) a parental screening for ASD. The current assessment battery does not include measures of ASD. We would also screen parents of children from the two other cohorts using the SCQ (called the Pilot Cohort and the Third Cohort) who have not been examined in order to increase statistical power to detect ASD. The prenatal exposure to MeHg is known already for the Main Cohort (N=739) and Pilot Cohort (N=789) subjects. We expect to recall an additional 3,150 parents of Third Cohort children whose maternal hair samples have not yet been analyzed for Hg. The proposed project would permit expansion of the subject pool with known prenatal MeHg exposure to approximately 4,678 subjects. At the conclusion of the proposed project, we will estimate the association between prenatal MeHg exposure and SCQ scores. If warranted by the outcome, this newly characterized cohort could then be used for further study using standard diagnostic procedures to clarify the association between MeHg and ASD and to determine the prevalence of ASD in a population with known high exposure to MeHg from fish consumption during pregnancy. Public Health Significance Concern is growing among scientists and policy makers that there may be a link between exposure to methylmercury and ASD phenotype. There are no published human studies where prenatal exposure to methylmercury has been ascertained and offspring have been tested for ASD. The Seychelles Child Development Study provides a rare opportunity to test the hypothesis that there is an association between ASD and methylmercury exposure from fish consumption.

说明（由申请人提供）：本提案针对一个为期两年的项目，该项目扩展了塞舌尔儿童发展研究，这是一项纵向队列研究，针对塞舌尔共和国的儿童和青少年，这些儿童和青少年在产前因母亲摄入高甲基汞的饮食而暴露于甲基汞。鱼。它提供了一个独特的机会来研究自闭症谱系障碍是否与甲基汞暴露有关这一有争议的问题，这一问题在美国具有重大的公共卫生影响。最近参与 SCDS 的 445 名青少年的试点数据表明，社会互惠量表（用于筛查 ASD 症状的教师问卷）得分与产前甲基汞暴露之间存在负相关。 ASD 的预期患病率为 1:166，因此需要一个非常大的队列来比较塞舌尔和其他地方的患病率。有三个青少年队列可供研究。第一个称为“主要队列”，目前正在接受 2-R01ES08442-05 拨款资助的审查。拟议的项目将扩大对这一群体的评估，包括社会沟通问卷（SCQ）的管理和家长对自闭症谱系障碍（ASD）的筛查。当前的评估组合不包括自闭症谱系障碍（ASD）的测量。我们还将使用 SCQ 对其他两个队列（称为试点队列和第三队列）中尚未接受检查的儿童的父母进行筛查，以提高检测自闭症谱系障碍的统计能力。主要队列 (N=739) 和试点队列 (N=789) 受试者的产前甲基汞暴露情况已为人所知。我们预计将召回另外 3,150 名第三队列儿童的父母，他们的母亲头发样本尚未进行汞分析。拟议的项目将允许将已知产前甲基汞暴露的受试者库扩大到约 4,678 名受试者。在拟议项目结束时，我们将估计产前甲基汞暴露与 SCQ 评分之间的关​​联。如果结果证实，这个新表征的队列可以用于使用标准诊断程序进行进一步研究，以澄清甲基汞和自闭症谱系障碍之间的关联，并确定已知在怀孕期间因食用鱼类而大量接触甲基汞的人群中自闭症谱系障碍的患病率。公共卫生意义 科学家和政策制定者越来越担心接触甲基汞和自闭症谱系障碍表型之间可能存在联系。目前尚无已发表的人体研究确定产前甲基汞暴露情况，也没有对后代进行自闭症谱系障碍测试。塞舌尔儿童发展研究提供了一个难得的机会来检验自闭症谱系障碍与鱼类消费中甲基汞暴露之间存在关联的假设。