Autism in a Fish Eating Population

吃鱼人群中的自闭症

• 批准号: 7557846
• 负责人: PHILIP W DAVIDSON
• 金额: $ 17.25万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7557846
• 关键词: Address; Adolescent; Adolescent Development; Autacoids; Autistic Disorder; Behavior; Biological Assay; Child; Child Development; Cohort Studies; Consumption; Data; Diagnosis; Diagnostic; Diagnostic Procedure; Diet; Eating; Exposure to; Fishes; Funding; Future; Gold; Grant; Hair; Human; Human Resources; Link; Measures; Mercury; Merthiolate; Methylmercury Compounds; Outcome; Parents; Phenotype; Policy Maker; Population; Pregnancy; Prevalence; Public Health; Publishing; Questionnaires; Reporting; Research; Rice; Risk; Sampling; Scientist; Screening procedure; Seychelles; Sodium; Staging; Surveys; Symptoms; Testing; Thimerosal; Time; United States; Withdrawal; Work; autism spectrum disorder; cohort; cost; design; instrument; methylmercury exposure; offspring; postnatal; prenatal; prenatal exposure; social; social communication; social reciprocity; teacher

DESCRIPTION (provided by applicant): This proposal is for a two-year project that expands the Seychelles Child Development Study a longitudinal cohort study following children and adolescents in the Republic of Seychelles who were exposed prenatally to MeHg through maternal consumption of a diet high in fish. It provides a unique opportunity to examine the controversial issue of whether ASD is related to MeHg exposure-an issue that has major public health implications in the United States. Recent pilot data from 445 adolescents participating in the SCDS suggested an adverse association between scores on the Social Reciprocity Scale (a teacher questionnaire used to screen for ASD symptoms) and prenatal MeHg exposure. The expected prevalence of ASD is 1:166, hence a very large cohort would be necessary to compare rates in the Seychelles and elsewhere. There are three adolescent cohorts available for study. The first, called the Main Cohort is being examined currently with funding from Grant 2-R01ES08442-05. The proposed project would expand the assessment of this cohort to include administration of the Social Communication Questionnaire (SCQ) a parental screening for ASD. The current assessment battery does not include measures of ASD. We would also screen parents of children from the two other cohorts using the SCQ (called the Pilot Cohort and the Third Cohort) who have not been examined in order to increase statistical power to detect ASD. The prenatal exposure to MeHg is known already for the Main Cohort (N=739) and Pilot Cohort (N=789) subjects. We expect to recall an additional 3,150 parents of Third Cohort children whose maternal hair samples have not yet been analyzed for Hg. The proposed project would permit expansion of the subject pool with known prenatal MeHg exposure to approximately 4,678 subjects. At the conclusion of the proposed project, we will estimate the association between prenatal MeHg exposure and SCQ scores. If warranted by the outcome, this newly characterized cohort could then be used for further study using standard diagnostic procedures to clarify the association between MeHg and ASD and to determine the prevalence of ASD in a population with known high exposure to MeHg from fish consumption during pregnancy. Public Health Significance Concern is growing among scientists and policy makers that there may be a link between exposure to methylmercury and ASD phenotype. There are no published human studies where prenatal exposure to methylmercury has been ascertained and offspring have been tested for ASD. The Seychelles Child Development Study provides a rare opportunity to test the hypothesis that there is an association between ASD and methylmercury exposure from fish consumption.

描述（由申请人提供）：该提案是针对为期两年的项目，该项目扩大了塞舌尔儿童发展研究研究，一项纵向队列研究是在塞舌尔共和国共和国的儿童和青少年，他们通过高饮食中的饮食饮食中的饮食中的饮食中的饮食量高。它提供了一个独特的机会来研究ASD是否与MEHG暴露有关的有争议的问题 - 在美国具有重大公共卫生影响的问题。来自SCD的445名青少年的最新试验数据表明，社会互惠量表的分数（用于筛查ASD症状的教师问卷）和产前MEHG暴露之间存在不利的关联。 ASD的预期患病率为1：166，因此需要一个非常大的队列才能比较塞舌尔和其他地方的率。有三个青春期队列可供研究。第一个称为主要队列的人正在通过赠款2-R01ES08442-05的资金进行检查。拟议的项目将扩大对该队列的评估，以包括对社会传播问卷（SCQ）进行ASD的父母筛查。当前的评估电池不包括ASD的措施。我们还将使用SCQ（称为飞行员队列和第三个队列）从其他两个同类群体中筛选孩子的父母，他们尚未接受检查以增加检测ASD的统计能力。产前接触MEHG已经以主要队列（n = 739）和飞行员队列（n = 789）受试者而闻名。我们预计将回想起另外3,150名第三个队列孩子的父母，他们的母亲头发样本尚未分析Hg。拟议的项目将允许扩展受试者池，已知的产前MEHG暴露于大约4,678名受试者。在拟议项目的结束时，我们将估计产前MEHG暴露与SCQ分数之间的关联。如果由结果保证，则可以使用标准诊断程序来进一步研究这种新特征的队列，以阐明MEHG和ASD之间的关联，并确定已知在怀孕期间因鱼类消耗而高暴露于MEHG的人群中ASD的患病率。科学家和政策制定者之间的关注点正在增加，即接触甲基汞和ASD表型之间可能存在联系。没有公开的人类研究，已经确定了产前暴露于甲基汞的，并且后代已经测试了ASD。塞舌尔儿童发展研究提供了一个难得的机会来检验以下假设，即ASD和甲基汞在食用中存在关联。