14th International Conference on HIV Treatment, Pathogenesis, and Prevention Research (INTEREST)

第14届国际艾滋病毒治疗、发病机制和预防研究会议（INTEREST）

• 批准号: 10012378
• 负责人: Guido Ferrari
• 金额: $ 4.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-06 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10012378
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adult; Advisory Committees; Africa; Africa South of the Sahara; African; Age; Award; CD4 Lymphocyte Count; Career Choice; Cessation of life; Child; Clinical; Collaborations; Communities; Development; Diagnosis; Doctor of Philosophy; Early Diagnosis; Ebola; Elderly; Ensure; Epidemic; Event; Fostering; Future; Goals; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; HIV-1; HIV/TB; Health; Health Care Research; Health Policy; Health Services; Health financing; Hepatitis C; Human Resources; Human immunodeficiency virus test; Individual; Infection; Institutes; International; Investments; Knowledge; Leadership; Leprosy; Malaria; Measures; Oral; Outcome; Pathogenesis; Physicians; Prevention; Prevention Research; Prevention strategy; Public Health; Ramp; Reporting; Research; Research Personnel; Resources; Science; Scientist; Social Work; Training; Travel; Treatment Protocols; Treatment Step; Tuberculosis; Uganda; Viral; Viral Drug Resistance; Viral Load result; Vocational Guidance; Work; Youth; aged; antiretroviral therapy; base; behavioral/social science; career development; clinical care; comorbidity; cost; cost effective; demographics; disparity reduction; effective therapy; evidence base; experience; fight against; girls; global health; implementation science; mHealth; meetings; men; mortality; novel; pandemic disease; pathogen; peer; prevent; programs; research and development; response; scale up; stem; symposium; transmission process; treatment strategy; young woman

Abstract. The most recent UNAIDS estimates of the global burden of HIV are that 36.9 million people are living with HIV-1 infection worldwide, with 69.4% of these residing in sub-Saharan Africa. Markedly, three in four new infections in sub-Saharan Africa are among girls aged 15–19 years and young women aged 15–24 years are twice as likely to be living with HIV than men that age. Further, a striking difference exists between the east/southern and the west/central regions of sub-Saharan Africa, with reductions in AIDS-related deaths since 2010 of 42% and 24%, respectively. Clearly, much work remains in terms of training local physicians and scientists in the diagnosis, treatment, and management of individuals with HIV-1 infection; conducting implementation science to determine the most cost-effective use of financial and human resources; and ensuring evidence-informed public health policy and programming to reduce disparities in the AIDS response across Africa’s sub-regions. Despite treatment likely having contributed to slowing HIV transmission, HIV prevention remains critical to stem the tide of HIV. In fact, a second AIDS pandemic in the next 12 years is predicted due to 1) changing demographics in Africa with increasing numbers of youth, 2) increasing transmitted viral drug resistance, and 3) increased cost and limited availability of 2nd and 3rd line treatment regimens. Taken together, these factors suggest that the total number of people living with AIDS may increase by 2 million/year to reach a staggering 50 million worldwide by 2030. Since 2007, 13 successful annual INTEREST Conferences, known as the ‘African CROI’, have brought together scientists involved in HIV diagnosis and treatment, pathogenesis, and prevention research in resource-limited settings in Africa to share pivotal findings, promote collaboration, and transfer experiences across several fields and many continents. Planning and organization of the 2020 INTEREST Conference will be overseen by the Amsterdam Institute of Global Health and Development. Catherine Hankins MD PhD chairs INTEREST’s International Conference Committee (ICC) and is the Scientific Chair of INTEREST. The organizers of the 2020 INTEREST Conference will pursue the following objectives: 1) To provide cutting-edge knowledge in the fields of diagnosis and treatment, pathogenesis, and prevention of HIV-1 for adults, including the elderly; adolescents; and children living with HIV in Africa, in order to contribute to achieving the 90-90-90 viral suppression goal and to preventing a second great pandemic. 2) To foster new research interactions among leading investigators and those who represent the potential future scientific leadership for health care and research on the African continent.

抽象的。 联合国艾滋病规划署 (UNAIDS) 对全球艾滋病毒负担的最新估计是，有 3,690 万人感染艾滋病毒。 全世界都有 HIV-1 感染者，其中 69.4% 居住在撒哈拉以南非洲地区，尤其是 3 人。 撒哈拉以南非洲地区 4 例新感染者中 15 至 19 岁的女孩和 15 岁至 19 岁的年轻女性 15-24 岁的人感染艾滋病毒的可能性是同龄男性的两倍。此外，这是一个显着的差异。 存在于撒哈拉以南非洲东部/南部和西部/中部地区之间， 自 2010 年以来，与艾滋病相关的死亡人数分别为 42% 和 24%，显然，在这方面仍有大量工作要做。 对当地医生和科学家进行诊断、治疗和管理方面的培训 HIV-1 感染；进行科学实施，以确定最具成本效益的资金使用方式 和人力资源；并确保公共卫生政策和规划以证据为基础，以减少 尽管治疗可能有所贡献，但非洲各次区域的艾滋病防治工作仍存在差异。 为了减缓艾滋病毒的传播，预防艾滋病毒仍然是遏制艾滋病毒流行的关键。 预计艾滋病将在未来 12 年大流行，原因是 1) 非洲人口结构的变化 青少年人数增加，2) 传播病毒耐药性增加，3) 成本增加 综合来看，二线和三线治疗方案的可用性有限。 艾滋病感染者总数每年可能增加200万，达到惊人的5000万 到 2030 年将覆盖全球。 自 2007 年以来，已成功举办了 13 届年度 INTEREST 会议（被称为“非洲 CROI”） 汇集了参与艾滋病毒诊断和治疗、发病机制和预防的科学家 在非洲资源有限的环境中进行研究，以分享关键发现、促进合作和 跨多个领域和多个大陆传递经验 2020 年的规划和组织。 INTEREST 会议将由阿姆斯特丹全球健康与发展研究所监督。 凯瑟琳·汉金斯 (Catherine Hankins) 医学博士、博士生是 INTEREST 国际会议委员会 (ICC) 主席，也是 兴趣科学主席。 2020年INTEREST会议的组织者将追求以下目标： 1）提供诊疗、发病机制、 成人（包括青少年和感染 HIV-1 的儿童）的预防； 非洲的艾滋病毒，以促进实现 90-90-90 病毒抑制目标并 防止第二次大流行。 2) 促进主要研究者和代表者之间新的研究互动 非洲大陆医疗保健和研究未来潜在的科学领导地位。