Molecular Physiology and Biochemistry of Wilson's disease

威尔逊病的分子生理学和生物化学

• 批准号: 8086727
• 负责人: SVETLANA LUTSENKO
• 金额: $ 50.52万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-23 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8086727
• 关键词: ATP phosphohydrolase; Acute; Affect; Animal Model; Basal Ganglia; Binding; Biochemical; Biochemistry; Brain; Cell Nucleus; Cells; Cerebellum; Chelation Therapy; Complex; Copper; Copper Chelation; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Environment; Enzymes; Event; Gene Expression Profile; Genes; Genotype; Hepatic; Hepatic Form Wilson Disease; Hepatocyte; Hepatolenticular Degeneration; Hereditary Disease; Homeostasis; Human; Individual; Kinetics; Lead; Life; Liver; Liver diseases; Longitudinal Studies; Maintenance; Measurement; Metabolism; Metallothionein; Metals; Methodology; Molecular; Mus; Mutate; Mutation; Neurologic; Neurologic Manifestations; Neurologic Symptoms; Nuclear; Nuclear Protein; Nuclear Proteins; Oxidation-Reduction; Pathology; Pathway interactions; Phenotype; Physiology; Play; Positron-Emission Tomography; Process; Proteins; Proteome; RNA; RNA biosynthesis; RNA-Binding Proteins; Relative (related person); Role; Sampling; Serum; Severities; Specificity; Spectrum Analysis; Staging; Symptoms; Technology; Testing; Tissues; Transcript; Up-Regulation; Wilson disease protein; absorption; base; chelation; copper-transporting ATPase; genetic analysis; hnRNP A2; hnRNP A2-B1; interdisciplinary approach; liver transplantation; mouse model; oxidation; research study; response; tissue/cell culture; uptake