Neurobiology of the Menopausal Transition

更年期过渡的神经生物学

• 批准号: 8150719
• 负责人: YOLANDA R SMITH
• 金额: $ 5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150719
• 关键词: Affective; Age; Age-Years; Aging; Area; Arts; Brain; Cerebrovascular Circulation; Characteristics; Cognition; Cognitive; Collaborations; Communities; Community Health; Conflict (Psychology); Data; Emotional; Estradiol; Estrogen Replacements; Estrogens; Estrone; Follicle Stimulating Hormone; Functional Magnetic Resonance Imaging; Gonadal Steroid Hormones; Hemorrhage; Hippocampus (Brain); Hormones; Image; Intervention; Life; Magnetic Resonance; Measures; Mediating; Menopausal Status; Menopause; Mental Health; Monitor; Moods; Neurobiology; Neuropsychological Tests; Neurotransmitters; Ovarian; Parahippocampal Gyrus; Parietal Lobe; Participant; Pattern; Perimenopause; Population; Postmenopause; Premenopause; Process; Psychological Tests; Recruitment Activity; Relative (related person); Research Personnel; SHBG gene; Secure; Staging; System; Techniques; Test Result; Testing; Time; United States; Woman; Women' s Health; aged; base; bone health; cohort; design; epidemiology study; glucose metabolism; hormone therapy; metabolic abnormality assessment; middle age; neural circuit; neuroimaging; neuropsychological; novel; programs; reproductive; reproductive hormone; senescence

The menopausal transition is an important life process, significantly impacting the cognitive and psychological health of women. Postmenopausal neuroimaging studies of hormone therapy indicate that estrogen levels have signficant effects on brain neural circuitry. However, mechanistic studies of the neurobiology of the menopausal transition are lacking. This proposal combines the rich historical data from and access to a uniquely well-characterized population of women, transitioning the menopause, with neuropsychological testing and state-of-the-art neuroimaging techniques, to characterize the neurobiology of the menopausal transition. To test hypotheses concerning mechanisms of menopausal cognitive and affective changes, we will recruit from a well-characterizedpopulation of women at the mid-life who have been participants in a bone health and metabolism study involving extensive hormone and cycle monitoring since 1992. Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone levels and menstrual bleeding patterns. This collaboration will involve extensive neuropsychological testing combined with a validated functional magnetic resonance (fMRI) imaging paradigm to determine brain activation patterns during cognitive and emotional tasks among women of each panel. The Specific Aims include: 1. Identify if specific stages or characteristics of the menopausal transition are associated with alterations in brain functioning as manifested either by fMRI-BOLD activation during cognitive and emotional tasks or by neuropsychological testing. 2. Delineate the relative contribution of ovarian aging vs chronological aging in brain functioning as manifested either by fMRI-BOLDactivation during cognitive and emotional tasks or by neuropsychological testing. 3. Demonstrate whether cognitive processing changes noted on fMRI-BOLD precede, occur concurrent, or follow observable changes in neuropsychological testing. These studies will determine the contributions of hormones and aging to changes in cognitive and emotional processing. A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women.

更年期过渡是一个重要的生活过程，严重影响了认知和 妇女的心理健康。激素治疗的绝经后神经影像学研究表明 雌激素水平对脑神经回路具有引人注目的影响。但是， 缺乏更年期过渡的神经生物学。该提案结合了丰富的历史数据 并获得了独特的妇女特征人群，使更年期过渡， 神经心理学测试和最新的神经影像学技术，以表征神经生物学 更年期过渡。检验有关更年期认知机制的假设和 情感变化，我们将从对中年的女性招募妇女的招募 曾参与涉及广泛激素和周期监测的骨骼健康和代谢研究 自1992年以来。新兵将是40-55岁的妇女，分为代表前后的面板， 早期围绝经期，晚期末期和自然末期因卵泡刺激而定义 激素水平和月经出血模式。这项合作将涉及广泛 神经心理学测试与经过验证的功能磁共振（fMRI）成像结合 范式确定每个女性的认知和情感任务期间的大脑激活模式 控制板。具体目的包括：1。确定更年期的特定阶段或特征是 过渡与脑功能的变化有关，正如fMRI-bold激活所表现的那样 在认知和情感任务或通过神经心理学测试中。 2。描述相对贡献 卵巢衰老与脑功能衰老的年龄衰老，这要么由fMRI-降低活化表现为 在认知和情感任务或通过神经心理学测试中。 3。证明是否认知 在fMRI-bold之前指出的处理更改，同时发生，或遵循可观察到的变化 神经心理学测试。这些研究将确定激素和衰老对 认知和情感处理的变化。更好地理解大脑的区域和顺序 处理更改将使卫生社区能够计划干预措施，这些干预措施最有效地保留 女性的认知和情感健康。