Neurobiology of the Menopausal Transition

更年期过渡的神经生物学

• 批准号: 8150719
• 负责人: YOLANDA R SMITH
• 金额: $ 5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150719
• 关键词: Affective; Age; Age-Years; Aging; Area; Arts; Brain; Cerebrovascular Circulation; Characteristics; Cognition; Cognitive; Collaborations; Communities; Community Health; Conflict (Psychology); Data; Emotional; Estradiol; Estrogen Replacements; Estrogens; Estrone; Follicle Stimulating Hormone; Functional Magnetic Resonance Imaging; Gonadal Steroid Hormones; Hemorrhage; Hippocampus (Brain); Hormones; Image; Intervention; Life; Magnetic Resonance; Measures; Mediating; Menopausal Status; Menopause; Mental Health; Monitor; Moods; Neurobiology; Neuropsychological Tests; Neurotransmitters; Ovarian; Parahippocampal Gyrus; Parietal Lobe; Participant; Pattern; Perimenopause; Population; Postmenopause; Premenopause; Process; Psychological Tests; Recruitment Activity; Relative (related person); Research Personnel; SHBG gene; Secure; Staging; System; Techniques; Test Result; Testing; Time; United States; Woman; Women' s Health; aged; base; bone health; cohort; design; epidemiology study; glucose metabolism; hormone therapy; metabolic abnormality assessment; middle age; neural circuit; neuroimaging; neuropsychological; novel; programs; reproductive; reproductive hormone; senescence

The menopausal transition is an important life process, significantly impacting the cognitive and psychological health of women. Postmenopausal neuroimaging studies of hormone therapy indicate that estrogen levels have signficant effects on brain neural circuitry. However, mechanistic studies of the neurobiology of the menopausal transition are lacking. This proposal combines the rich historical data from and access to a uniquely well-characterized population of women, transitioning the menopause, with neuropsychological testing and state-of-the-art neuroimaging techniques, to characterize the neurobiology of the menopausal transition. To test hypotheses concerning mechanisms of menopausal cognitive and affective changes, we will recruit from a well-characterizedpopulation of women at the mid-life who have been participants in a bone health and metabolism study involving extensive hormone and cycle monitoring since 1992. Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone levels and menstrual bleeding patterns. This collaboration will involve extensive neuropsychological testing combined with a validated functional magnetic resonance (fMRI) imaging paradigm to determine brain activation patterns during cognitive and emotional tasks among women of each panel. The Specific Aims include: 1. Identify if specific stages or characteristics of the menopausal transition are associated with alterations in brain functioning as manifested either by fMRI-BOLD activation during cognitive and emotional tasks or by neuropsychological testing. 2. Delineate the relative contribution of ovarian aging vs chronological aging in brain functioning as manifested either by fMRI-BOLDactivation during cognitive and emotional tasks or by neuropsychological testing. 3. Demonstrate whether cognitive processing changes noted on fMRI-BOLD precede, occur concurrent, or follow observable changes in neuropsychological testing. These studies will determine the contributions of hormones and aging to changes in cognitive and emotional processing. A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women.

更年期过渡是一个重要的生命过程，显着影响认知和 女性心理健康。激素治疗的绝经后神经影像学研究表明 雌激素水平对大脑神经回路有显着影响。然而，机制研究 缺乏绝经过渡的神经生物学。该提案结合了丰富的历史数据 并接触到具有独特特征的妇女群体，过渡更年期， 神经心理学测试和最先进的神经影像技术，以表征神经生物学 更年期过渡。检验有关更年期认知和功能机制的假设 情感变化，我们将从一群具有良好特征的中年女性中招募 参与了涉及广泛激素和周期监测的骨骼健康和代谢研究 自 1992 年以来。招募的对象是 40-55 岁的女性，分为代表绝经前的小组， 根据卵泡刺激定义的早期围绝经期、晚期围绝经期和自然绝经后 激素水平和月经出血模式。此次合作将涉及广泛 神经心理学测试与经过验证的功能磁共振 (fMRI) 成像相结合 确定每个女性在认知和情感任务期间大脑激活模式的范式 控制板。具体目标包括： 1. 确定更年期的具体阶段或特征 转变与大脑功能的改变相关，如通过 fMRI-BOLD 激活所表明的 在认知和情感任务期间或通过神经心理学测试。 2. 描述相对贡献 卵巢衰老与按时间顺序衰老的大脑功能的关系，通过 fMRI-BOLD 激活来体现 在认知和情感任务期间或通过神经心理学测试。 3. 证明是否具有认知能力 fMRI-BOLD 上记录的处理变化先于、同时发生或遵循可观察到的变化 神经心理学测试。这些研究将确定激素和衰老对衰老的影响 认知和情感处理的变化。更好地了解大脑的区域和顺序 处理变化将使卫生界能够规划最有效地保护的干预措施 女性的认知和情感健康。