Neurobiology of the Menopausal Transition

更年期过渡的神经生物学

基本信息

批准号：
7237289
负责人：
YOLANDA R SMITH
金额：
$ 30.26万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7237289
关键词：
Affective Age Age-Years Aging Area Arts Brain Cerebrovascular Circulation Characteristics Cognition Cognitive Collaborations Communities Community Health Conflict (Psychology)Data Emotional Estradiol Estrogen Replacements Estrogens Estrone Follicle Stimulating Hormone Functional Magnetic Resonance Imaging Gonadal Steroid Hormones Hemorrhage Hippocampus (Brain)Hormones Image Intervention Life Magnetic Resonance Measures Mediating Menopausal Status Menopause Mental Health Monitor Moods Neurobiology Neuropsychological Tests Neurotransmitters Ovarian Parahippocampal Gyrus Parietal Lobe Participant Pattern Perimenopause Population Postmenopause Premenopause Process Psychological Tests Range Recruitment Activity Relative (related person)Research Personnel SHBG gene Secure Staging System Techniques Test Result Testing Time United States Woman Women&apos s Health aged base bone health cohort design epidemiology study glucose metabolism hormone therapy metabolic abnormality assessment middle age neural circuit neuroimaging neuropsychological novel programs reproductive reproductive hormone senescence

项目摘要

DESCRIPTION (provided by applicant): The menopausal transition is an important life process, significantly impacting the cognitive and psychological health of women. Postmenopausal neuroimaging studies of hormone therapy indicate that estrogen levels have significant effects on brain neural circuitry. However, mechanistic studies of the neurobiology of the menopausal transition are lacking. This proposal combines the rich historical data from and access to a uniquely well-characterized population of women, transitioning the menopause, with neuropsychological testing and state-of-the-art neuroimaging techniques, to characterize the neurobiology of the menopausal transition. To test hypotheses concerning mechanisms of menopausal cognitive and affective changes, we will recruit from a well-characterized population of women at the mid-life who have been participants in a bone health and metabolism study involving extensive hormone and cycle monitoring since 1992. Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone levels and menstrual bleeding patterns. This collaboration will involve extensive neuropsychological testing combined with a validated functional magnetic resonance (fMRI) imaging paradigm to determine brain activation patterns during cognitive and emotional tasks among women of each panel. The Specific Aims include: 1. Identify if specific stages or characteristics of the menopausal transition are associated with alterations in brain functioning as manifested either by fMRI-BOLD activation during cognitive and emotional tasks or by neuropsychological testing. 2. Delineate the relative contribution of ovarian aging vs. chronological aging in brain functioning as manifested either by fMRI-BOLD activation during cognitive and emotional tasks or by neuropsychological testing. 3. Demonstrate whether cognitive processing changes noted on fMRI-BOLD precede, occur concurrent, or follow observable changes in neuropsychological testing. These studies will determine the contributions of hormones and aging to changes in cognitive and emotional processing. A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women.

描述（由申请人提供）：更年期过渡是一个重要的生活过程，严重影响了妇女的认知和心理健康。激素治疗的绝经后神经影像学研究表明，雌激素水平对脑神经回路具有重大影响。然而，缺乏对绝经过渡神经生物学的机械研究。该提案结合了从独特的妇女中广泛的历史数据和访问，使更年期过渡，神经心理学测试和最新的神经影像学技术，以表征绝经过渡的神经生物学。 To test hypotheses concerning mechanisms of menopausal cognitive and affective changes, we will recruit from a well-characterized population of women at the mid-life who have been participants in a bone health and metabolism study involving extensive hormone and cycle monitoring since 1992. Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural卵泡刺激激素水平和月经出血模式来定义的。这种合作将涉及广泛的神经心理学测试，并结合经过验证的功能磁共振（fMRI）成像范式，以确定每个面板女性认知和情感任务期间的大脑激活模式。具体目的包括：1。确定绝经过渡的特定阶段或特征是否与脑功能的变化有关，这表现为在认知和情感任务期间的fMRI-bold激活或神经心理学测试。 2。描述卵巢衰老与年代衰老在大脑中的相对贡献，其功能表现为fMRI-bold在认知和情感任务期间的激活或神经心理学测试。 3。证明在fMRI-bold之前，同时发生的认知处理发生变化，还是遵循神经心理学测试的可观察到的变化。这些研究将确定激素和衰老对认知和情感处理变化的贡献。更好地了解大脑处理变化的领域和顺序将使卫生社区能够计划干预措施，这些干预措施最有效地保护女性的认知和情感健康。