NEUROBIOLOGICAL EFFECTS OF LONG-TERM ESTROGEN REPLACEMENT

长期雌激素替代的神经生物学影响

• 批准号: 7376518
• 负责人: YOLANDA R SMITH
• 金额: $ 1.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376518
• 关键词: aging; brain; cognition; dementia; estrogens; hormone therapy; progestins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With the steady increase in our aging female population, issues concerning the maintenance and improvement of the physical and mental health of postmenopausal women are extremely relevant to our society. Aging leads to the deterioration of brain function and a higher incidence of dementias such as Alzheimer's disease (AD). AD is a devastating illness and presents a tremendous economic burden to the country. Since no cures or highly effective therapies exist, preventive strategies are of particular importance in this disease. A number of studies have suggested that estrogen use can enhance cognitive performance and possibly prevent or delay the onset of debilitating dementias. The long-term protective effects of estrogen on cognitive functioning, however, are not clearly established. The goal of our research is to study the aging process in women and evaluate the effects of postmenopausal estrogen therapy on healthy brain function. Furthermore, as the health benefits and risks (i.e. breast cancer) of long-term postmenopausal hormone therapy are debated, information relevant to AD risk and quality of life will assist in appropriate recommendations for the health care of aging women. Sixty women will be recruited through bulletin board announcements, newspaper advertisements and the Women's Health Registry (a database of women interested in participating in clinical research studies). They will be selected so that they are 60 years old or older and have either received hormone therapy without interruption after menopause or no replacement. The subjects will be recruited into three groups, 20 will have never used postmenopausal hormone therapy, 20 will have used estrogen only for at least ten years, and 20 will have used estrogen and progestin for at least ten years. Magnetic Resonance Image (MRI) of anatomy and functional MRI (fMRI) of the brain will be obtained in all study participants. In addition, subjects will undergo a positron emission tomography (PET) scan for the study of a cholinergic neurotransmitter system involved in cognition. Hormone levels will be tested and cognitive tests will be performed. Acquired data will be examined to find out whether estrogen use will have the greatest positive effect on brain capabilities compared to estrogen plus progestin regimen or using no hormones at all.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。随着女性老龄化的稳定增长，关于绝经后妇女的身心健康的维持和改善问题与我们的社会非常相关。衰老会导致脑功能恶化和痴呆症的发病率更高，例如阿尔茨海默氏病（AD）。广告是一种毁灭性的疾病，给该国带来了巨大的经济负担。由于不存在治疗方法或高效疗法，因此预防策略在该疾病中尤为重要。许多研究表明，使用雌激素可以提高认知性能，并可能预防或延迟衰弱的痴呆症的发作。然而，雌激素对认知功能的长期保护作用尚未清楚地确​​定。我们研究的目的是研究女性的衰老过程，并评估绝经后雌激素治疗对健康脑功能的影响。此外，由于对绝经后激素治疗的长期健康益处和风险（即乳腺癌）进行了辩论，因此与AD风险和生活质量有关的信息将有助于为老年妇女的医疗保健提供适当的建议。将通过公告委员会的公告，报纸广告和妇女健康注册表（有兴趣参加临床研究的妇女数据库）招募60名妇女。他们将被选为60岁或以上的年龄，并且在更年期后不中断或没有替代品接受激素治疗。这些受试者将被招募为三组，20个从未使用过绝经后激素治疗，20只只能使用雌激素至少十年，而20种将使用雌激素和孕激素至少十年。在所有研究参与者中，将获得大脑解剖学和功能性MRI（fMRI）的磁共振图像（MRI）。此外，受试者将进行正电子发射断层扫描（PET）扫描，以研究与认知有关的胆碱能神经递质系统。将测试激素水平，并将进行认知测试。将检查获得的数据，以找出与雌激素加孕激素方案相比，雌激素的使用是对脑功能的最大积极作用，还是根本没有使用激素。