NEUROBIOLOGICAL EFFECTS OF LONG-TERM ESTROGEN REPLACEMENT

长期雌激素替代的神经生物学影响

• 批准号: 7376518
• 负责人: YOLANDA R SMITH
• 金额: $ 1.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376518
• 关键词: aging; brain; cognition; dementia; estrogens; hormone therapy; progestins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With the steady increase in our aging female population, issues concerning the maintenance and improvement of the physical and mental health of postmenopausal women are extremely relevant to our society. Aging leads to the deterioration of brain function and a higher incidence of dementias such as Alzheimer's disease (AD). AD is a devastating illness and presents a tremendous economic burden to the country. Since no cures or highly effective therapies exist, preventive strategies are of particular importance in this disease. A number of studies have suggested that estrogen use can enhance cognitive performance and possibly prevent or delay the onset of debilitating dementias. The long-term protective effects of estrogen on cognitive functioning, however, are not clearly established. The goal of our research is to study the aging process in women and evaluate the effects of postmenopausal estrogen therapy on healthy brain function. Furthermore, as the health benefits and risks (i.e. breast cancer) of long-term postmenopausal hormone therapy are debated, information relevant to AD risk and quality of life will assist in appropriate recommendations for the health care of aging women. Sixty women will be recruited through bulletin board announcements, newspaper advertisements and the Women's Health Registry (a database of women interested in participating in clinical research studies). They will be selected so that they are 60 years old or older and have either received hormone therapy without interruption after menopause or no replacement. The subjects will be recruited into three groups, 20 will have never used postmenopausal hormone therapy, 20 will have used estrogen only for at least ten years, and 20 will have used estrogen and progestin for at least ten years. Magnetic Resonance Image (MRI) of anatomy and functional MRI (fMRI) of the brain will be obtained in all study participants. In addition, subjects will undergo a positron emission tomography (PET) scan for the study of a cholinergic neurotransmitter system involved in cognition. Hormone levels will be tested and cognitive tests will be performed. Acquired data will be examined to find out whether estrogen use will have the greatest positive effect on brain capabilities compared to estrogen plus progestin regimen or using no hormones at all.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。随着我国女性人口老龄化的不断增加，维持和改善绝经后妇女身心健康的问题与我们的社会息息相关。衰老会导致大脑功能恶化，并增加阿尔茨海默病（AD）等痴呆症的发病率。 AD 是一种毁灭性的疾病，给国家带来巨大的经济负担。由于不存在治愈或高效疗法，因此预防策略对于这种疾病尤为重要。许多研究表明，使用雌激素可以增强认知能力，并可能预防或延缓衰弱性痴呆的发生。然而，雌激素对认知功能的长期保护作用尚未明确。我们研究的目标是研究女性的衰老过程并评估绝经后雌激素治疗对健康大脑功能的影响。此外，由于长期绝经后激素治疗的健康益处和风险（即乳腺癌）存在争议，与 AD 风险和生活质量相关的信息将有助于为老年女性的医疗保健提供适当的建议。将通过公告栏公告、报纸广告和妇女健康登记处（有兴趣参加临床研究的妇女数据库）招募 60 名妇女。他们将被选择为 60 岁或以上，并且在绝经后不间断地接受激素治疗或不接受替代疗法。受试者将被分为三组，20 人从未使用过绝经后激素治疗，20 人仅使用雌激素至少十年，20 人使用雌激素和孕激素至少十年。所有研究参与者都将获得大脑解剖结构磁共振图像 (MRI) 和大脑功能磁共振成像 (fMRI)。此外，受试者还将接受正电子发射断层扫描（PET）扫描，以研究参与认知的胆碱能神经递质系统。将测试激素水平并进行认知测试。将检查获得的数据，以确定与雌激素加孕激素方案或根本不使用激素相比，使用雌激素是否会对大脑功能产生最大的积极影响。