A stable path for a core based scientist to advance imaging and cytometry in basic and preclinical research at the Karmanos Cancer Institute

为核心科学家在卡马诺斯癌症研究所的基础和临床前研究中推进成像和细胞计数提供了一条稳定的道路

• 批准号: 10026380
• 负责人: KAMIAR MOIN
• 金额: $ 28.06万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10026380
• 关键词: Applications Grants; Basic Science; Cancer Center; Cancer Center Support Grant; Capital; Collaborations; Communities; Computers and Advanced Instrumentation; Confocal Microscopy; Consultations; Continuing Education; Core Facility; Cytometry; Dependence; Educational workshop; Flow Cytometry; Funding; Grant; Image Cytometry; Individual; Institutes; International; Investigator-Initiated Research; Malignant Neoplasms; Methodology; Microscopy; Mission; Multimodal Imaging; Peer Review; Publications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resources; Role; Scientist; Services; Study Section; Techniques; Technology; Time; Tissue imaging; Travel; United States National Institutes of Health; Universities; analytical method; animal imaging; base; career; cellular imaging; confocal imaging; cost; experience; instrument; meetings; member; method development; microscopic imaging; operation; parent grant; pre-clinical research; ranpirnase; research facility; skills; symposium; technology development; technology validation; training opportunity

Abstract This proposal support for a core-based scientist with our Cancer Center Support Grant (CCSG) as the parent grant, seeks career stability for Dr. Kamiar Moin the Director of the Microscopy, Imaging and Cytometry Resources core (MICR) of the Karmanos Cancer Institute (KCI). MICR is the largest facility core of KCI and is funded, in part, by the CCSG (P30-CA022453, Dr. Gerold Bepler PI/Unit Director; Dr. Moin is a co-investigator). Dr. Moin established MICR in 1994 as the Confocal Imaging Core in the Cancer Center and provided cutting- edge expertise and state-of-the-art technology in fluorescent microscopy, confocal microscopy and related techniques. From the beginning with only a 200 ft2 space and one instrument, Dr. Moin has expanded and significantly upgraded the MICR a number of times culminating into the current premier multimodal imaging and flow cytometry service center with over 4000 ft2 space and 22 capital instruments. Dr. Moin’s mission through MICR is to support and enhance the peer reviewed funded research activities of our scientific community whose research requires advanced cytometry as well as cellular, tissue, and animal imaging and analysis. To fulfill this mission, Dr. Moin strives to consistently meet several objectives, which are to: 1) provide expertise in analytical methods development, technology development and validation, imaging and cytometry study design; 2) provide collaboration and consultation for grant proposals and publications; 3) provide and maintain state-of-the-art advanced instrumentation in flow cytometry, microscopy and imaging; 4) promote opportunities for intra- and inter-programmatic interaction among our scientific members; 5) minimize cost and effort for KCI investigators while increasing efficiency and 6) provide educational and training opportunities in microscopy, imaging and flow cytometry. Dr. Moin is a nationally and internationally recognized expert and leader in imaging and cytometry, evident by his service on 18 NIH study sections and numerous presentations and workshops, with over 30 years of experience and more than two decades of facility core management and administrative skills. His expertise in imaging and cytometry with a proven track record in technology and methods development is critical to the CCSG and the 25 NCI funded investigator-initiated research projects utilizing MICR. This application, if funded, will support 100% of his efforts and will offset some of the costs incurred by the individual NCI funded projects by reducing the chargeback rates. The R50 will provide career stability without dependence on individual grant and allows him to prioritize his effort on those projects that require methodology and technology development. The funds requested for travel will enable Dr. Moin to attend conferences in imaging and cytometry and/or core facility management meetings such as the Association of the Biomolecular Research Facilities (ABRF), to continue his education in imaging/cytometry and core management to be effective in his role to support the NCI funded projects.

抽象的 该提案以我们的癌症中心支持补助金 (CCSG) 作为核心科学家的支持 家长资助，为显微镜、成像和细胞计数主任 Kamiar Moin 博士寻求职业稳定性 卡马诺斯癌症研究所 (KCI) 的资源核心 (MICR) 是 KCI 最大的设施核心。 部分由 CCSG 资助（P30-CA022453，Gerold Bepler 博士 PI/单位主任；Moin 博士是联合研究员）。 Moin 博士于 1994 年建立了 MICR 作为癌症中心的共焦成像核心，并提供切割- 荧光显微镜、共焦显微镜及相关领域的前沿专业知识和最先进的技术 从一开始，Moin 博士就只有 200 平方英尺的空间和一台仪器，并不断扩展和发展。 对 MICR 进行了多次显着升级，最终成为当前首屈一指的多模态成像 流式细胞术服务中心拥有超过 4000 平方英尺的空间和 22 台资本仪器。 MICR 旨在支持和加强我们科学界的同行评审资助的研究活动，这些活动 研究需要先进的细胞计数以及细胞、组织和动物成像和分析来实现这一目标。 Moin 博士致力于始终如一地实现几个目标，这些目标是： 1) 提供分析方面的专业知识 方法开发、技术开发和验证、成像和细胞计数研究设计2) 3) 为拨款提案和出版物提供协作和咨询； 3) 提供和维护； 流式细胞仪、显微镜和成像领域最先进的仪器 4) 促进 5) 尽量减少我们的科学成员之间的计划内和计划间互动的机会； 减少 KCI 研究人员的成本和精力，同时提高效率，6) 提供教育和培训 Moin 博士是国内外显微镜、成像和流式细胞术领域的工作机会。 成像和细胞计数领域公认的专家和领导者，他在 NIH 18 个研究部门的服务就证明了这一点 多次演讲和研讨会，拥有 30 多年的经验和 20 多年的设施 他在成像和细胞术方面拥有核心管理和行政技能，并拥有良好的业绩记录。 技术和方法开发对于 CCSG 和 25 个 NCI 资助的研究者发起的至关重要 利用 MICR 的研究项目。如果获得资助，该申请将支持他 100% 的努力，并将抵消一些 R50 将通过降低退款率来减少各个 NCI 资助项目的成本。 提供职业稳定性而不依赖于个人资助，并允许他优先考虑他的努力 那些需要方法和技术开发的项目将需要差旅费。 使 Moin 博士能够参加成像和细胞计数会议和/或核心设施管理会议，例如 作为生物分子研究设施协会（ABRF），继续他的教育 成像/细胞术和核心管理，以有效地支持 NCI 资助的项目。