LONGITUDINAL EFFECTS OF TREATMENT ON BRAIN FUNCTION IN CHILDREN WITH TOURETTE SYN

治疗对抽动秽语综合症儿童脑功能的纵向影响

• 批准号: 8115128
• 负责人: Bradley L Schlaggar
• 金额: $ 22.57万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115128
• 关键词: Address; Adolescent; Affect; Aftercare; Age; Basal Ganglia; Behavioral; Biological Markers; Brain; Brain region; Child; Childhood; Chronic; Clinical; Corpus striatum structure; Development; Disease; Early Diagnosis; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Genetic; Gilles de la Tourette syndrome; Goals; Individual; Individual Differences; Intervention; Magnetic Resonance Imaging; Measures; Methods; Motor Tics; Participant; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Physicians; Process; Psychometrics; Quality of life; Reaction Time; Regulation; Rest; Scanning; Severities; Structure; Symptoms; System; Techniques; Testing; Time; Vocal Tics; base; cognitive function; effective therapy; executive function; experience; frontal lobe; improved; mind control; neuropsychiatry; outcome forecast; public health relevance; treatment effect

DESCRIPTION (provided by applicant): Tourette Syndrome (TS) is a common genetic pediatric neuropsychiatric disorder. Manifest as chronic motor and vocal tics, it affects approximately 0.3-1% of children, with significant negative impact on quality of life. TS is associated with deficits in impulse regulation and executive control functions. The brain's executive control systems are thought to be anatomically separate from downstream moment-to-moment processing systems and to consist of networks of functionally diverse regions. The interactions of these control systems with processing systems have been implicated in TS. A key idea underlying this exploratory proposal is that TS arises from the atypical development of networks of control regions and their interactions, as opposed to the atypical functioning of any particular brain region. Medications that relieve tics in TS may also result in an improvement in control abilities, and a normalization of both evoked activity within control regions and of functional connectivity between regions comprising control networks. We hypothesis that the anomalous patterns of brain activation and functional connectivity observed in TS will be ameliorated by medications that treat TS. Understanding the brain's control networks are affected by medications may lay the foundation for earlier diagnosis and more effective therapies for TS and other pediatric neuropsychiatric disorders. PUBLIC HEALTH RELEVANCE: This proposal aims to use longitudinal task-based fMRI and functional connectivity MRI to characterize the development of control networks in pediatric Tourette Syndrome and how those networks respond to pharmacotherapeutic intervention. Understanding how networks of brain regions involved in control are affected by pharmacotherapy in patient with Tourette Syndrome may lay the foundation for earlier diagnosis, more accurate prognosis, and more effective therapies

描述（由申请人提供）：Tourette综合征（TS）是一种常见的遗传儿科神经精神疾病。表现为慢性运动和声音抽动，它影响了约0.3-1％的儿童，对生活质量产生了重大负面影响。 TS与冲动调节和执行控制功能的缺陷有关。大脑的执行控制系统被认为是解剖学上与下游矩之间的处理系统分开的，并且由功能多样的区域组成。这些控制系统与处理系统的相互作用与TS有关。这项探索性建议的一个关键思想是，TS是由控制区域网络及其相互作用的非典型发展引起的，而不是任何特定大脑区域的非典型功能。减轻TS中抽动的药物也可能会提高控制能力，并在控制区域内的诱发活性和包括控制网络的区域之间的功能连通性的归一化。我们假设在TS中观察到的大脑激活和功能连通性的异常模式将通过治疗TS的药物来改善。了解大脑的控制网络受药物的影响可能为早期诊断和对TS和其他儿科神经精神疾病的更有效疗法奠定基础。 公共卫生相关性：该提案旨在使用基于纵向任务的fMRI和功能连接性MRI来表征儿科图雷特综合征中控制网络的开发以及这些网络如何应对药物治疗干预措施。了解对照组综合症患者的药物治疗的影响如何受到对照组疗法的影响，这可能为早期诊断，更准确的预后和更有效的疗法奠定基础