UNC Integrated Translational Oncology Program (UNC-iTOP)

北卡罗来纳大学综合转化肿瘤学项目 (UNC-iTOP)

• 批准号: 10021631
• 负责人: WILLIAM Y. KIM
• 金额: $ 57.94万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10021631
• 关键词: oncology program

Abstract The University of North Carolina at Chapel Hill Integrated Translational Oncology Program (UNC-iTOP) is a T32 training program focused on training clinicians (MDs), basic scientists (PhDs), and PhD, MD and MD-PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. We have recruited preceptors/faculty with broad interests who are committed to improving translational oncology and tissue-based research. Led by two physician-scientists with complementary expertise in tissue-based research, clinically applicable preclinical models, and clinical trials, UNC-iTOP has recruited preceptors/faculty who are leaders in their fields. The UNC-iTOP faculty includes members with expertise in translational research focusing on biomarkers of cancer and novel therapies and interventions for patients. All UNC-iTOP faculty have approved IRB protocols and have led prospective clinical protocols and/or trials. Support for UNC-iTOP will enable a proactive, energetic and sustained effort to identify, recruit and train promising MD, PhD, and MD-PhD investigators for research careers that will address the knowledge gap in tissue-based translational oncology research. Translational oncology tissue-based research has been critically important for the identification of key drivers of cancer initiation, progression and metastasis. Identifying treatments that target the vulnerabilities at each stage continues to be a broad area of need. Evaluating new therapies in relevant models with more stringent metrics is key to translating findings to the clinic. Validating findings in patients is the overarching goal. To succeed in each area requires a fundamental understanding of the workings of the healthcare and clinical protocol/regulatory system that supports cutting edge research. UNC-iTOP will provide a comprehensive training program for MD and PhD trainees committed to translational oncology and tissue-based research. We recognize that translational oncology research involves numerous disciplines and successful advances are the result of interdisciplinary teams. The UNC-iTOP focuses on integrating the “basic”, “clinical”, and “regulatory” teams early on with the overarching goal to develop a cadre of translational scientists (both MDs and PhDs) who will be the next generation of leaders in the field of oncology research.

抽象的 北卡罗来纳大学教堂山分校综合转化肿瘤学项目 (UNC-iTOP) 是一个 T32培训计划重点培养圣人（MD）、基础科学家（PhD）、博士、医学博士和医学博士-博士 临床肿瘤学和癌症交叉领域的临床/转化疾病研究候选人 我们招募了具有广泛兴趣的导师/教师，他们致力于使用患者样本进行生物学研究。 由两位医师科学家领导，改善转化肿瘤学和组织研究。 基于组织的研究、临床适用的临床前模型和临床试验方面的互补专业知识， UNC-iTOP 招募了各自领域的领导者/教师。 UNC-iTOP 教师包括。 具有转化研究专业知识的成员，重点关注癌症生物标志物和新疗法 所有 UNC-iTOP 教员均已批准 IRB 方案并领导了前瞻性临床。 方案和/或试验。 对 UNC-iTOP 的支持将使我们能够积极主动、积极和持续地努力识别、招募和培训 有前途的医学博士、博士和医学博士-博士研究人员的研究生涯将解决以下领域的知识差距 基于组织的转化肿瘤学研究 基于组织的转化肿瘤学研究一直受到批评。 对于识别癌症发生、进展和转移的关键驱动因素非常重要。 针对每个阶段的脆弱性的治疗方法仍然是一个广泛的需要评估新领域的领域。 具有更严格指标的相关模型中的治疗是将研究结果转化为临床的关键。 患者的研究结果是总体目标。要在每个领域取得成功，需要对以下方面有基本的了解。 支持前沿研究的医疗保健和临床方案/监管系统的运作。 UNC-iTOP 将为致力于转化的医学博士和博士生提供全面的培训计划 我们认识到转化肿瘤学研究涉及众多领域。 UNC-iTOP 的学科和成功进步是跨学科团队的成果。 尽早整合“基础”、“临床”和“监管”团队，以培养一支骨干队伍为总体目标 转化科学家（医学博士和博士），他们将成为该领域的下一代领导者 肿瘤学研究。