Monitoring and Delivery of Transcranial Therapy Using Dual-mode Ultrasound

使用双模超声监测和实施经颅治疗

• 批准号: 9262016
• 负责人: Emad S. Ebbini
• 金额: $ 40万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9262016
• 关键词: Address; Adult; Algorithms; Attention; Bilateral; Blood - brain barrier anatomy; Brain; Brain Diseases; Cancer Patient; Chronic; Clinical; Data; Development; Epilepsy; Essential Tremor; Excision; Exposure to; Face; Feedback; Focused Ultrasound; Focused Ultrasound Therapy; Frequencies; Heating; Human; Image; Institute of Medicine (U.S.); Investigation; Left; Lesion; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Mediating; Methods; Mind; Modality; Modeling; Monitor; Operative Surgical Procedures; Patients; Pattern; Pharmaceutical Preparations; Physiologic pulse; Play; Probability; Publishing; Rattus; Real-Time Systems; Reporting; Research; Research Personnel; Resolution; Risk; Rodent; Role; Safety; Sampling; Scalp structure; Spatial Distribution; Spottings; Structure; Surveys; System; Techniques; Temporal Lobe Epilepsy; Testing; Therapeutic; Thermography; Time; Tissues; Treatment outcome; Ultrasonography; Uncertainty; United States; Work; abstracting; attenuation; base; brain tissue; clinical application; cranium; design; image guided; imaging modality; improved; in vivo; interest; millimeter; millisecond; neuroregulation; novel strategies; phase 1 study; prototype; soft tissue; success; tool; transmission process; tumor ablation

Abstract: Transcranial focused ultrasound (tFUS) is gaining increased attention as a noninvasive tool for a number of therapies, e.g. essential tremor, neuromodulation, tumor ablation, etc. In addition, recent results demonstrating the feasibility tFUS-mediated blood brain barrier opening promise to extend the therapeutic applications of tFUS to a myriad of conditions and diseases of the brain. The majority of the published work employ MRI for monitoring and, in some applications, control of tFUS exposure or its bioeffects. While this imaging modality has proved to be essential to advancing tFUS applications so far, the precise delivery of localized tFUS still faces major challenges due to the uncertainties of wave propagation through the skull. This could present a major barrier towards the widespread safe and efficacious use of FUS in transcranial therapies. The long-term objective is to develop a real-time system for monitoring and delivering transcranial FUS therapies in patients using dual-mode ultrasound (DMUA) systems. DMUAs are capable of operating in both therapy and imaging modes in real-time allowing for immediate feedback on tFUS-tissue interactions at the target as well as the intervening and surrounding tissues, including the scalp and skull. We propose to develop real-time refocusing algorithms to improve the safety and efficacy of tFUS therapy of targeted structures within the brain. We present preliminary data demonstrating the feasibility of refocusing and propose to extend our results to wideband tFUS application. This approach maximizes the bandwidth of the imaging/therapy pulses to improve the localization and heating efficiency at the target while minimizing exposure to the skull. The DMUA approach is uniquely capable of providing this kind of feedback due to the inherent registration between the imaging and therapeutic coordinate systems. In addition to the multiband adaptive refocusing method, we propose to develop imaging methods to characterize the quality of tFUS in vivo and ex vivo at the target and critical points on the skull. This includes the development of a quantitative method to estimate the heating rate. This quantitative measurement will provide specific feedback for assessing the improvement due to adaptive refocusing. Finally, we propose to test and validate the refocusing and heating rate estimation method in vivo rat model of chronic temporal lobe epilepsy.

抽象的： 作为多个许多人的无创工具，经颅聚焦超声（TFU）正在增加关注 疗法，例如基本震颤，神经调节，肿瘤消融等。此外，最近的结果表明 可行性TFU介导的血脑屏障开口有望将TFU的治疗应用扩展到 大脑的无数疾病和疾病。大多数已发表的工作员工MRI进行监控 在某些应用中，控制TFUS暴露或其生物效应。虽然已证明这种成像方式是 到目前为止，对于推进TFUS应用程序至关重要，局部TFU的精确交付仍然面临主要挑战 由于颅骨传播波的不确定性。这可能会带来一个主要的障碍 在经颅疗法中宽度安全且有效地使用FUS。长期目标是开发 使用双模式超声检查的患者监测和输送thrancranial FUS疗法的实时系统 （DMUA）系统。 DMUA能够实时在治疗和成像模式下运行，以便 立即对目标的TFU组织相互作用以及中间和周围组织的反馈， 包括头皮和头骨。我们建议开发实时重新聚焦算法以提高安全性和 大脑内靶结构的TFU疗法的效率。我们提供了证明的初步数据 重新集中和提议将结果扩展到宽带TFUS应用程序的可行性。这种方法 最大化成像/治疗脉冲的带宽以提高位置和加热效率 目标同时最大程度地减少对头骨的接触。 DMUA方法具有独特的能力 由于成像和治疗坐标系之间的继承注册而导致的反馈。此外 对于多频道自适应重新聚焦方法，我们建议开发成像方法以表征质量 tfus in Vivo和Ex vivo在靶标和颅骨上的临界点。这包括开发 定量方法估计加热速率。这种定量测量将为 评估由于自适应重新聚焦而导致的改进。最后，我们建议测试和验证重新关注和 慢性临时叶癫痫的体内大鼠模型中的加热率估计方法。