CRCNS: Where to Look Next? Modeling Eye Movements in Normal and Impaired Vision

CRCNS：下一步该往哪里看？

基本信息

批准号：
7784064
负责人：
LAURA LYNN WALKER
金额：
$ 36.93万
依托单位：
SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7784064
关键词：
Accounting Affect Age related macular degeneration Awareness Behavior Bilateral Binding Central Scotomas Clinical Computer Simulation Crowding Discrimination Disease Educational process of instructing Elderly Entropy Evaluation Exhibits Eye Movements Generations Goals Human Image Individual Lasers Learning Link Location Macular degeneration Maps Measurement Measures Methods Modeling Motivation Motor Noise Ophthalmoscopes Outcome Patient observation Patients Pattern Perception Performance Peripheral Property Public Health Rehabilitation Outcome Rehabilitation therapy Relative (related person)Residual state Resolution Saccades Sampling Scanning Scotoma Series Shapes Simulate Source Stimulus System Task Performances Testing Time Uncertainty Vision Visual Visual impairment Work base design disorder of macula of retina effectiveness measure functional outcomes gaze improved model development oculomotor predictive modeling public health relevance rehabilitation science research study sample fixation visual information

项目摘要

DESCRIPTION (provided by applicant): The goal of this work is to develop an explanatory and predictive model of eye movement planning in normal and low vision that can be used to objectively design and measure the effectiveness of low vision rehabilitation. In the previous project period, we developed a quantitative measure of eye movement efficiency and found that inefficiencies among maculopathy patients could not be explained simply by the extent of their central field loss. Thus, there must be additional factors that impair the eye movement strategies in these patients. In this proposal, we further develop our computational model to predict human saccade behavior in addition to fixation placement. The first two aims will empirically measure how and whether motor error limits saccade amplitude and direction. The third aim seeks to improve upon previous endeavors to establish a natural causal link between eye movement generation and stimulus uncertainty. The final aim applies the revised model to probe a possible source of eye movement inefficiency in maculopathy patients: we test the hypothesis that patients retain a "normal" internal template of their vision instead of a veridical representation of their central field loss. This hypothesis is consistent with clinical observations that patients' typically begin complaining about their vision only when bilateral scotomas exceed 10deg, and that teaching "scotoma awareness" can improve functional outcome. Our computational model will continue to provide a conceptual framework for challenging clinical hypotheses, with the eventual goal of transforming low vision rehabilitation practice into rehabilitation science.

描述（由申请人提供）：这项工作的目的是在正常和低视力中开发一种解释性和预测性的眼动计划模型，可用于客观地设计和衡量低视力康复的有效性。在上一个项目期间，我们开发了一种定量衡量眼动效率的量度，发现大肿瘤病患者的效率低下不能仅仅因其中央野外损失的程度来解释。因此，必须有其他因素损害这些患者的眼动策略。在此提案中，我们进一步开发了计算模型，以预测人类扫视行为，除了固定放置。前两个目标将在经验上衡量运动误差如何以及是否限制扫视幅度和方向。第三个目标旨在改善以前的努力，以在眼睛运动和刺激不确定性之间建立自然的因果关系。最终目的应用修订的模型来探测刺激患者的眼睛运动效率低下的可能来源：我们测试了一个假设，即患者保留了视力的“正常”内部模板，而不是其中央场损失的垂直表示。该假设与临床观察结果一致：患者通常只有在双侧SCOTOMA超过10DEG时才开始抱怨自己的视力，而教学“ Scotoma意识”可以改善功能结果。我们的计算模型将继续为具有挑战性的临床假设提供概念框架，并最终将低视力康复实践转变为康复科学的目标。