Reaching with Central Field Loss

达到中心场损失

• 批准号: 8438231
• 负责人: LAURA LYNN WALKER
• 金额: $ 36.9万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8438231
• 关键词: Adolescent; Adopted; Adult; Age; Age Factors; Age related macular degeneration; Anecdotes; Behavior; Behavioral; Central Scotomas; Clinic; Clinical; Communities; Data; Data Set; Disease; Elderly; Eye; Eye Movements; Hand; Individual; Lasers; Life; Location; Longevity; Macular degeneration; Manuals; Maps; Motor; Movement; Neurosciences; Ophthalmoscopes; Optical Coherence Tomography; Outcome Study; Patients; Performance; Perimetry; Peripheral; Play; Population; Preparation; Property; Public Health; Reading; Rehabilitation therapy; Relative (related person); Research; Research Personnel; Resolution; Resources; Response Latencies; Retinal; Role; Saccades; Scanning; Scotoma; Series; Signal Transduction; Speed; System; Tea; Tissues; Training; Vision; Vision Tests; Visual; Visual impairment; Work; cohort; cost; disorder of macula of retina; experience; eye hand coordination; fovea centralis; functional outcomes; illness length; improved; macula; monocular; normal aging; oculomotor; programs; public health relevance; research study; visual feedback

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a leading cause of visual impairment in our elder population. In healthy vision, the fovea plays a critical role in gathering high resolution information about the visual world. We use this information for localizing objects during the preparation and execution of reaching movements. When the fovea and surrounding tissues cease to function, a blindspot (or scotoma) occurs in central vision, and AMD patients must adopt new eye-hand coordination strategies. Most research in eye movement control for AMD patients has concentrated on "eccentric viewing" (i.e. using peripheral vision to see objects) and on reading strategies. Almost no research has been conducted on the important adaptations that must take place for eye-hand coordination to be effective in daily tasks, such as making a sandwich or pouring a cup of tea. As we develop our understanding of adaptations that benefit (or impair) functional outcome for AMD patients, we can utilize this information to improve rehabilitation programs. The work in this proposal is divided into three aims. The first examines to what extent reaching delays and errors can be attributed to normal acuity decline in the periphery. The second examines how central field loss contributes to misdirected eye movements that impair eye-hand coordination. The third aim examines whether and how oculomotor and reaching adaptation occurs as a function of age and disease duration. We will construct a dataset on reaching and eye movements collected from normal, AMD and juvenile macular degeneration (JMD) observers over a large age range (40-100). We will share this dataset publicly so that we and others may use it as a resource to investigate the factors of age, disease and adaptive strategies on eye- hand coordination. The outcomes of this study will further our understanding of the functional impact of central field los, and will also be of significance to basic researchers in sensorimotor integration.

描述（由申请人提供）：与年龄相关的黄斑变性（AMD）是我们老年人群视觉障碍的主要原因。 在健康的视野中，中央凹在收集有关视觉世界的高分辨率信息中起着至关重要的作用。 在准备和执行到达运动过程中，我们使用此信息来定位对象。 当中央凹和周围的组织不再起作用时，盲点（或Scotoma）发生在中央视力中，AMD患者必须采用新的眼手配位策略。 大多数针对AMD患者的眼动控制的研究都集中在“偏心观看”（即使用外围视觉查看物体）和阅读策略上。 几乎没有对重要改编的研究进行的研究，这些改编必须使眼手协调在日常任务中有效，例如制作三明治或倒一杯茶。 随着我们对AMD患者有益于（或损害）功能结果的适应性的理解，我们可以利用这些信息来改善康复计划。 该提案中的工作分为三个目标。 第一个检查的延迟和错误在多大程度上归因于外围的正常敏锐度下降。 第二个研究中央场损失是如何导致损害眼部配位的误导性眼动运动的。 第三个目标研究了动眼运动和如何达到适应性，这是年龄和疾病持续时间的函数。 我们将构建一个数据集，以从正常，AMD和少年黄斑变性（JMD）观察者（40-100）（40-100）中收集到眼睛运动。 我们将公开分享该数据集，以便我们和其他人可以将其用作研究年龄，疾病和手动协调的适应性策略的因素。 这项研究的结果将进一步了解中央场LOS的功能影响，并且对于感觉运动整合中的基础研究人员也很重要。