Axially-resolved Spectroscopic Ophthalmic Imaging

轴向分辨光谱眼科成像

基本信息

批准号：
8860986
负责人：
Alfredo Dubra
金额：
$ 35.98万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8860986
关键词：
Accounting Affect Age related macular degeneration American Biological Markers Blindness Cell Death Cells Cellular Structures Chemicals Clinical Color Complex Data Detection Diagnosis Diagnostic Disease Early Diagnosis Epiretinal Membrane Eye Eye diseases Feedback Financial compensation Fluorescein Angiography Fundus photography General Practitioners Generations Goals Grant Health Human Image Imagery Individual Judgment Knowledge Light Location Macular Hole Measurement Membrane Methods Microscopic Monitor Noise Ophthalmologist Ophthalmoscopes Ophthalmoscopy Optics Optometrist Outcome Pathology Performance Population Publishing Research Resolution Retina Retinal Retinal Diseases Scanning Sensitivity and Specificity Serous Signal Transduction Site Spectrum Analysis Structure Technology Testing Thick Traction Translating Variant Vision adaptive optics base c new cell type design improved lens new technology novel prevent public health relevance spectroscopic imaging tool

项目摘要

DESCRIPTION (provided by applicant): Early detection of eye disease is critical for preventing vision loss that affects more than 38 million Americans. Current diagnostic tools often reveal retinal changes only after vision loss has already occurred. Tests of visual function are limited by their subjectivity, and by the pooling of signals from tens to thousands of retinal cells. Tests of retinal structure are limited by the substantial anatomical variation among individuals, which makes early disease detection impossible without baseline measurements. In most cases structural tests can therefore detect only macroscopic changes that follow major cell death. These limitations could be overcome by a non-invasive method to detect chemical changes that precede cell death. For this purpose, we will develop two novel technologies, adaptive longitudinal chromatic aberration (LCA) correction and axially- resolved hyperspectral retinal imaging. These will be demonstrated in combination with ophthalmic adaptive optics, to characterize the spectra of idiopathic epiretinal membranes, with or without associated retinal traction or macular hole, as well as age-related macular degeneration and central serous retinopathy.

描述（由申请人提供）：早期发现眼部疾病对于预防影响超过 3800 万美国人的视力丧失至关重要。目前的诊断工具通常只有在视力丧失已经发生后才能发现视网膜变化。视觉功能测试因其主观性而受到限制。，并且通过汇集来自数十到数千个视网膜细胞的信号，视网膜结构的测试受到个体之间巨大的解剖学差异的限制，这使得在没有基线测量的情况下无法进行早期疾病检测，因此在大多数情况下结构测试只能检测。主要细胞死亡后的宏观变化可以通过非侵入性方法来检测细胞死亡前的化学变化来克服，为此，我们将开发两种新技术：自适应纵向色差（LCA）校正和轴向色差。这些将与眼科自适应光学相结合进行演示，以表征特发性视网膜前膜的光谱，无论是否有相关的视网膜牵引或黄斑裂孔，以及年龄相关性黄斑变性和中心性浆液性视网膜病变。