Increasing the isoplanatic patch in adaptive optics ophthalmoscopy

增加自适应光学检眼镜中的等晕斑块

基本信息

批准号：
10403622
负责人：
Alfredo Dubra
金额：
$ 47.51万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-03-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY The optics of the eye suffer from imperfections (wavefront aberrations) that blur retinal images. This blur limits our ability to diagnose eye disease before irreversible damage and vision loss take place. Adaptive optics (AO) ophthalmoscopy can correct for this blur, which is unique to each eye and retinal location. Current AO ophthalmoscopes can only capture images of very small retinal areas because they cannot correct for the variation of the wavefront aberrations across the retina. This limitation impedes the use of this technology for detecting early signs of disease, which in turn, enable the early treatment that would mitigate irreversible vision loss. Here we propose to first measure how wavefront aberrations change across the retina in a human subject population to improve the design and operation of all future AO ophthalmoscopes. We also propose two novel methods for measuring and correcting wavefront aberrations that vary across the retina to increase the field of view of these instruments. First, we propose to measure aberrations sequentially at various points in the field of view and then deliver appropriate sequential wavefront corrections at each retinal location. This low-cost, low complexity approach could be used to double the retinal coverage of current AO scanning ophthalmoscopes. The second approach uses two wavefront correctors, the optimal axial positions of which will be determined by using the data on wavefront aberration changes with retinal location and wavelength across the population. This more complex approach aims to at least quadruple retinal coverage. The resulting increase in the field of view will be a major step towards translating AO ophthalmoscopy into a practical clinical tool for improving the diagnosis and treatment of eye diseases.

项目概要眼睛的光学系统存在缺陷（波前像差），导致视网膜图像模糊。这种模糊限制了我们有能力在发生不可逆转的损伤和视力丧失之前诊断眼部疾病。自适应光学 (AO) 检眼镜可以纠正这种模糊，这种模糊对于每只眼睛和视网膜位置来说都是独一无二的。当前AO 检眼镜只能捕获非常小的视网膜区域的图像，因为它们无法校正视网膜上波前像差的变化。这一限制阻碍了该技术的使用检测疾病的早期迹象，从而能够进行早期治疗，从而减轻不可逆视力损失。在这里，我们建议首先测量人类受试者视网膜上的波前像差如何变化人口改善所有未来 AO 检眼镜的设计和操作。我们还推荐两本小说测量和校正在视网膜上变化的波前像差以增加视场的方法查看这些仪器。首先，我们建议在领域的各个点顺序测量像差查看然后在每个视网膜位置提供适当的顺序波前校正。这种低成本、低复杂性方法可用于将当前 AO 扫描检眼镜的视网膜覆盖范围加倍。第二种方法使用两个波前校正器，其最佳轴向位置将由下式确定使用波前像差随人群视网膜位置和波长变化的数据。这更复杂的方法旨在将视网膜覆盖率至少增加四倍。由此产生的视野增加将是将 AO 检眼镜转化为实用的临床工具以改善眼底检查的重要一步眼科疾病的诊断和治疗。