Increasing the isoplanatic patch in adaptive optics ophthalmoscopy

增加自适应光学检眼镜中的等晕斑块

基本信息

批准号：
10403622
负责人：
Alfredo Dubra
金额：
$ 47.51万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-03-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY The optics of the eye suffer from imperfections (wavefront aberrations) that blur retinal images. This blur limits our ability to diagnose eye disease before irreversible damage and vision loss take place. Adaptive optics (AO) ophthalmoscopy can correct for this blur, which is unique to each eye and retinal location. Current AO ophthalmoscopes can only capture images of very small retinal areas because they cannot correct for the variation of the wavefront aberrations across the retina. This limitation impedes the use of this technology for detecting early signs of disease, which in turn, enable the early treatment that would mitigate irreversible vision loss. Here we propose to first measure how wavefront aberrations change across the retina in a human subject population to improve the design and operation of all future AO ophthalmoscopes. We also propose two novel methods for measuring and correcting wavefront aberrations that vary across the retina to increase the field of view of these instruments. First, we propose to measure aberrations sequentially at various points in the field of view and then deliver appropriate sequential wavefront corrections at each retinal location. This low-cost, low complexity approach could be used to double the retinal coverage of current AO scanning ophthalmoscopes. The second approach uses two wavefront correctors, the optimal axial positions of which will be determined by using the data on wavefront aberration changes with retinal location and wavelength across the population. This more complex approach aims to at least quadruple retinal coverage. The resulting increase in the field of view will be a major step towards translating AO ophthalmoscopy into a practical clinical tool for improving the diagnosis and treatment of eye diseases.

项目摘要眼睛的光学元件遭受模糊视网膜图像的瑕疵（波前畸变）。这个模糊的限制我们在不可逆转的损害和视力丧失之前诊断眼病的能力。自适应光学器件（AO）眼镜检查可以纠正这种模糊，这是每个眼睛和视网膜位置所特有的。当前AO 眼镜镜只能捕获非常小的视网膜区域的图像，因为它们无法纠正整个视网膜的波前畸变的变化。这种限制阻碍了该技术的使用检测疾病的早期迹象，从而使早期治疗能够减轻不可逆转的视力损失。在这里，我们建议首先衡量人类受试者的波前畸变如何在视网膜上发生变化人口改善所有未来AO眼镜的设计和运行。我们还提出了两本小说测量和纠正在视网膜各不相同的波前畸变以增加场地的方法这些乐器的视图。首先，我们提议在现场的各个点依次测量畸变在每个视网膜位置查看并提供适当的顺序波前校正。低成本，低成本复杂性方法可用于将当前AO扫描眼镜的视网膜覆盖范围加倍。第二种方法使用两个波前校正器，其最佳轴向位置将由使用有关波前像差的数据随着人群的视网膜位置和波长的变化。这更复杂的方法旨在至少四倍的视网膜覆盖范围。视野的结果增加将是将AO Ophthalmoscopicy转化为实用的临床工具的主要一步眼病的诊断和治疗。