2010 Carotenoids Gordon Research Conference

2010年类胡萝卜素戈登研究会议

• 批准号: 7798427
• 负责人: SUSAN T MAYNE
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7798427
• 关键词: Address; Affect; Age related macular degeneration; Aging; American; Anabolism; Area; Biological; Biological Models; Blindness; California; Canned Foods; Carotenoids; Child; Chronic Disease; Communities; Disease; Elderly; Engineering; Eye; Eye diseases; Food Supply; Genomics; Goals; Health; Human; Intake; International; Knowledge; Malignant Neoplasms; Metabolic; Metabolism; Methodology; Morbidity - disease rate; Participant; Photosynthesis; Play; Prevention; Provitamin A Carotenoid; Public Health; Regulation; Request for Proposals; Research; Research Personnel; Role; Science; Series; Systems Biology; Vitamin A Deficiency; abstracting; age related; disorder prevention; improved; meetings; mortality; multidisciplinary; oxidation; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): Abstract: This proposal requests partial support for an international meeting on Carotenoids as part of the Gordon Research Conference series to be held in Ventura, California January 17-22, 2010. The broad and long term goal of the conference is to increase our understanding of the science of carotenoids with the goal of applying the scientific knowledge to ultimately improve human health. The specific aims of this meeting will be to convene approximately 45 speakers who represent critical areas of carotenoid research from a multidisciplinary perspective with a total of 135 participants for a five day conference. The program will have nine sessions that broadly address current issues in carotenoid research, including the following: (i) genomics/modeling/systems biology; (ii) biosynthesis and regulation; (iii) photosynthesis; (iv) metabolic engineering of provitamin A carotenoids; (v) carotenoid transport and metabolism/apocarotenoids; (vi) biological actions of carotenoids; (vii) carotenoids in eye health; (viii) carotenoids and oxidation: chronic disease prevention; (ix) keynote, selected short talks. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference on Carotenoids (held every 3 years) is a foundational component of the series of conferences that propel research in the international community of carotenoid researchers. The health relatedness of this application is in clarifying how best to use carotenoid science to impact diseases known to be related to inadequate carotenoid intake (e.g., improving the provitamin A content of the food supply for the global prevention of vitamin A deficiency and resulting blindness) as well as to use new methodologies to elucidate the potential role of carotenoids in the prevention of chronic disease, especially age-related eye disease but also cancer and other diseases of aging. PUBLIC HEALTH RELEVANCE: Narrative: Carotenoids are critical for public health both domestically and internationally. Vitamin A deficiency is a leading cause of morbidity and mortality worldwide, especially affecting children (e.g., xeropthalmia). Staple foods can now be metabolically engineered to provide provitamin A carotenoids to improve the health of millions of the world's poorest children. Non-provitamin A carotenoids also appear to be important in human health; e.g., cutting edge research suggests certain carotenoids may play a role in the prevention of age- related macular degeneration, the leading cause of blindness in Americans over age 65.

描述（由申请人提供）：摘要：该提案要求对类胡萝卜素的国际会议进行部分支持，这是将于2010年1月17日至22日在加利福尼亚州文图拉举行的戈登研究会议系列的一部分。会议的广泛和长期目标是提高我们对类胡萝卜素科学的理解，目的是将科学知识应用于科学知识以最终改善人类健康。这次会议的具体目的是召集大约45名演讲者，他们从多学科的角度来代表类胡萝卜素研究的关键领域，共有135名参与者参加了为期五天的会议。该计划将有9次会议，可以广泛解决类胡萝卜素研究中的当前问题，包括以下内容：（i）基因组学/建模/系统生物学； （ii）生物合成和调节； （iii）光合作用； （iv）类胡萝卜素的代谢工程； （v）类胡萝卜素的运输和代谢/阿哌替苯基； （vi）类胡萝卜素的生物学作用； （vii）类胡萝卜素在眼睛健康中； （viii）类胡萝卜素和氧化：预防慢性疾病； （ix）主题演讲，精选的简短演讲。此外，两个晚上的海报会议将允许所有参与者为这些主题做出贡献。该应用的重要性是，戈登类胡萝卜素研究会议（每3年举行一次）是推动国际胡萝卜素研究人员研究的一系列会议的基本组成部分。该应用的健康相关性在于澄清如何最好地使用类胡萝卜素科学来影响已知的疾病与类胡萝卜素摄入相关的疾病（例如，改善食物供应的食物供应含量是全球预防维生素的缺乏症和盲目的盲目性），并使用新的方法尤其是eye疾病的疾病，但尤其是在疾病中疾病的疾病，但在eric疾病中的疾病中的疾病中的疾病却是carrotection of cartentive of Carrotencition the Carrotencorcentions the Carrotencor的癌症，这些疾病是指毛car的癌症，这些作用是指毛car的癌症。和其他衰老疾病。 公共卫生相关性：叙事：类胡萝卜素在国内和国际上对公共卫生至关重要。维生素A缺乏症是全球发病率和死亡率的主要原因，尤其是影响儿童（例如，静脉病原体）。现在，可以对主植物食品进行代谢设计，以提供类胡萝卜素，以改善世界上最贫穷的儿童的健康状况。非抗毒素A类胡萝卜素在人类健康中似乎也很重要。例如，尖端研究表明，某些类胡萝卜素可能在预防与年龄相关的黄斑变性中发挥作用，这是65岁以上美国人失明的主要原因。