Research Programs-Cancer Prevention

研究项目-癌症预防

• 批准号: 7513247
• 负责人: SUSAN T MAYNE
• 金额: $ 1.71万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-09 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513247
• 关键词: Area; Behavior Therapy; Biochemical; Cancer Control; Cancer Etiology; Cancer Information Service; Cancer Survivorship; Complement; Connecticut; Diet; Direct Costs; Early Diagnosis; Environmental Risk Factor; Epidemiologic Studies; Funding; Genetic; Genetic Polymorphism; Goals; Human; Interdisciplinary Study; Intervention; Investigation; Knowledge; Laboratories; Life Style; Link; Malignant Neoplasms; Methodology; Molecular; Molecular Epidemiology; Molecular Genetics; Newly Diagnosed; Obesity; Older Population; Patients; Peer Review; Phase; Physical activity; Population; Population Sciences; Prevention; Prevention Research; Primary Cancer Prevention; Primary Prevention; Publications; Race; Range; Recording of previous events; Registries; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; SEER Program; Schools; Science; Site; Techniques; Training Programs; Transdisciplinary Tobacco Research Center; United States; base; cancer epidemiology; cancer health disparity; cancer prevention; design; end of life care; member; multidisciplinary; neoplasm registry; nutrition; pre-doctoral; programs; survivorship; tobacco control; tumor

The Cancer Prevention and Control Research Program (CPC) of the YCC was initiated in the mid-1980s, with the selection of Yale as one of the first two NIH-funded Cancer Prevention Research Units (CPRUs) in the United States (US). In 1993, Dr. Susan Mayne was appointed as Program Leader, and in 1995, she was appointed as Associate Director for Population Science of the Center. Dr. Mayne oversees all aspects of prevention and control research for the YCC. CPC has a long and rich history of using the State of Connecticut as a population laboratory for cancer prevention and control research. The program is enhanced by its link to the Connecticut Tumor Registry, the oldest population-based tumor registry in the US and an NCI-funded SEER (Surveillance, Epidemiology, and End Results Program) site. In addition, researchers have access to the YCC Rapid Case Ascertainment Shared Resource (RCA), which identifies patients with newly diagnosed cancer throughout the State on a rapid basis, facilitating research projects. This Shared Resource is unique, and is complemented by the Molecular Epidemiology Shared Resource, allowing for population-based molecular epidemiology research. The program can thematically be grouped into two primary themes. The first theme is lifestyle factors and genetics in the etiology of cancer, with the objective of elucidating the roles of (a) nutrition, physical activity, and obesity in cancer; (b) environmental factors and cancer; and (c) molecular/genetic factors in cancer in human populations. The program also evaluates the causes of and approaches for mitigation of (d) racial disparities and cancer; and (e) develops new statistical methodologies to inform researchers in the areas above. The second major theme is behavioral interventions in cancer prevention/control. Research emphasizes the use of behavioral interventions to promote effective cancer prevention and control interventions, ranging from primary prevention (tobacco control, diet change) through early detection message framing, to survivorship interventions and finally to end-of-life care. The program has a total of 29 program members representing 4 schools and 9 departments. Program members have a total of $6.7 million in research grant funding (annual direct costs), of which $6.1 million direct costs is peer-reviewed. Of this, $1.8 million is NCI-funded. Program members contributed a total of 360 publications since the last renewal, of which 33% percentage are intra-programmatic and 8.3% percentage are interprogrammatic. Program members collaborate with other relevant groups at Yale including the Transdisciplinary Tobacco Use Research Center and the YCC Cancer Information Service, and the Program is the host for several training programs including an NCI-funded pre-doctoral training program in cancer epidemiology and genetics.

YCC癌症预防与控制研究计划（CPC）于20世纪80年代中期启动， 耶鲁大学被选为美国国立卫生研究院 (NIH) 资助的首批两个癌症预防研究单位 (CPRU) 之一 美国（US）。 1993 年，Susan Mayne 博士被任命为项目负责人，并于 1995 年被任命为项目负责人。 任命为中心人口科学副主任。梅恩博士负责监督各个方面 YCC的预防和控制研究。中国共产党利用国家的力量有着悠久而丰富的历史。 康涅狄格州作为癌症预防和控制研究的人口实验室。该计划得到加强 通过其与康涅狄格州肿瘤登记处的链接，康涅狄格州肿瘤登记处是美国最古老的基于人群的肿瘤登记处，也是一个 NCI 资助的 SEER（监测、流行病学和最终结果计划）网站。此外，研究人员 可以访问 YCC 快速病例确定共享资源 (RCA)，该资源可识别患有以下疾病的患者 全州范围内快速诊断出新的癌症，促进了研究项目。此共享 资源是独一无二的，并由分子流行病学共享资源进行补充，允许 基于人群的分子流行病学研究。该计划按主题可分为两类 主要主题。第一个主题是癌症病因中的生活方式因素和遗传学，目的是 阐明 (a) 营养、体力活动和肥胖在癌症中的作用； (b) 环境因素和 癌症; (c) 人群癌症的分子/遗传因素。该计划还评估了 (d) 种族差异和癌症的原因和缓解方法； (e) 制定新的统计 为上述领域的研究人员提供信息的方法。第二个主题是行为 癌症预防/控制的干预措施。研究强调使用行为干预 促进有效的癌症预防和控制干预措施，包括初级预防（烟草 控制、饮食改变）通过早期检测信息框架，到生存干预，最后到 临终关怀。该计划共有 29 名计划成员，分别代表 4 个学校和 9 个系。 计划成员总共拥有 670 万美元的研究资助资金（年度直接费用），其中 6.1 美元 百万直接成本经过同行评审。其中 180 万美元由 NCI 资助。计划成员贡献了 自上次更新以来共有 360 种出版物，其中 33% 为程序内出版物，8.3% 为程序内出版物 百分比是跨程序的。项目成员与耶鲁大学其他相关小组合作 包括跨学科烟草使用研究中心和 YCC 癌症信息服务，以及 该计划是多个培训项目的主办方，其中包括 NCI 资助的博士前培训项目 癌症流行病学和遗传学。