2010 Single-Molecule Approaches to Biology Gordon Research Conference

2010 年单分子生物学方法戈登研究会议

基本信息

批准号：
7904388
负责人：
William E Moerner
金额：
$ 0.7万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-15 至 2011-07-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal requests partial support for an international conference titled "Single-Molecule Approaches to Biology" as part of the Gordon Research Conference series to be held at Il Ciocco, Lucca (Barga), Italy, June 27 - July 2, 2010. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of the molecular machines central to biology. By observing individuals, it is possible to more deeply understand what they do, how they work individually, how they work together, and finally, how they work inside live cells. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules. The goals are to better promote the use of the single-molecule approach, to generate new biological knowledge, and to better inform the development and implementation of single- molecule techniques for compelling biological problems. The specific aims of this meeting are to convene 40 senior and emerging speakers who represent new thrusts of single-molecule research with a total of 170 participants for a five day conference in a relatively isolated setting. The program will cover cutting-edge developments in single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, super resolution imaging in cells, and novel probes for single-molecule imaging. In addition, four poster sessions will give participants various opportunities to actively participate in the scientific discourse. The significance of this application is that the Gordon Research Conference on Single-Molecule Approaches to Biology is a powerful vehicle to promote and enhance the exchange between emerging/innovative methods and important biological problems. The health-relatedness of this application derives from the fact that single-molecule approaches provide previously unobtainable data on fundamental biochemical and biophysical processes that are essential for all forms of life, including human pathogens, thus extending our knowledge and generating new approaches to improving human health. PUBLIC HEALTH RELEVANCE: The health-relatedness of this application derives from the fact that single- molecule approaches to biology provide previously unobtainable data on fundamental biochemical and biophysical processes that are essential for all forms of life, including human pathogens, thus extending our knowledge and generating new approaches to improving human health.

描述（由申请人提供）：该提案要求对国际会议的题为“单分子生物学方法”的国际会议，作为将在意大利IL Ciocco举行的Gordon研究会议系列的一部分，意大利卢卡（Barga），2010年6月27日至7月2日，2010年7月27日 - 2010年7月2日。生物学中心的分子机制。通过观察个人，有可能更深入地了解他们的工作，他们如何单独工作，如何共同工作，最后是它们如何在活细胞内部工作。这次会议旨在将分子和细胞生物学领域的顶级专家与创新者一起在单分子的测量和操纵中汇集在一起。目标是更好地促进单分子方法的使用，以产生新的生物学知识，并更好地告知单分子技术的开发和实施，以引起强迫生物学问题。这次会议的具体目的是召集40名高级和新兴演讲者，他们代表单分子研究的新作用，共有170名参与者参加了一个相对孤立的环境中的为期五天的会议。该程序将涵盖单分子测序，DNA/RNA/蛋白质相互作用，折叠机，细胞生物物理学，合成生物学和生物工程，力光谱，新方法开发，细胞中的超级分辨率成像以及单重大成像的新型探针。此外，四次海报会议将为参与者提供各种积极参与科学话语的机会。该应用的意义在于，关于生物学方法的戈登研究会议是促进和增强新兴/创新方法与重要生物学问题之间交流的强大工具。该应用程序的健康相关性来自以下事实：单分子方法提供了先前无法获得的关于基本生化和生物物理过程的数据，这些数据对所有形式的生活形式至关重要，包括人类病原体，从而扩展了我们的知识并为改善人类健康而产生新的方法。公共卫生相关性：该应用的与健康相关性来自以下事实：生物学的单分子方法提供了以前无法获得的有关基本生物化学和生物物理过程的数据，这些数据对于所有形式的生活，包括人类病原体，从而扩展了我们的知识并为改善人类健康而扩展我们的知识。