Chemistry of Preventing and Combating Disease

防病化学

• 批准号: 8006281
• 负责人: Daniel C Liebler
• 金额: $ 0.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006281
• 关键词: Address; American; Area; Award; Biological Markers; Biology; Boston; Characteristics; Chemicals; Chemistry; Disease; Environmental Exposure; Environmental Health; Event; Exposure to; Inflammation; Inflammatory; Intervention; Link; Mission; Molecular; National Institute of Environmental Health Sciences; Nitrogen; Oxygen; Paper; Pathway interactions; Post-Translational Protein Processing; Postdoctoral Fellow; Prevention; Process; Proteins; Request for Applications; Research; Research Personnel; Role; Scientist; Signal Pathway; Signal Transduction; Societies; Stress; Students; Toxic effect; Toxicology; Translating; Work; adduct; biological adaptation to stress; combat; environmental agent; inflammatory marker; meetings; prevent; programs; public health relevance; structural biology; symposium

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 240th National Meeting and Exposition in Boston, MA from Sunday, 22-Aug-2010 to Wednesday, 25-Aug-2010. A unique feature of this ACS meeting is the broad theme of the entire meeting--"Chemistry of Preventing and Combating Disease," which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, drugs and endogenous chemicals. The division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. The global theme "Chemistry of Preventing and Combating Disease" aligns closely with the core focus areas of the Division of Chemical Toxicology and thus provides a thematic backdrop that reinforces programming in the Division and provides related content particularly for students and postdoctoral fellows. Four interrelated sessions are planned around the central theme "Chemistry of Preventing and Combating Disease" and include invited talks by a diverse group of leading established and up-and-coming scientists presenting their recent research results. The two sessions for which support is requested have especially strong relevance to the mission of the NIEHS. The first (Symposium #1) is entitled "Protein adducts and stress response pathways" and addresses molecular mechanisms by which electrophiles and reactive oxygen and nitrogen species trigger stress and adaptive signaling pathways by selective modification of protein targets. The second (Symposium #4) is entitled "Inflammation markers and interventions" and addresses the chemistry of reactive species involved in inflammation, the formation of characteristic molecular species that may serve as biomarkers for inflammatory processes and the role of inflammation as an integrating mechanism for disease processes associated with environmental exposures. Proffered paper sessions and a Young Investigators Symposium offer opportunities for young investigators to present their primary contributions. Other highlights are a keynote awards symposium and scientific perspectives address. PUBLIC HEALTH RELEVANCE: Effective prevention and treatment of environmentally-related diseases requires an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will examine the chemical mechanisms by which molecular damage translates to disease. Specifically, the sponsored symposia will examine new work on how inflammation and molecular damage processes create signals that trigger environmentally-induced disease processes.

描述（由申请人提供）：本申请要求在2010年8月22日至8月25日星期日至2010年8月25日（星期日）在马萨诸塞州波士顿举行的第240届全国性会议上，在美国化学学会化学毒理学（ACS）的化学毒理学部门提供支持。这次ACS会议的一个独特特征是整个会议的广泛主题：“预防和打击疾病的化学反应”，它与所有ACS部门的编程中的突出事件保持一致。 ACS化学毒理学分区的使命是促进对有助于疾病过程和环境剂，药物和内源性化学物质的毒性的化学机制的理解。该部门整合了化学，化学生物学，结构生物学，毒理学，环境健康科学和疾病机制的工作。全球主题“预防和打击疾病的化学反应”与化学毒理学分工的核心重点区域紧密相符，因此提供了主题背景，可以加强该部门的编程，并为学生和博士后研究员提供相关内容。计划了四个相互关联的会议，围绕中心主题“预防和打击疾病的化学”，其中包括一群领先的成立和新兴的科学家的邀请演讲，介绍了他们最近的研究结果。请求支持的两个会议与NIEHS的使命特别有意义。第一个（研讨会＃1）的标题为“蛋白质加合物和应力响应途径”，并解决了分子机制，通过这些机制，通过选择性修饰蛋白质靶标，电力和活性氧和活性氧和氮物种触发应力和适应性信号传导途径。第二个（专题讨论会＃4）的标题为“炎症标记和干预措施”，并解决了涉及炎症的反应性物种的化学，特征分子物种的形成可能是炎症过程的生物标志物，以及炎症作为与环境暴露相关的疾病过程的综合机制的作用。提供的纸质会议和年轻的调查人员研讨会为年轻调查人员提供了他们的主要贡献的机会。其他亮点是主题奖研讨会和科学观点的讲话。 公共卫生相关性：有效的预防和治疗环境相关疾病需要了解将环境暴露与疾病机制联系起来的基本机制。 美国化学学会化学毒理学的这一会议将检查分子损害转化为疾病的化学机制。 具体而言，赞助的研讨会将研究有关炎症和分子损伤过程如何产生触发环境引起的疾病过程的信号的新工作。