Application of Multimodal Imaging Techniques to Examine Language Recovery in Post

应用多模态成像技术检查术后语言恢复

• 批准号: 8089918
• 负责人: Swathi Kiran
• 金额: $ 12.51万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089918
• 关键词: Accounting; Address; Aftercare; Aphasia; Applications Grants; Area; Brain; Brain region; Chronic; Contralateral; Data; Data Analyses; Development; Diagnosis; Effectiveness; Electroencephalography; Etiology; Functional Magnetic Resonance Imaging; Future; Goals; Healthcare; Healthy People 2010; Imaging Techniques; Individual; Infarction; K-18 conjugate; Knowledge; Language; Language Disorders; Language Therapy; Learning; Left; Lesion; Link; Location; Maps; Mentors; Methods; Modeling; Multimodal Imaging; Names; Noise; Outcomes Research; Patients; Pattern; Performance; Phase; Population; Psycholinguistics; Recommendation; Recovery; Rehabilitation therapy; Research; Residual state; Seeds; Signal Transduction; Specific qualifier value; Stroke; Structure; Survivors; Techniques; Tissues; Training; Work; aphasia rehabilitation; base; career development; chronic stroke; clinically significant; design; experience; health disparity; improved; language processing; neuroimaging; neuromechanism; post stroke; programs; research study; semantic processing; tool

DESCRIPTION (provided by applicant): One goal of the Healthy People 2010 program is to reduce health disparities across different segments of the population. Diagnosis and treatment of language deficits in patients with chronic aphasia is one area where disparities continue to exist even though this topic is of great theoretical and clinical significance. The current research on this topic, however, lacks specific recommendations on what language therapies have the potential to facilitate maximal language recovery in individuals with stroke and more importantly, the neural mechanisms that underlie such plasticity changes. This grant proposal extends the PI's previous work in monolingual aphasia rehabilitation to utilizing advanced functional neuroimaging techniques to better understand the mechanisms involved in language recovery in patients who receive theoretically motivated language therapy. The aim of this K18 mentored grant proposal is for the candidate to learn (a) detailed structural lesion analysis techniques, (b) state of the art fMRI data analysis techniques specific to stroke populations, and (c) MEG/EEG experimentation and analysis methods to examine effective connectivity changes subsequent to rehabilitation. These techniques will be implemented in a small scale project involving ten patients with aphasia who will participate in a ten week structured naming therapy program and will undergo pre and post therapy structural T1, functional MRI, and MEG/EEG experiments. At the end of this project, the candidate will be successful at utilizing an integrated set of tools that will ultimately allow a detailed, anatomically grounded characterization of the psycholinguistic, structural and functional basis of language recovery in chronic stroke survivors. The proposed work is also clinically important because it has the potential to define future health care practice in chronic stroke management. PUBLIC HEALTH RELEVANCE: This training plan will integrate three complementary advanced neuroimaging techniques to examine the effect of language therapy on language recovery in individuals with post stroke aphasia who have naming deficits. The proposed work is important because it has the potential to define future health care practice in chronic stroke management. Better therapies will be developed if we understand how the brain is capable of recovering subsequent to a stroke and conversely, we will be able to characterize brain plasticity mechanism more reliably if we are confident about the effectiveness of therapies that can improve language recovery in individuals with chronic aphasia.

描述（由申请人提供）：“2010 年健康人民”计划的目标之一是减少不同人群之间的健康差异。慢性失语症患者语言缺陷的诊断和治疗是一个仍然存在分歧的领域，尽管这一主题具有重要的理论和临床意义。然而，目前关于这一主题的研究缺乏关于哪些语言疗法有可能促进中风患者最大语言恢复的具体建议，更重要的是，这种可塑性变化背后的神经机制缺乏具体建议。 这项拨款提案将 PI 之前在单语失语症康复方面的工作扩展到利用先进的功能性神经影像技术来更好地了解接受理论驱动的语言治疗的患者的语言恢复机制。这项 K18 指导资助提案的目的是让候选人学习 (a) 详细的结构性病变分析技术，(b) 针对中风人群的最先进的功能磁共振成像数据分析技术，以及 (c) MEG/EEG 实验和分析方法检查康复后有效的连接变化。这些技术将在一个小规模项目中实施，该项目涉及 10 名失语症患者，他们将参加为期 10 周的结构化命名治疗计划，并接受治疗前后的结构 T1、功能 MRI 和 MEG/EEG 实验。 在该项目结束时，候选人将成功地利用一套集成的工具，最终对慢性中风幸存者语言恢复的心理语言学、结构和功能基础进行详细的、基于解剖学的表征。拟议的工作在临床上也很重要，因为它有可能定义慢性中风管理的未来医疗保健实践。 公共健康相关性：该培训计划将整合三种互补的先进神经影像技术，以检查语言治疗对有命名缺陷的中风后失语症患者语言恢复的影响。拟议的工作很重要，因为它有可能定义慢性中风管理的未来医疗保健实践。如果我们了解大脑如何能够在中风后恢复，就会开发出更好的疗法；相反，如果我们对改善中​​风患者语言恢复的疗法的有效性充满信心，我们将能够更可靠地描述大脑可塑性机制。慢性失语症。