A Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy

关于石油和天然气开发、生育力和怀孕的孕前队列研究

基本信息

批准号：
10705071
负责人：
Mary D Willis
金额：
$ 41.25万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705071
关键词：
Address Affect Air American Aromatic Polycyclic Hydrocarbons Award Back Benzene Birth Boston Canada Chemicals Child Child Development Child Health Cohort Studies Communities Complex Conceptions Contracts Couples Data Data Analyses Data Collection Data Science Development Diet Disease Enrollment Environmental Epidemiology Environmental Hazards Environmental Pollutants Epidemiology Exposure to Faculty Fellowship Female Fertility Flare Formaldehyde Funding Gases Geography Gestational Diabetes Grant HRK gene Health Human Hypertension Industry Institution Interdisciplinary Study Internet Late pregnancy Life Style Light Live Birth Low Birth Weight Infant Measurement Measures Medical History Menstrual cycle Mentors Metabolic Diseases Methods National Institute of Child Health and Human Development National Institute of Environmental Health Sciences Noise Oils Outcome Participant Particulate Matter Pharmaceutical Preparations Play Policies Pollution Positioning Attribute Postdoctoral Fellow Postpartum Women Pre-Eclampsia Pregnancy Pregnancy loss Premature Birth Probability Production Prospective cohort Prospective, cohort study Province Public Health Public Health Schools Questionnaires Recording of previous events Reporting Reproductive Health Research Research Design Research Personnel Resources Risk Role Spontaneous abortion Surveys TNFSF15 gene Techniques Time Toluene Toxicology Training United States United States National Institutes of Health Universities Water Woman Work Workplace career cohort community intervention cost effective data integration design early pregnancy early pregnancy loss epidemiology study follow-up improved novel participant enrollment pollutant population health postpartum health pre-doctoral pregnancy hypertension professor prospective recruit reproductive risk perception social stressor sociodemographics time-to-pregnancy toxicant trying to conceive volatile organic compound

项目摘要

PROJECT SUMMARY Over 17.6 million North Americans live within 1.6km of an oil and gas development (OGD) facility. Recent studies indicate that OGD results in the release of reproductive toxicants (e.g., particulate matter, volatile organic compounds [VOCs], polycyclic aromatic hydrocarbons [PAHs]) at levels that may harm human health, including fertility, early pregnancy loss, pregnancy-related disorders, and birth outcomes. Epidemiologic studies on OGD to date have largely focused on live birth outcomes, have not included personal exposure measurements, and have little data on key confounders. Building upon data analysis from an NIEHS-funded predoctoral fellowship (F31-ES029801) and training in prospective cohort designs in her postdoctoral research, Dr. Mary Willis’ Early Independence Award application launches the first prospective cohort study on OGD-related pollution and reproductive health. This proposal leverages ongoing recruitment from the Pregnancy Study Online (PRESTO, R01-HD086742), an internet-based preconception cohort study of North American couples trying to conceive (n>16,000 female participants), to examine the influence of OGD-related exposures on reproductive health. This cohort has remarkable geographic diversity, spanning all 50 U.S. states and all 10 Canadian provinces. To date, >4,500 of the women reside in communities with OGD activity and this application will use geo-targeted methods to enroll an additional 1,000 women. Aim 1 develops OGD-related exposure metrics in the PRESTO cohort, an extension of Dr. Willis’ previous work. Exposure assessment methods include 1a) complex spatial data integration of industry-related information that spans back to participants’ own births, 1b) a supplemental questionnaire of perceived risks about OGD, and 1c) personal exposures to air, water, and noise in a subset of 150 women at three time points in the preconception to early pregnancy periods. All exposure assessment methods are validated, state-of-the-art approaches. Aim 2 applies these exposure metrics in a longitudinal framework to examine the influence of OGD on important reproductive health outcomes in the full PRESTO cohort. Outcomes include 2a) fertility (fecundability, the per-cycle probability of pregnancy), 2b) pregnancy loss (spontaneous abortion), 2c) pregnancy-related hypertensive and metabolic disorders (gestational hypertension, pre-eclampsia, gestational diabetes), and 2d) birth outcomes (preterm birth, low birth weight.) The aims set the stage for a “Research to Action” proposal that explores the efficacy of personal or community interventions for specific OGD exposures, as well as the groundwork for an R01 proposal with follow-up for maternal postpartum health and child development. By leveraging an established internet-based prospective cohort study, this proposal addresses the logistical challenges of efficiently assessing the influence of health effects of emerging environmental hazards. The results of this project have high potential to improve public health by demonstrating a novel policy-relevant framework to investigate emerging environmental hazards. This award will allow Dr. Willis to launch her career at the intersection of environmental epidemiology, data science, and reproductive health.

项目概要超过 1760 万北美人居住在石油和天然气开发 (OGD) 设施 1.6 公里范围内。表明 OGD 会导致生殖毒物的释放（例如颗粒物、挥发性有机物）化合物 [VOC]、多环芳烃 [PAH]）的含量可能危害人类健康，包括 OGD 的生育力、早期流产、妊娠相关疾病和出生结果的流行病学研究。迄今为止，主要关注活产结果，尚未包括个人暴露测量，并且基于 NIEHS 资助的博士前奖学金的数据分析，关于关键混杂因素的数据很少。（F31-ES029801）以及她博士后研究中前瞻性队列设计的培训，玛丽·威利斯博士的早期研究独立奖申请启动了第一个关于 OGD 相关污染的前瞻性队列研究该提案利用了怀孕研究在线（PRESTO， R01-HD086742），一项针对试图怀孕的北美夫妇的基于互联网的孕前队列研究（n>16,000 名女性参与者），检查 OGD 相关暴露对生殖健康的影响。迄今为止，该群体具有显着的地理多样性，涵盖美国所有 50 个州和加拿大所有 10 个省。 > 4,500 名女性居住在有 OGD 活动的社区，该应用程序将使用地理定位方法目标 1 在 PRESTO 队列中再招募 1,000 名女性，制定与 OGD 相关的暴露指标。 Willis 博士之前工作的扩展包括 1a) 复杂的空间数据。整合可追溯到参与者自己出生的行业相关信息，1b) 补充关于 OGD 的感知风险调查问卷，以及 1c) 个人接触空气、水和噪音的子集对 150 名女性在孕前至妊娠早期的三个时间点进行了所有暴露评估。目标 2 纵向应用这些暴露指标。框架来检查 OGD 对完整 PRESTO 中重要生殖健康结果的影响结果包括 2a) 生育能力（生育能力、每个周期怀孕的概率），2b) 妊娠失败。（自然流产），2c）与妊娠相关的高血压和代谢性疾病（妊娠期高血压，先兆子痫、妊娠糖尿病）和 2d）出生结果（早产、低出生体重）。目标设定 “从研究到行动”提案的阶段，探讨个人或社区干预措施的有效性具体的 OGD 暴露，以及 R01 提案的基础以及产后后续行动通过利用一项已建立的基于互联网的前瞻性队列研究，该提案解决了有效评估新兴疾病对健康影响的后勤挑战该项目的结果通过证明具有改善公众健康的巨大潜力。威利斯博士将获得一个新的政策相关框架来调查新出现的环境危害。在环境流行病学、数据科学和生殖健康的交叉领域开启她的职业生涯。